Unrestricted somatic stem cells: Interaction with CD34+ cells in vitro and in vivo, expression of homing genes and exclusion of tumorigenic potential

Cytotherapy

Volumn 13, Issue 3, 2011, Pages 357-365

  Jeltsch, Kathrin Sonja ^a   Radke, Teja Falk ^b   Laufs, Stephanie ^a   Giordano, Frank Anton ^a   Allgayer, Heike ^a,c   Wenz, Frederik ^d   Zeller, Walter Jens ^a   Kögler, Gesine ^b   Fruehauf, Stefan ^e   Maier, Patrick ^a,d  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b University Medical Center Duesseldorf   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e Paracelsus Klinik   (Germany)

Author keywords

CD34; co transplantation; engraftment; tumorigenicity; unrestricted somatic stem cells

Indexed keywords

CD34 ANTIBODY; CD44V ANTIGEN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; L SELECTIN; RAC1 PROTEIN; RAC2 PROTEIN;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CARCINOGENICITY; CELL CONTACT; CELL INTERACTION; CLINICAL STUDY; COCULTURE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SCID MOUSE; SOMATIC CELL; UMBILICAL CORD BLOOD;

EID: 79951694131     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.3109/14653249.2010.523076     Document Type: Article

References (37)

1. Urbano-Ispizua A. Risk assessment in haematopoietic stem cell transplantation: stem cell source. Best Pract Res Clin Haematol. 2007;20:265-80. (Pubitemid 46585968)
2. Bensidhoum M, Chapel A, Francois S, Demarquay C, Mazurier C, Fouillard L, et al. Homing of in vitro expanded Stro-1-or Stro-1+ human mesenchymal stem cells into the NOD/SCID mouse and their role in supporting human CD34 cell engraftment. Blood. 2004;103:3313-9. (Pubitemid 38525658)
3. Noort WA, Kruisselbrink AB, in 't Anker PS, Kruger M, van Bezooijen RL, de Paus RA, et al. Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice. Exp Hematol. 2002;30: 870-8. (Pubitemid 34838889)
4. Koc ON, Gerson SL, Cooper BW, Dyhouse SM, Haynesworth SE, Caplan AI, et al. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol. 2000;18:307-16. (Pubitemid 30056419)
5. Lazarus HM, Haynesworth SE, Gerson SL, Rosenthal NS, Caplan AI. Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use. Bone Marrow Transplant. 1995;16:557-64.
6. Majumdar MK, Thiede MA, Mosca JD, Moorman M, Gerson SL. Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells. J Cell Physiol. 1998;176:57-66. (Pubitemid 28277195)
7. De Becker A, Van Hummelen P, Bakkus M, Vande Broek I, De Wever J, De Waele M, et al. Migration of culture-expanded human mesenchymal stem cells through bone marrow endothelium is regulated by matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-3. Haematologica. 2007; 92:440-9. (Pubitemid 350144289)
8. Karp JM, Leng Teo GS. Mesenchymal stem cell homing: the devil is in the details. Cell Stem Cell. 2009;4:206-16.
9. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for Defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315-7. (Pubitemid 44269669)
10. Friedenstein AJ, Chailakhyan RK, Latsinik NV, Panasyuk AF, Keiliss-Borok IV. Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation. 1974;17: 331-40.
11. Caplan AI. Mesenchymal stem cells. J Orthop Res. 1991;9: 641-50.
12. Haynesworth SE, Goshima J, Goldberg VM, Caplan AI. Characterization of cells with osteogenic potential from human marrow. Bone. 1992;13:81-8.
13. Pittenger MF, Mackay AM, Beck SC, Jaiswa lRK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143-7. (Pubitemid 29282067)
14. Kö g ler G, Sensken S, Airey JA, Trapp T, Muschen M, Feldhahn N, et al. A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med. 2004;200:123-35. (Pubitemid 38982172)
15. Kö g ler G, Radke TF, Lefort A, Sensken S, Fischer J, Sorg RV, et al. Cytokine production and hematopoiesis supporting activity of cord blood-derived unrestricted somatic stem cells. Exp Hematol. 2005;33:573-83. (Pubitemid 40592174)
16. Chan SL, Choi M, Wnendt S, Kraus M, Teng E, Leong HF, et al. Enhanced in vivo homing of uncultured and selectively amplified cord blood CD34+ cells by cotransplantation with cord blood-derived unrestricted somatic stem cells. Stem Cells. 2007;25:529-36. (Pubitemid 46232809)
17. Buss EC, Schiedlmeier B, Ho AD, Zeller WJ, Fruehauf S. The FBMD-1 stroma cell line secretes a unique moiety which can increase retroviral transduction of lineage-committed and primitive human peripheral blood progenitor cells. Cancer Gene Ther. 2001;8:440-9. (Pubitemid 32757961)
18. Dillmann F, Veldwijk MR, Laufs S, Sperandio M, Calandra G, Wenz F, et al. Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to Imatinib and Nilotinib. Leuk Lymphoma. 2009;50:1676-86.
19. Lee RH, Pulin AA, Seo MJ, Kota DJ, Ylostalo J, Larson BL, et al. Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the antiinfl ammatory protein TSG-6. Cell Stem Cell. 2009;5:54-63.
20. Ghodsizad A, Niehaus M, Kogler G, Martin U, Wernet P, Bara C, et al. Transplanted human cord blood-derived unrestricted somatic stem cells improve left-ventricular function and prevent left-ventricular dilation and scar formation after acute myocardial infarction. Heart. 2009;95:27-35.
21. Kollet O, Petit I, Kahn J, Samira S, Dar A, Peled A, et al. Human CD34(+)CXCR4(-) sorted cells harbor intracellular CXCR4, which can be functionally expressed and provide NOD/SCID repopulation. Blood. 2002;100:2778-86.
22. Schiedlmeier B, Kuhlcke K, Eckert HG, Baum C, Zeller WJ, Fruehauf S. Quantitative assessment of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined immunodeficient mice. Blood. 2000;95:1237-48. (Pubitemid 30099832)
23. Maier P, Fleckenstein K, Li L, Laufs S, Zeller WJ, Baum C, et al. Overexpression of MDR1 using a retroviral vector differentially regulates genes involved in detoxification and apoptosis and confers radioprotection. Radiat Res. 2006;166:463-73. (Pubitemid 44353429)
24. van der Horst EH, Leupold JH, Schubbert R, Ullrich A, Allgayer H. TaqMan-based quantification of invasive cells in the chick embryo metastasis assay. Biotechniques. 2004;37: 940-2, 4, 6.
25. Liedtke S, B.A., Bosch J, Bosse F, Kruse F, Zhao X, Santourlidis S, Kögler G. The HOX Code as a "biological fi ngerprint" to distinguish functionally distinct stem cell populations derived from cord blood. Stem Cell Res 2010;5: 40-50.
26. Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of infl ammation: the leukocyte adhesion cascade updated. Nat Rev Immunol. 2007;7:678-89. (Pubitemid 47327397)
27. Lapidot T, Kollet O. The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/ SCID and NOD/SCID/B2m(null) mice. Leukemia. 2002;16: 1992-2003. (Pubitemid 35203441)
28. Kollet O, Spiegel A, Peled A, Petit I, Byk T, Hershkoviz R, et al. Rapid and effi cient homing of human CD34(+)CD38(-/ low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice. Blood. 2001;97:3283-91.
29. Avigdor A, Goichberg P, Shivtiel S, Dar A, Peled A, Samira S, et al. CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow. Blood. 2004;103:2981-9. (Pubitemid 38451670)
30. Gazitt Y. Recent developments in the regulation of peripheral blood stem cell mobilization and engraftment by cytokines, chemokines, and adhesion molecules. J Hematother Stem Cell Res. 2001;10:229-36. (Pubitemid 32423548)
31. Gu Y, Filippi MD, Cancelas JA, Siefring JE, Williams EP, Jasti AC, et al. Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases. Science. 2003;302: 445-9. (Pubitemid 37296270)
32. Park SK, Won JH, Kim HJ, Bae SB, Kim CK, Lee KT, et al. Co-transplantation of human mesenchymal stem cells promotes human CD34+ cells engraftment in a dose-dependent fashion in NOD/SCID mice. J Korean Med Sci. 2007;22: 412-9.
33. Kluth SM, Buchheiser A, Houben AP, Geyh S, Krenz T, Radke TF, et al. DLK-1 as a marker to distinguish unrestricted somatic stem cells and mesenchymal stromal cells in cord blood. Stem Cells Dev. 2010;19:1471-83.
34. Moore KA, Pytowski B, Witte L, Hicklin D, Lemischka IR. Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs. Proc Natl Acad Sci USA. 1997;94:4011-6. (Pubitemid 27180490)
35. Kö g ler G, Sensken S, Wernet P. Comparative generation and characterization of pluripotent unrestricted somatic stem cells with mesenchymal stem cells from human cord blood. Exp Hematol. 2006;34:1589-95. (Pubitemid 44548121)
36. Battiwalla M, Hematti P. Mesenchymal stem cells in hematopoietic stem cell transplantation. Cytotherapy. 2009;11: 503-15.
37. Newman RE, Yoo D, LeRoux MA, Danilkovitch-Miagkova A. Treatment of infl ammatory diseases with mesenchymal stem cells. Inflamm Allergy Drug Targets. 2009;8:110-23.