Regulatory T-cells in Graves' orbitopathy: Baseline findings and immunomodulation by anti-T lymphocyte globulin

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 2, 2011, Pages 422-429

  Kahaly, George J ^a   Shimony, Orly ^b   Gellman, Yechiel N ^b   Lytton, Simon D ^d   Eshkar Sebban, Lora ^b   Rosenblum, Nir ^b   Refaeli, Efrat ^b   Kassem, Sameer ^c   Ilany, Jacob ^e   Naor, David ^b  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^d SeraDiaLogistics   (Germany)

^e SHEBA MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI T LYMPHOCYTE GLOBULIN; CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 7 RECEPTOR; RADIOACTIVE IODINE; T LYMPHOCYTE ANTIBODY; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOCRINE OPHTHALMOPATHY; FEMALE; GRAVES DISEASE; HUMAN; HUMAN CELL; IMMUNOMODULATION; LEUKOCYTE; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; THYROID SURGERY;

ADULT; AGED; ANIMALS; ANTILYMPHOCYTE SERUM; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GLOBULINS; GRAVES DISEASE; GRAVES OPHTHALMOPATHY; HUMANS; IMMUNOMODULATION; INDICATORS AND REAGENTS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LEUKOCYTE COUNT; LYMPHOCYTE CULTURE TEST, MIXED; MALE; MIDDLE AGED; MONOCYTES; PROGNOSIS; RABBITS; RECEPTORS, INTERLEUKIN-7; T-LYMPHOCYTES, REGULATORY; YOUNG ADULT;

ORYCTOLAGUS CUNICULUS;

EID: 79951693448     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-1424     Document Type: Article

References (29)

1. Brusko TM, Putnam AL, Bluestone JA 2008 Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunol Rev 223:371-390 (Pubitemid 351986182)
2. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St. Groth B, Clayberger C, Soper DM, Ziegler SF, Bluestone JA 2006 CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 203:1701-1711 (Pubitemid 44036276)
3. Pan D, Shin YH, Gopalakrishnan G, Hennessey J, De Groot LJ 2009 Regulatory T cells in Graves' disease. Clin Endocrinol (Oxf) 71:587-593
4. Wang H, Zhao S, Tang X, Li J, Zou P 2006 Changes of regulatory T cells in Graves' disease. J Huazhong Univ Sci Technolog Med Sci 26:545-547
5. Saitoh O, Abiru N, Nakahara M, Nagayama Y 2007 CD8+CD122+T cells, a newly identified regulatory T subset, negatively regulate Graves' hyperthyroidism in a murine model. Endocrinology 148:6040-6046 (Pubitemid 350146196)
6. McLachlan SM, Nagayama Y, Pichurin PN, Mizutori Y, Chen CR, Misharin A, Aliesky HA, Rapoport B 2007 The link between Graves' Disease and Hashimoto's thyroiditis: a role for regulatory T cells. Endocrinology 148:5724-5733 (Pubitemid 350146191)
7. Hiromatsu Y, Kaku H, Miyake I, Murayama S, Soejima E 2002 Role of cytokines in the pathogenesis of thyroid-associated ophthalmopathy. Thyroid 12:217-221 (Pubitemid 34259802)
8. Lazarus JH, Marino M 2010 Orbit-thyroid relationship. In: Wiersinga WM, Kahaly GJ, eds. Graves' orbitopathy: a multidisciplinary approach, questions and answers. 2nd revised edition. Bale, Switzerland: Karger Publishers; 26-32
9. Naujokat C, Berges C, Fuchs D, Sadeghi M, Opelz G, Daniel V 2007 Antithymocyte globulins suppress dendritic cell function by multiple mechanisms. Transplantation 83:485-497
10. + regulatory T cells. J Am Soc Nephrol 17:2844-2853
11. +. Blood 111:3675-3683
12. Bartalena L, Baldeschi L, Dickinson A, Eckstein A, Kendall-Taylor P, Marcocci C, Mourits M, Perros P, Boboridis K, Boschi A, Currò N, Daumerie C, Kahaly GJ, Krassas GE, Lane CM, Lazarus JH, Marinò M, Nardi M, Neoh C, Orgiazzi J, Pearce S, Pinchera A, Pitz S, Salvi M, Sivelli P, Stahl M, von Arx G, Wiersinga WM 2008 Consensus statement of the European Group on Graves' Orbitopathy (EUGOGO) on management of GO. Eur J Endocrinol 158:273-285
13. Bartalena L, Baldeschi L, Dickinson AJ, Eckstein A, Kendall-Taylor P, Marcocci C, Mourits MP, Perros P, Boboridis K, Boschi A, Currò N, Daumerie C, Kahaly GJ, Krassas G, Lane CM, Lazarus JH, Marinò M, Nardi M, Neoh C, Orgiazzi J, Pearce S, Pinchera A, Pitz S, Salvi M, Sivelli P, Stahl M, von Arx G, Wiersinga WM 2008 Consensus statement of the European Group on Graves' Orbitopathy (EUGOGO) on management of Graves' orbitopathy. Thyroid 18:333-346 (Pubitemid 351415802)
14. Xia N, Zhou S, Liang Y, Xiao C, Shen H, Pan H, Deng H, Wang N, Li QQ 2006 CD4+ T cells and the Th1/Th2 imbalance are implicated in the pathogenesis of Graves' ophthalmopathy. Int J Mol Med 17:911-916
15. Matsushita M, Hayshi T, Ando S, Sekigawa I, Iida N, Hashimoto H, Hirose S 2000 Changes of CD4/CD8 ratio and interleukin-16 in systemic lupus erythematosus. Clin Rheumatol 19:270-274 (Pubitemid 30612556)
16. Laurence J 1993 T-cell subsets in health, infectious disease and idiopathic CD4+ T-lymphocytopenia. Ann Intern Med 119:55-62 (Pubitemid 23177299)
17. Sakaguchi S, Yamaguchi T, Nomura T, Ono M 2008 Regulatory T cells and immune tolerance. Cell 133:775-787 (Pubitemid 351707693)
18. Mohty M 2007 Mechanism of action of antithymocyte globulin: T cell depletion and beyond. Leukemia 21:1387-1394
19. Marazuela M, García-López MA, Figueroa-Vega N, de la Fuente H, Alvarado-Sánchez B, Monsiváis-Urenda A, Sánchez-Madrid F, González-Amaro R 2006 Regulatory T cells in human autoimmune thyroid disease. J Clin Endocrinol Metab 91:3639-3646
20. Kaaba SA, Al-Harbi SA 1995 Abnormal lymphocyte subsets in Kuwaiti patients with type-1 insulin-dependent diabetes mellitus and their first-degree relatives. Immunol Lett 47:209-213
21. Saudek F, Havdrova T, Boucek P, Karasova L, Novota P, Skibova J 2004 Polyclonal anti-T cell therapy for type I diabetes mellitus of recent onset. Rev Diabet Stud 1:80-88
22. Kumar S, Bahn RS 2003 Relative overexpression of macrophage-derived cytokines in orbital adipose tissue from patients with Graves' ophthalmopathy. J Clin Endocrinol Metab 88:4246-4250 (Pubitemid 37153727)
23. Wakelkamp IM, Bakker O, Baldeschi L, Wiersinga WM, Prummel MF 2003 TSH-R expression and cytokine profile in orbital tissue of active vs. inactive Graves' ophthalmopathy patients. Clin Endocrinol (Oxf) 58:280-287
24. + T regulatory cell-mediated suppression. Immunity 30:636-645
25. Chen X, Oppenheim JJ 2010 TNF-α: an activator of CD4+FoxP3+ TNFR2+ regulatory T cells. Curr Dir Autoimmun 11:119-134
26. Zhou L, Chong MM, Littman DR 2009 Plasticity of CD4+ T cell lineage differentiation. Immunity 30:646-655
27. Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay M, Solomon M, Selby W, Alexander SI, Nanan R, Kelleher A, Fazekas de St. Groth B 2006 Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J Exp Med 203:1693-1700 (Pubitemid 44036275)
28. Polansky JK, Kretschmer K, Freyer J, Floess S, Garbe A, Baron U, Olek S, Hamann A, von Boehmer H, Huehn J 2008 DNA methylation controls Foxp3 gene expression. Eur J Immunol 38:1654-1663
29. Lytton SD, Denton CP, Nutzenberger AM 2007 Treatment of autoimmune disease with rabbit anti-T lymphocyte globulin (rATG): clinical efficacy and potential mechanisms of action. Ann NY Acad Sci 1110:285-296 (Pubitemid 350043017)