Regulatory T cells in Graves' disease

Clinical Endocrinology

Volumn 71, Issue 4, 2009, Pages 587-593

  Pan, Deshun ^a,b   Shin, Young Ha ^b   Gopalakrishnan, Geetha ^b   Hennessey, James ^c   De Groot, Leslie J ^a,b,c,d  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b BROWN UNIVERSITY   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d BethIsrael Hospital ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 7 RECEPTOR; IODINE 131; MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3;

ADULT; ARTICLE; AUTOIMMUNITY; BLOOD SAMPLING; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; EUTHYROIDISM; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GRAVES DISEASE; HUMAN; HYPERTHYROIDISM; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RADIOISOTOPE THERAPY; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION;

CD4-POSITIVE T-LYMPHOCYTES; GRAVES DISEASE; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; IODINE RADIOISOTOPES; POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY;

EID: 69949153350     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2009.03544.x     Document Type: Article

References (29)

1. Weetman, A.P. (2003) Autoimmune thyroid disease: propagation and progression. European Journal of Endocrinology, 148, 1 9.
2. Douglas, R.S., Gianoukakis, A.G., Kamat, S. et al. (2007) Aberrant expression of the insulin-like growth factor-1 receptor by T cells from patients with Graves' disease may carry functional consequences for disease pathogenesis. Journal of Immunology, 178, 3281 3287.
3. Yanagawa, T., Mangklabruks, A., Chang, Y.B. et al. (1993) Human histocompatibility leukocyte antigen-DQA1*0501 allele associated with genetic susceptibility to Graves' disease in a Caucasian population. Journal of Clinical Endocrinology and Metabolism, 76, 1569 1574.
4. Yanagawa, T., Hidaka, Y., Guimaraes, V. et al. (1995) CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population. Journal of Clinical Endocrinology and Metabolism, 80, 41 45.
5. Ueda, H., Howson, J.M., Esposito, L. et al. (2003) Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature, 423, 506 511.
6. Dechairo, B.M., Zabaneh, D., Collins, J. et al. (2005) Association of the TSHR gene with Graves' disease: the first disease specific locus. European Journal of Human Genetics, 13, 1223 1230.
7. Jacobson, E.M. Tomer, Y. (2007) The CD40, CTLA-4, thyroglobulin, TSH receptor, and PTPN22 gene quintet and its contribution to thyroid autoimmunity: back to the future. Journal of Autoimmunity, 28, 85 98.
8. Allahabadia, A., Heward, J.M., Mijovic, C. et al. (1998) Lack of association between polymorphism of the thyrotropin receptor gene and Graves' disease in United Kingdom and Hong Kong Chinese patients: case control and family-based studies. Thyroid, 8, 777 780.
9. Sakaguchi, S., Ono, M., Setoguchi, R. et al. (2006) Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunological Reviews, 212, 8 27.
10. Seddiki, N., Santner-Nanan, B., Martinson, J. et al. (2006) Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. Journal of Experimental Medicine, 203, 1693 1700.
11. Liu, W., Putnam, A.L., Xu-Yu, Z. et al. (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. Journal of Experimental Medicine, 203, 1701 1711.
12. Banham, A.H., Powrie, F.M. Suri-Payer, E. (2006) FOXP3+ regulatory T cells: current controversies and future perspectives. European Journal of Immunology, 36, 2832 2836.
13. Raimondi, G., Turner, M.S., Thomson, A.W. et al. (2007) Naturally occurring regulatory T cells: recent insights in health and disease. Critical Reviews in Immunology, 27, 61 95.
14. Beissert, S., Schwarz, A. Schwarz, T. (2006) Regulatory T cells. Journal of Investigative Dermatology, 126, 15 24.
15. Pyzik, M. Piccirillo, C.A. (2007) TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets. Journal of Leukocyte Biology, 82, 335 346.
16. Miyara, M. Sakaguchi, S. (2007) Natural regulatory T cells: mechanisms of suppression. Trends in Molecular Medicine, 13, 108 116.
17. Pinkse, G.G., Tysma, O.H., Bergen, C.A. et al. (2005) Autoreactive CD8 T cells associated with beta cell destruction in type 1diabetes. Proceedings of the National Academy of Sciences of the United States of America, 102, 18425 18430.
18. Sancho, D., Gomez, M. Sanchez-Madrid, F. (2005) CD69 is an immunoregulatory molecule induced following activation. Trends in Immunology, 26, 136 140.
19. Livak, K.J. Schmittgen, T.D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the (-Delta DeltaC(T)) method. Methods, 25, 402 408.
20. Karandikar, N.J., Vanderlugt, C.L., Walunas, T.L. et al. (1996) CTLA-4: a negative regulator of autoimmune disease. Journal of Experimental Medicine, 184, 783 788.
21. Lahl, K., Loddenkemper, C., Drouin, C. et al. (2007) Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. Journal of Experimental Medicine, 204, 57 63.
22. Nakano, A., Watanabe, M., Iida, T. et al. (2007) Apoptosis-induced decrease of intrathyroidal CD4(+)CD25(+) regulatory T cells in autoimmune thyroid diseases. Thyroid, 17 : 25 31. PMID: 17274744.
23. Marazuela, M., Garcia-Lopez, M.A., Figueroa-Vega, N. et al. (2006) Regulatory T cells in human autoimmune thyroid disease. Journal of Clinical Endocrinology and Metabolism, 91, 3639 3646. Epub 2006 Jun 27.
24. Guimaraes, V.C., Quintans, J., Fisfalen, M.E. et al. (1996) Immunosuppression of thyroiditis. Endocrinology, 137, 2199 2207.
25. Gangi, E., Vasu, C., Cheatem, D. et al. (2005) IL-10-producing CD4+CD25+ regulatory T cells play a critical role in granulocyte-macrophage colony-stimulating factor-induced suppression of experimental autoimmune thyroiditis. Journal of Immunology, 174, 7006 7013.
26. Molteni, M., Rossetti, C., Scrofani, S. et al. (2003) Regulatory CD8+ T cells control thyrotropin receptor-specific CD4+ clones in healthy subjects. Cancer Detection and Prevention, 27, 167 174.
27. Watanabe, M., Yamamoto, N., Maruoka, H. et al. (2002) Independent involvement of CD8+ CD25+ cells and thyroid autoantibodies in disease severity of Hashimoto's disease. Thyroid, 12, 801 808.
28. Alvarado-Sanchez, B., Hernandez-Castro, B., Portales-Perez, D. et al. (2006) Regulatory T cells in patients with systemic lupus erythematosus. Journal of Autoimmunity, 27, 110 118.
29. Korn, T., Reddy, J., Gao, W. et al. (2007) Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nature Medicine, 13, 423 431.