Evidence that RF-Amide Related Peptide-3 is not a Mediator of the Inhibitory Effects of Psychosocial Stress on Gonadotrophin Secretion in Ovariectomised Ewes

Journal of Neuroendocrinology

Volumn 23, Issue 3, 2011, Pages 208-215

  Papargiris, M M ^a   Rivalland, E T A ^a   Clarke, I J ^a   Smith, J T ^a   Pereira, A ^a   Tilbrook, A J ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Ewes; GnIH; GnRH; LH; RFRP 3; Stress

Indexed keywords

GONADOTROPIN; HYDROCORTISONE; LUTEINIZING HORMONE; MESSENGER RNA; PROTEIN FOS; RF AMIDE RELATED PEPTIDE 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN REGION; CONTROLLED STUDY; EWE; FEMALE; HORMONE RELEASE; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MENTAL STRESS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; FEMALE; GONADOTROPINS; HYDROCORTISONE; HYPOTHALAMUS; LUTEINIZING HORMONE; NEUROPEPTIDES; OVARIECTOMY; RANDOM ALLOCATION; RESTRAINT, PHYSICAL; RNA, MESSENGER; SECRETORY PATHWAY; SHEEP; STRESS, PSYCHOLOGICAL;

EID: 79951690695     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2010.02094.x     Document Type: Article

References (37)

1. Clarke IJ, Pompolo S. Synthesis and secretion of GnRH. Anim Reprod Sci 2005; 88: 29-55.
2. Tsutsui K, Saigoh E, Ukena K, Teranishi H, Fujisawa Y, Kikuchi M, Ishii S, Sharp PJ. A novel avian hypothalamic peptide inhibiting gonadotropin release. Biochem Biophys Res Commun 2000; 275: 661-667.
3. Kriegsfeld LJ, Feng Mei D, Bentley GE, Ubuka T, Manson AO, Inoue K, Ukena K, Tsutsui K, Silver R. Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals. PNAS 2006; 103: 2410-2415.
4. Smith JT, Coolen LM, Kriegsfeld LJ, Sari IP, Jaafarzadehshirazi MR, Maltby M, Bateman K, Goodman RL, Tilbrook AJ, Ubuka T, Bentley GE, Clarke IJ, Lehman MN. Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium for seasonal breeding in the sheep. Endocrinology 2008; 149: 5770-5782.
5. Kirby ED, Geraghty AC, Ubuka T, Bentley GE, Kaufer D. Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats. PNAS 2009; 106: 11324-11329.
6. Tachibana T, Sato M, Takahashi H, Ukena K, Tsutsui K, Furuse M. Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks. Brain Res 2005; 1050: 94-100.
7. Tilbrook AJ, Turner AI, Clarke IJ. Stress and reproduction: central mechanisms and sex differences in non-rodent species. Stress 2002; 5: 83-100.
8. Breen KM, Karsch FJ. New insights regarding glucocorticoids, stress and gonadotropin suppression. Front Neuroendocrinol 2006; 27: 233-245.
9. Oakley AE, Breen KM, Clarke IJ, Karsch FJ, Wagenmaker ER, Tilbrook AJ. Cortisol reduces gonadotropin-releasing hormone pulse frequency in follicular phase ewes: influence of ovarian steroids. Endocrinology 2009; 150: 341-349.
10. Karsch FJ, Breen KM. Glucocorticoids: do they really contribute to stress-related reproductive inhibition? Expert Rev Endocrinol Metab 2009; 4: 295-298.
11. Papargiris MM, Tilbrook AJ. Effect of RF-amide-related peptide-3 on luteinizing hormone and follicle-stimulating hormone synthesis and secretion in ovine pituitary gonadotropes. Asia Pac J Endocrinol 2010; 150: 5549-5556.
12. Smith JT, Clarke IJ. Gonadotropin inhibitory hormone function in mammals. Trends Endocrinol Metab 2010; 21: 255-260.
13. Tilbrook AJ, Canny BJ, Serapiglia MD, Ambrose TJ, Clarke IJ. Suppression of the secretion of luteinizing hormone due to isolation/restraint stress in gonadectomised rams and ewes is influenced by sex steroids. J Endocrinol 1999; 160: 469-481.
14. Walsh JP, Rao A, Simmons DM, Clarke IJ. Proopiomelanocortin mrna levels in ovine hypothalamus are not reduced at the time of the preovulatory luteinising hormone surge. J Neuroendocrinol 1998; 10: 803-808.
15. Rivalland ETA, Tilbrook AJ, Turner AI, Iqbal J, Pompolo S, Clarke IJ. Projections to the preoptic area from the paraventricular nucleus, arcuate nucleus and the bed nucleus of the stria terminalis are unlikely to be involved in stress-induced suppression of GnRH secretion in sheep. Neuroendocrinology 2006; 84: 1-13.
16. Iqbal J, Pompolo S, Sakurai T, Clarke IJ. Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus. J Neuroendocrinol 2001; 13: 1033-1041.
17. Bocking AD, McMillen IC, Harding R, Thorburn GD. Effect of reduced uterine blood flow on fetal and maternal cortisol. J Dev Physiol 1986; 8: 237-245.
18. Lee VWK, Cumming IA, de Kretser DM, Findlay JK, Hudson B, Keogh EJ. Regulation of gonadotrophin secretion in rams from birth to sexual maturity. J Reprod Fertil 1976; 46: 1-6.
19. Qi Y, Oldfield BJ, Clarke IJ. Projections of RFamide-related peptide-3 neurones in the ovine hypothalamus, with special reference to regions regulating energy balance and reproduction. J Neuroendocrinol 2009; 21: 690-697.
20. Stackpole CA, Turner AI, Clarke IJ, Lambert GW, Tilbrook AJ. Seasonal differences in the effect of isolation and restraint stress on the luteinizing hormone response to gonadotropin-releasing hormone in hypothalamopituitary disconnected, gonadectomized rams and ewes. Biol Reprod 2003; 69: 1158-1164.
21. Breen KM, Davis TL, Doro LC, Nett TM, Oakley AE, Padmanabhan V, Rispoli LA, Wagenmaker ER, Karsch FJ. Insight into the neuroendocrine site and cellular mechanism by which cortisol suppresses pituitary responsiveness to gonadotropin-releasing hormone. Endocrinology 2008; 149: 767-773.
22. Breen KM, Karsch FJ. Does cortisol inhibit pulsatile luteinizing hormone secretion at the hypothalamic or pituitary level? Endocrinology 2004; 145: 692-698.
23. Breen KM, Oakley AE, Pytiak AV, Tilbrook AJ, Wagenmaker ER, Karsch FJ. Does cortisol acting via the type II glucocorticoid receptor mediate suppression of pulsatile luteinizing hormone secretion in response to psychosocial stress? Endocrinology 2007; 148: 1882-1890.
24. Clarke IJ, Sari IP, Qi Y, Smith JT, Parkington HC, Ubuka T, Iqbal J, Li Q, Tilbrook A, Morgan K, Pawson AJ, Tsutsui K, Millar RP, Bentley GE. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology 2008; 149: 5811-5821.
25. Sari IP, Rao A, Smith JT, Tilbrook AJ, Clarke IJ. Effect of RF-amide-related peptide-3 on luteinizing hormone and follicle-stimulating hormone synthesis and secretion in ovine pituitary gonadotropes. Endocrinology 2009; 150: 5549-5556.
26. Handa RJ, Burgess LH, Kerr JE, O'Keefe JA. Gonadal steroid hormone receptors and sex differences in the hypothalamo-pituitary-adrenal axis. Horm Behav 1994; 28: 464-476.
27. Turner AI, Rivalland ETA, Clarke IJ, Tilbrook AJ. Stressor specificity of sex differences in hypothalamo-pituitary adrenal axis activity: cortisol responses to exercise, endotoxin, wetting and isolation/restraint stress in gonadectomized male and female sheep. Endocrinology 2010; 151: 4324-4331.
28. Turner AI, Canny BJ, Hobbs RJ, Bond JD, Clarke IJ, Tilbrook AJ. Influence of sex and gonadal status of sheep on cortisol secretion in response to ACTH and on cortisol and LH secretion in response to stress: importance of different stressors. J Endocrinol 2002; 173: 113-122.
29. Critchlow V, Liebelt RA, Bar-Sela M, Mountacstle W, Lipscomb HS. Sex difference in resting pituitary-adrenal function in the rat. Am J Physiol 1963; 205: 807-815.
30. Kitay JI. Pituitary adrenal function in the rat after gonadectomy and gonadal hormone replacement. Endocrinology 1963; 73: 253-260.
31. Mitsushima D, Masuda J, Kimura K. Sex differences in the stress induced release of acetylcholine in the hippocampus and corticosterone from the adrenal cortex in rats. Neuroendocrinology 2003; 78: 234-240.
32. Tilbrook AJ, Clarke IJ. Neuroendocrine mechanisms of innate states of attenuated responsiveness of the hypothalamo-pituitary adrenal axis to stress. Front Neuroendocrinol 2006; 27: 285-307.
33. Canny BJ, O'Farrell KA, Clarke IJ, Tilbrook AJ. The influence of sex and gonadectomy on the hypothalamo-pituitary-adrenal axis of the sheep. J Endocrinol 1999; 162: 215-225.
34. Sapolsky RM, Romero LM, Munck AU. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions Endocr Rev 2000; 21: 55-89.
35. Kilgour R. The contributions of psychology to a knowledge of farm animal behaviour. Appl Anim Behav 1976; 2: 197-205.
36. Pierce BN, Hemsworth PH, Rivalland ETA, Wagenmaker ER, Morrissey AD, Papargiris MM, Clarke IJ, Karsch FJ, Turner AI, Tilbrook AJ. Psychosocial stress suppresses attractivity, proceptivity and pulsatile LH secretion in the ewe. Horm Behav 2008; 54: 424-434.
37. Kyrou L, Tsigos C. Stress mechanisms and metabolic complications. Horm Metab Res 2007; 39: 430-438.