Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 27, 2009, Pages 11324-11329

  Kirby, Elizabeth D ^a   Geraghty, Anna C ^a   Ubuka, Takayoshi ^a   Bentley, George E ^a   Kaufer, Daniela ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

GnIH; Reproduction; RFRP

Indexed keywords

GLUCOCORTICOID RECEPTOR; GONADORELIN; GONADOTROPIN INHIBITORY HORMONE; HORMONE INHIBITOR; LUTEINIZING HORMONE; NEUROPEPTIDE; UNCLASSIFIED DRUG;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENITAL SYSTEM; HORMONAL REGULATION; HORMONE INHIBITION; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; HYPOTHALAMUS NUCLEUS; IMMOBILIZATION STRESS; IMMUNOHISTOCHEMISTRY; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MALE INFERTILITY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; REPRODUCTION; UPREGULATION;

ADRENALECTOMY; ANIMALS; HYPOTHALAMIC HORMONES; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; HYPOTHALAMUS; LUTEINIZING HORMONE; MALE; MODELS, BIOLOGICAL; NEUROPEPTIDES; PITUITARY-ADRENAL SYSTEM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; STRESS, PHYSIOLOGICAL;

PHASIANIDAE; PRIMATES; RATTUS; RODENTIA;

EID: 67650445488     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0901176106     Document Type: Article

References (52)

1. Rivier C, Rivest S (1991) Effect of stress on the activity of the hypothalamic-pituitary-gondal axis: Peripheral and central mechanisms. Biol Reprod 45:523-532.
2. Rivier C, Rivier J, Vale W (1986) Stress-induced inhibition of reproductive functions: Role of endogenous corticotropin-releasing factor. Science 231:607-609.
3. Du Ruisseau P, Tache Y, Brazeau P, Collu R (1979) Effects of chronic immobilization stress on pituitary hormone secretion, on hypothalamic factor levels, and on pituitary responsiveness to LHRH and TRH in female rats. Neuroendocrinology 29:90-99.
4. Gonzalez-Quijano MI, Ariznavarreta C, Martin AI, Treguerres JAF, Lopez-Calderon A (1991) Naltrexone does not reverse the inhibitory effect of chronic restraint on gonadotropin secretion in the intact male rat. Neuroendocrinology 54:447-453.
5. Sato Y, et al. (1996) Effects of long-term psychological stress on sexual behavior and brain catecholamine levels. J Androl 17:83-90.
6. Retana-Marquez S, Bonilla-Jaime H, Vazquez-Palacios G, Matrinez-Garcia R, Velazquez-Moctezuma J (2003) Changes in masculine sexual behavior, corticosterone and testosterone in response to acute and chronic stress in male rats. Horm Behav 44:327-337.
7. Dubey AK, Plant TM (1985) A suppression of gonadotropin secretion by cortisol in castrated male rhesus monkeys (Macaca mulatta) mediated by the interruption of hypothalamic gonadotropin-releasing hormone release. Biol Reprod 33:423-431.
8. Lerman SA, et al. (1997) Effects of corticosterone on reproduction in male Sprague-Dawley rats. Reprod Toxicol 11:799-805.
9. Kalantaridou SN, Makrigiannakis A, Zoumakis E, Chrousos GP (2004) Reproductive functions of corticotropin-releasing hormone. Research and potential clinical utility of antalarmins (CRH receptor type 1 antagonists). Am J Reprod Immunol 51:269-274.
10. Li XF, et al. (2006) Differential role of corticotropin-releasing factor receptor types 1 and 2 in stress-induced suppression of pulsatile luteinizing hormone secretion in female rat. J Neuroendocrinol 18:602-610.
11. Tsutsui K, et al. (2000) A novel avian hypothalamic peptide inhibiting gonadotropin release. Biochem Biophys Res Commun 275:661-667.
12. Kriegsfeld LJ, et al. (2006) Identification and characterization of a gonadotropininhibitory system in the brains of mammals. Proc Natl Acad Sci USA 103:2410-2415.
13. Johnson MA, Tsutsui K, Fraley GS (2007) Rat RFamide-related peptide-3 stimulates GH secretion, inhibits LH secretion, and has variable effects on sex behavior in the adult male rat. Horm Behav 51:171-180.
14. Yin H, Ukena K, Ubuka T, Tsutsui K (2005) A novel G protein-coupled receptor for gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica): Identification, expression and binding activity. J Endocrinol 184:257-266.
15. Hinuma S, et al. (2000) New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals. Nat Cell Biol 2:703-708.
16. Bentley GE, et al. (2008) Gonadotropin-inhibitory hormone and its receptor in the avian reproductive system. Gen Comp Endocrinol 156:34-43.
17. Murakami M, et al. (2008) Hypophysiotropic role of RFamide-related peptide-3 (RFRP-3) in the inhibition of LH secretion in female rats. J Endocrinol 199:105-112.
18. Bentley GE, et al. (2006) Rapid inhibition of female sexual behavior by gonadotropininhibitory hormone (GnIH). Horm Behav 49:550-555.
19. Osugi T, et al. (2004) Gonadotropin-inhibitory hormone in Gambel's white-crowned sparrow (Zonotrichia leucophrys gambelii): cDNA identification, transcript localization and functional effects in laboratory and field experiments. J Endocrinol 182:33-42.
20. Calisi RM, Rizzo NO, Bentley GE (2008) Seasonal differences in hypothalamic EGR-1 and GnIH expression following capture-handling stress in house sparrows (Passer domesticus). Gen Comp Endocrinol 157:283-287.
21. Ubuka T, Ukena K, Sharp PJ, Bentley GE, Tsutsui K (2006) Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail. Endocrinology 147:1187-1194.
22. Rizwan MZ, Porteous R, Herbison AE, Anderson GM (2009) Cells expressing RFRP-1/3, the mammalian GnIH orthologs, are not hypophysiotropic neuroendocrine neurons in the rat. Endocrinology 150:1413-1420.
23. Wu M, Dumalska I, Morozova E, van den Pol AN, Alreja M (2009) Gonadotropin inhibitory hormone (GnIH) innervates, inhibits basal forebrain vGluT2-GnRH neurons via a direct postsynaptic mechanism. J Physiol 587:1401-1411.
24. Ducret E, Anderson GM, Herbison AE (2009) RFamide-related peptide-3 (RFRP-3), a mammalian gonadotropin-inhibitory ortholog, regulates gonadotropin-releasing hormone (GnRH) neuron firing in the mouse. Endocrinology 150:2799-2804.
25. Anderson GM, Relf HL, Rizwan MZ, Evans JJ (2009) Central and peripheral effects of RFamide-related peptide-3 on LH and prolactin secretion in rats. Endocrinology 150:1834-1840.
26. Suarez M, Fiol de Cuneo M, Vincenti L, Ruiz RD (1996) Changes in corticosterone levels and sperm functional activity by chronic stress in rats. Arch Physiol Biochem 104:351-356.
27. Retana-Márquez S, Bonilla-Jaime H, Vázquez-Palacios G, Martínez-García R (2009) Naltrexone effects on male sexual behavior, corticosterone, and testosterone in stressed male rats. Physiol Behav 96:333-342.
28. Li XF, et al. (2004) Differential effects of repeated restraint stress on pulsatile lutenizing hormone secretion in female fischer, lewis and wistar rats. J Neuroendocrinol 16:620-627.
29. Sheiner EK, Sheiner E, Carel R, Potashnik G, Shoham-Vardi I (2002) Potential association between male infertility and occupational psychological stress. J Occup Environ Med 44:1093-1099.
30. Eskiocak S, et al. (2005) Glutathione and free sulphydryl content of seminal plasma in healthy medical students during and after exam stress. Hum Reprod 20:2595-2600.
31. Cyr NE, Romero LM (2007) Chronic stress in free-living European starlings reduces corticosterone concentrations and reproductive success. GenCompEndocrinol 151:82-89.
32. Vulliemoz NR, Xiao E, Xia-Zhang L, Rivier J, Ferin M (2008) Astressin B, a nonselective corticotropin-releasing hormone receptor antagonist, prevents the inhibitory effect of ghrelin on luteinizing hormone pulse frequency in the ovariectomized rhesus monkey. Endocrinology 149:869-874.
33. Berga SL (2008) Stress and reproduction: A tale of false dichotomy. Endocrinology 149:867-868.
34. Hafez B, Hafez ESE (2004) Stress/aging: Endocrine profiles/reproductive dysfunction in men. Arch Androl 50:207-238.
35. Tilbrook AJ, Turner AI, Clarke IJ (2000) Effects of stress on reproduction in non-rodent mammals: The role of glucocorticoids and sex differences. Rev Reproduction 5:105-113.
36. Wingfield JC, Sapolsky RM (2003) Reproduction and resistance to stress: When and how. J Neuroendocrinol 15:711-724.
37. Sakakura M, Takebe K, Nakagawa S (1975) Inhibition of luteinizing hormone secretion induced by synthetic LRH by long-term treatment with glucocorticoids in human subjects. J Clin Endocrinol Metab 40:774-779.
38. Attardi B, et al. (1997) Glucocorticoid repression of gonadotropin-releasing hormone gene expression and secretion in morphologically distinct subpopulations of GT1-7 cells. Mol Cell Endocrinol 131:241-255.
39. Suter DE, SchwartzNB(1985) Effects of glucocorticoidsonresponsiveness of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone by male rat pituitary cells in vitro. Endocrinology 117:849-854.
40. Gambacciani M, Yen SSC, Rasmussen DD (1986) GnRH release from the mediobasal hypothalamus: In vitro inhibition by corticotropin-releasing factor. Neuroendocrinology 43:533-536.
41. Ubuka T, et al. (2008) Gonadotropin-inhibitory hormones neurons interact directly with gonadotropin-releasing hormone-I and -II neurons in european starling brain. Endocrinology 149:268-278.
42. Bentley GE, et al. (2006) Interactions of gonadotropin-releasing hormone (GnRH) and gonadotropin-inhibtory hormone (GnIH) in birds and mammals. J Exp Zool 305A:807-814.
43. Gibson EM, et al. (2008) Alterations in RFamide-related peptide expression are coordinated with the preovulatory luteinizing hormone surge. Endocrinology 149:4958-4969.
44. Clarke IJ, et al. (2008) Potent action of RFRP-3 on pituitary gonadotropes indicative of an hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology 149:5811-5821.
45. Rizwan MZ, Porteous R, Herbison AE, Anderson GM (2009) Cells expressing RFamide-related peptide-1/3, the mammalian gonadotropin-inhibitory hormone orthologs, are not hypophysiotropic neuroendocrine neurons in the rat. Endocrinology 150:1413-1420.
46. Mor I, et al. (2001) Modified testicular expression of stress-associated "readthrough" acetylcholinesterase predicts male infertility. FASEB J 15:2039-2041.
47. Kaufer D, Friedman A, Seidman S, Soreq H (1999) Acute stress facilitates long-lasting changes in cholinergic gene expression. Nature 393:373-377.
48. Bentley GE, et al. (2009) GnIH: A multifunctional neuropeptide. J Neuroendocrinol
49. Ferin M (1999) Clinical review 105: Stress and the reproductive cycle. J Clin Endocrinol Metab 84:1768-1774.
50. Champagne DM (2006) Should fertilization treatment start with reducing stress? Hum Reprod 21:1651-1658.
51. Einarsson S, Brandt Y, Rodriguez-Martinez H, Madej A (2008) Conference lecture: Influence of stress on estrus, gametes and early embryo development in the sow. Theriogenology 70:1197-1201.
52. Zhao S, Fernald RD (2005) Comprehensive algorithm for quantitative real-time polymerase chain reaction. J Comput Biol 12:1045-1062.