Improved T cell assay for identification of type 1 diabetes patients

Journal of Immunological Methods

Volumn 344, Issue 1, 2009, Pages 79-83

  Brooks Worrell, Barbara ^a   Warsen, Adelaide ^a   Palmer, Jerry P ^a  

^a VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

Author keywords

Immune monitoring; Islet proteins; T cell assay; T cells; Type 1 diabetes

Indexed keywords

ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INSULIN DEPENDENT DIABETES MELLITUS; INTERMETHOD COMPARISON; MOLECULAR WEIGHT; PANCREAS ISLET CELL; PRIORITY JOURNAL; SERODIAGNOSIS; T LYMPHOCYTE;

DIABETES MELLITUS, TYPE 1; HUMANS; IMMUNOBLOTTING; ISLETS OF LANGERHANS; MONITORING, IMMUNOLOGIC; SENSITIVITY AND SPECIFICITY; T-LYMPHOCYTES;

EID: 65049083839     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jim.2009.03.004     Document Type: Article

References (28)

1. Abou-Zeid C., Filley E., Steele J., and Rook B.A.W. A simple new method for using antigens separated by polyacrylamide gel electrophoresis to stimulate lymphocytes in vitro after converting the bands cut from western blots into antigen-bearing particles. Journal of Immunological Methods 98 (1987) 5
2. Bendelac A., Carnaud C., Boitard C., and Bach J.F. Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells. Journal of Experimental Medicine 166 (1987) 823
3. Brooks-Worrell B.M., and Splitter G.A. Antigens of Brucella abortus S19 immunodominant for bovine lymphocytes as identify by one and two-dimensional cellular immunoblotting. Infection and Immunity 60 (1992) 2459
4. Brooks-Worrell B.M., Starkebaum G.A., Greenbaum C., and Palmer J.P. Peripheral blood mononuclear cells of insulin-dependent diabetic patients respond to multiple islet cell proteins. Journal of Immunology 157 (1996) 5668
5. Brooks-Worrell B.M., Juneja R., Minokadeh A., Greenbaum C.J., and Palmer J.P. Cellular immune response to human islet proteins in antibody-positive type 2 diabetic patients. Diabetes 48 (1999) 983
6. Brooks-Worrell B., Gersuk V.H., Greenbaum C., and Palmer J.P. Intermolecular antigen spreading occurs during the pre-clinical period of human type 1 diabetes. Journal of Immunology 166 (2001) 5265
7. Brooks-Worrell B.M., Greenbaum C.J., Phillips C.E., Palmer J.P., and Pihoker C. Autoimmunity to islet proteins in children diagnosed with new onset diabetes. Journal of Clinical Endocrinology and Metabolism 89 (2004) 2222
8. Freeman M., and Weetman A.P. T and B cell reactivity to adrenal antigens in autoimmune Addison's disease. Clinical and Experimental Immunology 88 (1992) 275
9. Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14 (1965) 619
10. Goel A., Chiu H., Felton J., Palmer J.P., and Brooks-Worrell B. T cell responses to islet antigens improve detection of autoimmune diabetes and identifies patients with more severe β-cell lesions in phenotypic type 2 diabetes. Diabetes 56 (2007) 2110
11. Herold K.C., Type 1 Diabetes Trialnet Study Group, and The Trialnet Study Group. Mechanistic assay committee report of the Trialnet T cell validation study in type 1 diabetes. Diabetes 56 S1 (2007) A319
12. Juneja R., Hirsch I.B., Naik R.G., Brooks-Worrell B.M., Greenbaum C.J., and Palmer J.P. Islet cell antibodies and glutamic acid decarboxylase antibodies but not the clinical phenotype help to identify type 1 1/2 diabetes in patients presenting with type 2 diabetes. Metabolism 50 (2001) 1008
13. Lampeter E.F., Homberg M., Quabeck K., Schaefer U.W., Wernet P., Bertrams J., Grosse-Wilde H., Gries F.A., and Kolb H. Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation. Lancet 341 (1993) 1243
14. Lee S.P., Stoker N.G., Grant K.A., Handzel V.T., Hussain R., McAdam K.P.W.J., and Dockrell H.M. Cellular immune responses of leprosy contacts to fractionated Mycobacerterium leprae antigens. Infection and Immunity 57 (1989) 2475
15. Lernmark A. Islet cell antibodies. Diabetic Medicine 4 (1987) 285
16. Lohmann T., Seissler J., Verlohren H.-J., Schroder S., Rotger J., Dahn K., Mortgenthaler N., and Scherbaum W.A. Distinct genetic and immunological features in patients with onset of IDDM before and after age 40. Diabetes Care 20 (1997) 524
17. McCance D.R., Hanson R.L., Pettitt D.F., Bennett P.H., Hadden D.R., and Knowler W.C. Diagnosing diabetes mellitus: do we need new criteria?. Diabetologia 40 (1997) 247
18. Melby P.C., and Sacks D.L. Identification of antigens recognized by T cells in human Leishmaniasis: analysis of T cell clones by immunoblotting. Infection and Immunity 57 (1989) 2971
19. Miller B.J., Appel M.C., O'Neil J.J., and Wicker L.S. Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. Journal of Immunology 140 (1988) 52
20. Palmer J.P., Asplin C.M., Clemons P., Lyen K., Tatpati O., Raghu P.K., and Paquette T.L. Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 222 (1983) 1337
21. Pham B.N., Prin L., Gosset D., Hatron P.Y., Devulder B., Capron A., and Dessaint J.P. T lymphocyte activation in systemic lupus erythematosus analysed by proliferative response to nucleoplasmic proteins on nitrocellulose immunoblot. Clinical and Experimental Immunology 77 (1989) 168
22. Rahier J., Goebbels R.M., and Henquin J.C. Cellular composition of the human diabetic pancreas. Diabetologia 24 (1983) 366
23. Seyfert-Margolis V., Gisler T.D., Asare A.L., Wang R.S., Dosch H.M., Brooks-Worrell B., Eisenbarth G.S., Palmer J.P., Greenbaum C.J., Gitelman S.E., Nepom G.T., Bluestone J.A., and Herold K.C. Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study. Diabetes 55 (2006) 2588
24. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20 (1997) 1183
25. Tuomi T., Groop L.C., Zimmet P.Z., Rowley M.J., Knowles W., and Mackay I.R. Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of diabetes. Diabetes 42 (1993) 359
26. VanNoort J.M., Van Sechel A., Boon J., Boersma W.J.A., Pooman C.H., and Lucas C.J. Minor myelin proteins can be major targets for peripheral blood T cells from both multiple sclerosis patients and healthy subjects. Journal of Neuroimmunology 46 (1993) 67
27. Wang J., Miao D., Babu S., Yu J., Barker J., Klingensmith G., Rewers M., Eisenbarth G.S., and Yu L. Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesity. Journal of Clinical Endocrinology and Metabolism 92 (2007) 88
28. Young D.B., and Lamb J.R. T lymphocytes respond to solid-phase antigen: a novel approach to the molecular analysis of cellular immunity. Immunology 59 (1986) 167