Peripheral Blood Mononuclear Cells of Insulin-Dependent Diabetic Patients Respond to Multiple Islet Cell Proteins

Journal of Immunology

Volumn 157, Issue 12, 1996, Pages 5668-5674

  Brooks Worrell, Barbara M ^a,b   Starkebaum, Gordon A ^a   Greenbaum, Carla ^a   Palmer, Jerry P ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; PROTEIN;

ARTICLE; CELL CULTURE; HUMAN; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE ACTIVATION; PANCREAS ISLET; T LYMPHOCYTE;

AUTOANTIGENS; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; HUMANS; ISLETS OF LANGERHANS; LYMPHOCYTE ACTIVATION; PROTEINS; T-LYMPHOCYTES;

EID: 0030589224     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Feldmann, M., C. Dayan, B. Rapoport, and M. Londei. 1992. T cell activation and antigen presentation in human thyroid autoimmunity. J. Autoimmun. 5:115.
2. VanNoort, J. M., A. Van Sechel, J. Boon, W. J. A. Boersma, C. H. Polman, and C. J. Lucas. 1993. Minor myelin proteins can be major targets for peripheral blood T cells from both multiple sclerosis patients and healthy subjects. J. Neuroimmunol. 46:67.
3. Kojima, K., T. Berger, H. Lassmann, D. Hinze-Selch, Y. Zhang, J. Gehrmann, K. Reske, H. Wekerle, and C. Linington. 1994. Experimental autoimmune panencephalitis and uveoretinitis transferred to the Lewis rat by T lymphocytes specific for the S1000β molecule, a calcium binding protein of Astroglia. J. Exp. Med. 180:817.
4. Hohlfeld, R., M. Londei, L. Massacesi, and M. Salvetti. 1995. T-cell autoimmunity in multiple sclerosis. Immunol. Today 16:259.
5. Freeman, M., and A. P. Weetman. 1992. T and B cell reactivity to adrenal antigens in autoimmune Addison's disease. Clin. Exp. Immunol. 88:275.
6. Gepts, W., and P. M. Lecompte. 1981. The pancreatic islets in diabetes. Am. J. Med. 70:105.
7. Foulis, A. D., and J. A. Stewart. 1984. The pancreas in recent-onset type 1 (insulin-dependent) diabetes mellitus: insulin content of islets, insulitis and associated changes in the exocrine acinar tissue. Diabetologia 26:456.
8. + T cell dependent. J. Immunol. 146:85.
9. + T-cell clones derived from lymphocytes infiltrating the islets of NOD mice. Diabetes 41:998.
10. Haskins, K., M. Portas, B. Bradley, D. Wegmann, and K. Lafferty. 1988. T lymphocyte clone specific for pancreatic islet antigen. Diabetes 31:1444.
11. + T cells. J. Exp. Med. 166:823.
12. + T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J. Immunol. 140:52.
13. Lampeter, E. F., M. Homberg, K. Quabeck, U. W. Schaefer, P. Wernet, J. Bertrams, H. Grosse-Wilde, F. A. Gries, and H. Kolb. 1993. Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation. Lancet 341:1243.
14. Palmer, J. P. 1993. Predicting IDDM: Use of humoral immune markers. Diabetes Rev. 1:104.
15. Greenbaum, C. J., B. M. Brooks-Worrell, J. P. Palmer, and A. Lernmark. 1994. Autoimmunity and predication of insulin dependent diabetes mellitus. In Diabetes Annual/8. S. M. Marshall and P. D. Home, eds, Elsevier Science BV, Amsterdam, p. 21.
16. Bieg, A., E. M. Bailyes, N. Yassin, J. Amann, L. Herberg, A. M. McGregor, W. A. Scherbaum, and J. P. Banga. 1993. A multiplicity of protein antigens in subcellular fractions of rat insulinoma tissue are able to stimulate T cells obtained from non-obese diabetic mice. Diabetologia 36:385.
17. Gelber, C., L. Paborsky, S. Singer, D. McAteer, R. Tisch, C. Jolicoeur, R. Buelow, H. McDevitt, and C. G. Fathman. 1994. Isolation of nonobese diabetic mouse T cells that recognize novel autoantigens involved in the early events of diabetes. Diabetes 43:33.
18. Roep, B. O., S. D. Arden, R. R. P. deVries, and J. C. Hutton. 1989 Human T cell clones with specificity for insulinoma cell antigens. Eur. J. Immunol. 19:213.
19. Atkinson, M. A., L. Campbell, S. C. Shah, M. G. Erlander, D. L. Kaufman, K. A. Gibbs, D.-F. Bu, A. J. Tobin, and N. K. Maclaren. 1992. Response of peripheral blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet 339:458.
20. Honeyman, M. C., D. S. Cram, and L. C. Harrison. 1992. Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin-dependent diabetes. J. Exp. Med. 177:535.
21. Harrison, H. C., M. C. Honeyman, H. J. HeAizpurua, R. S. Schmidli, P. G. Colman, B. D. Tait, and D. S. Cram. 1993. Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin dependent diabetes. Lancet 341:1365.
22. Atkinson, M. A., M. A. Bowman, L. Campbell, B. L. Darrow, K. L. Kaufman, and N. K. Maclaren. 1994. Cellular immunity to a determinant common to glutamate decarboxylase and Coxsackie virus in insulin-dependent diabetes. J. Clin. Invest. 94:2125.
23. Naquet, P., J. Ellis, D. Tibenski, A. Kennshole, B. Singh, R. Hodges, and T. L. Delovitch. 1988. T cell autoreactivity to insulin in diabetic and related non-diabetic individuals. J. Immunol. 140:2569.
24. Roep, B. O., S. D. Arden, R. R. deVries, and J. C. Hutton. 1990. T cell clones from a type 1 diabetic patient respond to insulin secretory granule proteins. Nature 345:632.
25. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:6880.
26. Abou-Zeid, C., E. Filley, J. Steele, and B. A. W. Rook. 1987. A simple new method for using antigens separated by polyacrylamide gel electrophoresis to stimulate lymphocytes in vitro after converting bands cut from western blots into antigen-bearing particles. J. Immunol. Methods 98:5.
27. Arden, D. S., B. O. Roep, D. I. Neophytou, E. F. Usac, G. Duinkerken, R. R. P. deVries, and J. C. Hutton. 1996. Imunogen 38: a novel 38 kd islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient. J. Clin. Invest. 97:551.
28. Roep, B. O., A. A. Kallan, G. Duinkerken, S. D. Arden, J. C. Hutton, G. J. Bruining, and R. R. P. deVries. 1995. T-cell reactivity to beta-cell membrane antigens associated with beta-cell destruction in IDDM. Diabetes 44:278.
29. Brooks-Worrell, B., and G. A. Splitter. 1992. Brucella abortus strain 19 antigens immunodominant for bovine lymphocytes as identified by one- and two-dimensional cellular immunoblotting. Infect. Immun. 60:2459.
30. Lamb, J. R., and D. B. Young. 1987. A novel approach to the identification of T cell epitopes in Mycabacterium tuberculosis using human T-lymphocytes clones. Immunology 60:1.
31. Pham, B J., L. Prin, D. Gosset, P. Y. Hatron, B. Devulder, A. Capron, and J. P. Dessaint. 1989. T lymphocyte activation in systemic lupus erythematosus analysed by proliferative response to nucleoplasmic proteins on nitrocellulose immunoblot. Clin. Exp. Immunol. 77:168.
32. Neumann, D. A., N. R. Rose, A. A. Ansari, and A. Herskowitz. 1994. Induction of multiple heart autoantibodies in mice with Coxsackievirus B3 and cardiac myosin-induced autoimmune myocarditis. J. Immunol. 152:343.
33. Sakamoto, Y., T. Matsumoto, Y. Mizunoe, M. Haraoka, M. Sakumoto, and J. Kumazawa. 1995. Testicular injury induces cell-mediated autoimmune response to testis. J. Urol. 153:1316.