3,5-Diarylazoles as novel and selective inhibitors of protein kinase D

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 5, 2011, Pages 1447-1451

  Gamber, Gabriel G ^a   Meredith, Erik ^a   Zhu, Qingming ^a   Yan, Wanlin ^a   Rao, Chang ^a   Capparelli, Michael ^a   Burgis, Robin ^a   Enyedy, Istvan ^a   Zhang, Ji Hu ^a   Soldermann, Nicolas ^a   Beattie, Kimberley ^a   Rozhitskaya, Olga ^a   Koch, Keith A ^b   Pagratis, Nikos ^b   Hosagrahara, Vinayak ^a   Vega, Richard B ^a   McKinsey, Timothy A ^b   Monovich, Lauren ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b Gilead Colorado Inc   (United States)

Author keywords

Cardiac hypertrophy; Heart failure; Histone deacetylase; Kinase inhibitor; PKD; Protein kinase D

Indexed keywords

3,5 DIARYLAZOLE; HISTONE DEACETYLASE 5; PROTEIN KINASE D; PROTEIN KINASE INHIBITOR; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL ASSAY; ENZYME INHIBITION; NUCLEAR EXPORT SIGNAL; PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; AZOLES; BIOLOGICAL AVAILABILITY; HISTONE DEACETYLASES; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79951687978     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.01.014     Document Type: Article

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