CYP2B6 gene single nucleotide polymorphisms and leukemia susceptibility

Annals of Hematology

Volumn 90, Issue 3, 2011, Pages 293-299

  Yuan, Zhong Hai ^a,b   Liu, Qian ^a   Zhang, Ying ^a   Liu, Hong Xing ^c   Zhao, Jun ^a   Zhu, Ping ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b JILIN MEDICAL COLLEGE   (China)

^c Beijing Dao pei Hospital   (China)

Author keywords

Acute leukemia; Cytochrome P450 2B6; Gene polymorphism; Myelodysplastic syndrome

Indexed keywords

CYTOCHROME P450 2B6;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE MONOCYTIC LEUKEMIA; ADOLESCENT; ADULT; ARTICLE; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CHILD; CHROMOSOME ABERRATION; CONTROLLED STUDY; FEMALE; GEL ELECTROPHORESIS; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; KARYOTYPING; MAJOR CLINICAL STUDY; MALE; MUTATION RATE; MUTATIONAL ANALYSIS; MYELODYSPLASTIC SYNDROME; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR; SCHOOL CHILD; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; UMBILICAL CORD BLOOD;

ALLELES; ARYL HYDROCARBON HYDROXYLASES; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KARYOTYPING; LEUKEMIA, MYELOID, ACUTE; MYELODYSPLASTIC SYNDROMES; OXIDOREDUCTASES, N-DEMETHYLATING; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RISK FACTORS;

EID: 79951679490     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-010-1085-z     Document Type: Article

References (45)

1. M Aydin-Sayitoglu O Hatirnaz N Erensoy U Ozbek 2006 Role of CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 genes in the susceptibility to acute leukemias Am J Hematol 81 162 170 1:CAS:528:DC%2BD28XivV2mtrs%3D 10.1002/ajh.20434 16493615
2. S Ekins SA Wrighton 1999 The role of CYP2B6 in human xenobiotic metabolism Drug Metab Rev 31 719 754 1:CAS:528:DyaK1MXlvVKmsLc%3D 10.1081/DMR-100101942 10461547 (Pubitemid 29390407)
3. V Lamba J Lamba K Yasuda S Strom J Davila ML Hancock, et al. 2003 Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression J Pharmacol Exp Ther 307 906 922 1:CAS:528:DC%2BD3sXpslShs7c%3D 10.1124/jpet.103.054866 14551287 (Pubitemid 37494207)
4. P Roy LJ Yu CL Crespi DJ Waxman 1999 Development of a substrate-activity based approach to identify the major human liver P-450 catalysis of cyclophosphamide and ifosphamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles Drug Metab Dispos 27 655 666 1:CAS:528:DyaK1MXjs1eltbY%3D 10348794 (Pubitemid 29252439)
5. MH Court SX Duan LM Hesse K Venkatakrishnan DJ Greenlbatt 2001 Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes Anesthesiology 94 110 119 1:CAS:528:DC%2BD3MXmsFKjtQ%3D%3D 10.1097/00000542-200101000-00021 11135730 (Pubitemid 32055186)
6. LM Hesse K Venkatakrishnan MH Court LL von Moltke SX Duan RI Shader, et al. 2000 CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants Drug Metab Dispos 28 1176 1183 1:CAS:528:DC%2BD3cXntVSltrs%3D 10997936
7. J Wang A Sönnerborg A Rane F Josephson S Lundgren L Ståhle, et al. 2006 Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz Pharmacogenet Genomics 16 191 198 10.1097/01.fpc.0000230119.34205.8a 16495778 (Pubitemid 44454868)
8. E Hodgson RL Rose 2007 The importance of cytochrome P450 2B6 in the human metabolism of environmental chemicals Pharmacol Ther 113 420 428 1:CAS:528:DC%2BD2sXhtVCgtbs%3D 10.1016/j.pharmthera.2006.10.002 17157385 (Pubitemid 46149054)
9. EL Code CL Crespi BW Penman FJ Gonzalez TK Chang DJ Waxman 1997 Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation Drug Metab Dispos 25 985 993 1:CAS:528:DyaK2sXlsVGmsrc%3D 9280407 (Pubitemid 27357697)
10. SM Hoffman DR Nelson DS Keeney 2001 Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19 Pharmacogenetics 11 687 698 1:CAS:528:DC%2BD38XnsFKrurk%3D 10.1097/00008571-200111000-00007 11692077 (Pubitemid 33078238)
11. MH Hofmann JK Blievernicht K Klein T Saussele E Schaeffeler M Schwab, et al. 2008 Aberrant splicing caused by single nucleotide polymorphism 516G>T [Q172H], a marker of CYP2B6*6, is responsible for decreased expression and activity of CYP2B6 in liver J Pharmacol Exp Ther 325 1 284 292 1:CAS:528:DC%2BD1cXktFGjtbc%3D 10.1124/jpet.107.133306 18171905 (Pubitemid 351439175)
12. M Berköz S Yalin 2009 Association of CYP2B6 G15631T polymorphism with acute leukemia susceptibility Leuk Res 33 7 919 923 10.1016/j.leukres.2008. 11.014 10.1016/j.leukres.2008.11.014 19144407
13. M Poncz D Solowiejczyk B Harpel Y Mory E Schwartz S Surrey 1982 Construction of human gene libraries from small amounts of peripheral blood: analysis of beta-like globin genes Hemoglobin 6 27 36 1:CAS:528: DyaL38XhvFCnsLc%3D 10.3109/03630268208996930 7068433 (Pubitemid 12149315)
14. L Zhigang W Minyuan Z Ping, et al. 2001 Analysis of fused genes resulting from 29 chromosomal aberrations in leukemia Chin J Pediatr 39 11 682 685
15. J Cui J Wang K He B Jin H Wang W Li, et al. 2004 Proteomic analysis of human acute leukemia cells Clin Cancer Res 10 6887 6896 1:CAS:528: DC%2BD2cXpslGltb8%3D 10.1158/1078-0432.CCR-04-0307 15501966 (Pubitemid 39383038)
16. DT Bowen ME Frew S Rollinson PL Roddam A Dring MT Smith, et al. 2003 CYP1A1*2B(val) allele is overpresented in subgroup of acute myeloid leukemia with poor-risk karyotype associated with NRAS mutation, but not associated with FLT3 internal tandem duplication Blood 101 2770 2774 1:CAS:528:DC%2BD3sXivVWns70%3D 10.1182/blood-2002-01-0228 12468438 (Pubitemid 36857642)
17. CH Pui S Sallan MV Relling G Masera WE Evans 2001 International childhood acute lymphocytic leukemia workshop: Sausalito, CA, 30 November-1 December 2000 Leukemia 15 707 715 1:STN:280:DC%2BD3M3ntlKmtw%3D%3D 10.1038/sj.leu.2402111 11368430 (Pubitemid 32492693)
18. LM Dong JD Potter E White CM Ulrich LR Cardon U Peters 2008 Genetic susceptibility to cancer: the role of polymorphisms in candidate genes JAMA 299 2423 2436 1:CAS:528:DC%2BD1cXmsFGitL4%3D 10.1001/jama.299.20.2423 18505952 (Pubitemid 351749241)
19. M Krajinovic D Labuda D Sinnett 2001 Childhood acute lymphoblastic leukemia: genetic determinants of susceptibility and disease outcome Rev Environ Health 16 263 279 1:CAS:528:DC%2BD38XjvFOhtLg%3D 12041882 (Pubitemid 34453326)
20. JA Agundez 2004 Cytochrome P450 gene polymorphism and cancer Curr Drug Metab 5 211 224 1:CAS:528:DC%2BD2cXktlKksrk%3D 10.2174/1389200043335621 15180491 (Pubitemid 38735776)
21. GA Belitsky MG Yakubovskaya 2008 Genetic polymorphism and variability of chemical carcinogenesis Biochem Moscow 73 543 554 1:CAS:528:DC%2BD1cXmsFKhtb0%3D 10.1134/S0006297908050076 (Pubitemid 351775077)
22. M Belson B Kingsley A Holmes 2007 Risk factors for acute leukemia in children Environ Health Perspect 115 138 145 1:CAS:528:DC%2BD2sXhsVOlurc%3D 10.1289/ehp.9023 17366834 (Pubitemid 46050296)
23. TK Eyada EG El Ghonemy EA El Ghoroury SO El Bassyouni MK El Masry 2007 Study of genetic polymorphism of xenobiotic enzymes in acute leukemia Blood Coagul Fibrinolysis 18 489 495 1:CAS:528:DC%2BD2sXmslSqsrk%3D 10.1097/MBC.0b013e3281eec930 17581325 (Pubitemid 46975953)
24. D Sinnett M Krajinovic D Labuda 2000 Genetic susceptibility to childhood acute lymphoblastic leukemia Leuk Lymphoma 38 447 462 1:CAS:528:DC%2BD3MXhsFal 10.3109/10428190009059264 10953966 (Pubitemid 30614530)
25. H Kim RS Wang E Elovaara H Raunio O Pelkonen T Aoyama, et al. 1997 Cytochrome P450 isozymes responsible for the metabolismof toluene and styrene in human liver microsomes Xenobiotica 27 657 665 1:CAS:528:DyaK2sXkvFCntrg%3D 10.1080/004982597240253 9253143 (Pubitemid 27301402)
26. S Miksys C Lerman PG Shields DC Mash RF Tyndale 2003 Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain Neuropharmacology 45 122 132 1:CAS:528:DC%2BD3sXks1als74%3D 10.1016/S0028-3908(03)00136-9 12814665 (Pubitemid 36700458)
27. MT Baker MJ Olson Y Wang WC Ronnenberg Jr JT Johnson AN Brady 1995 Isoflurane-chlorodifluoroethene interaction in human liver microsomes. Role of cytochrome P4502B6 in potentiation of haloethene metabolism Drug Metab Dispos 23 60 64 1:CAS:528:DyaK2MXjtVOrtLs%3D 7720526
28. C Rodriguez-Antona M Ingelman-Sundberg 2006 Cytochrome P450 pharmacogenetics and cancer Oncogene 25 1679 1691 1:CAS:528:DC%2BD28XisFyhtbY%3D 10.1038/sj.onc.1209377 16550168
29. US Simonsson B Jansson TN Hai DX Huong G Tybring M Ashton 2003 Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9 Clin Pharmacol Ther 74 32 43 1:CAS:528:DC%2BD3sXkvFGhsLY%3D 10.1016/S0009-9236(03)00092-4 12844133 (Pubitemid 36776174)
30. H Rosenbrock CE Hagemeyer I Singec R Knoth B Volk 1999 Testosterone metabolism in rat brain is differentially enhanced by phenytoin-inducible cytochrome P450 isoforms J Neuroendocrinol 11 597 604 1:CAS:528: DyaK1MXltFCgtL0%3D 10.1046/j.1365-2826.1999.00371.x 10447797 (Pubitemid 29338675)
31. KA Schoedel EM Sellers R Palmour RF Tyndale 2003 Down-regulation of hepatic nicotine metabolism and a CYP2B6-like enzyme in African green monkeys after long-term nicotine administration Mol Pharmacol 63 96 104 1:CAS:528:DC%2BD3sXjsVKm 10.1124/mol.63.1.96 12488541 (Pubitemid 36043813)
32. M Turpeinen H Raunio O Pelkonen 2006 The functional role of CYP2B6 in human drug metabolism: substrates and inhibitors in vitro, in vivo and in silico Curr Drug Metab 7 705 714 1:CAS:528:DC%2BD28XhtVWgt7rE 10.2174/ 138920006778520633 17073575 (Pubitemid 44509677)
33. K Tong ML He CK Lin L Guo HF Kung JJ Sung, et al. 2006 The implications of a high allelic frequency of CYP2B6 G516T in ethnic Chinese persons Clin Infect Dis 43 541 542 10.1086/505984 16838248 (Pubitemid 44157168)
34. S Rodriguez-Novoa P Barreiro A Rendon I Jimenez-Nacher J Gonzalez-Lahoz V Soriano 2005 Influence of 516G>T polymorphisms at the gene encoding the CYP450-2B6 isoenzyme on efavirenz plasma concentrations in HIV-infected subjects Clin Infect Dis 40 1358 1361 1:CAS:528:DC%2BD2MXktlajsrg%3D 10.1086/429327 15825040 (Pubitemid 40570249)
35. UM Zanger K Klein T Saussele J Blievernicht MH Hofmann M Schwab 2007 Polymorphic CYP2B6: molecular mechanisms and emerging clinical significance Pharmacogenomics 8 743 759 1:CAS:528:DC%2BD2sXnvVertrw%3D 10.2217/14622416.8.7. 743 17638512 (Pubitemid 47288975)
36. J Davaalkham T Hayashida K Tsuchiya H Gatanaga D Nyamkhuu S Oka 2009 Allele and genotype frequencies of cytochrome P450 2B6 gene in a Mongolian population Drug Metab Dispos 37 10 1991 1993 1:CAS:528:DC%2BD1MXht1amsLjE 10.1124/dmd.109.027755 19581387
37. BY Xu LP Guo SS Lee QM Dong Y Tan H Yao, et al. 2007 Genetic variability of CYP2B6 polymorphisms in four southern Chinese populations World J Gastroenterol 13 14 2100 2103 1:CAS:528:DC%2BD2sXmsFOnsrc%3D 17465455 (Pubitemid 46795849)
38. K Klein T Lang T Saussele E Barbosa-Sicard WH Schunck M Eichelbaum, et al. 2005 Genetic variability of CYP2B6 in populations of African and Asian origin: allele frequencies, novel functional variants, and possible implications for anti-HIV therapy with efavirenz Pharmacogenet Genomics 15 861 873 1:CAS:528:DC%2BD2MXhtFymtL3M 10.1097/01213011-200512000-00004 16272958 (Pubitemid 41666768)
39. K Cohen A Grant C Dandara H McIlleron L Pemba K Fielding, et al. 2009 Effect of rifampicin-based antitubercular therapy and the cytochrome P450 2B6 516G>T polymorphism on efavirenz concentrations in adults in South Africa Antivir Ther 14 5 687 695 1:CAS:528:DC%2BD1MXht1SntLfK 19704172
40. S Chantarangsu TR Cressey S Mahasirimongkol E Capparelli Y Tawon N Ngo-Giang-Huong, et al. 2009 Influence of CYP2B6 polymorphisms on the persistence of plasma nevirapine concentrations following a single intra-partum dose for the prevention of mother to child transmission in HIV-infected Thai women J Antimicrob Chemother 64 6 1265 1273 1:CAS:528:DC%2BD1MXhsVWqtL3P 10.1093/jac/dkp351 19812066
41. T Puthanakit P Tanpaiboon L Aurpibul TR Cressey V Sirisanthana 2009 Plasma efavirenz concentrations and the association with CYP2B6-516G>T polymorphism in HIV-infected Thai children Antivir Ther 14 3 315 320 1:CAS:528:DC%2BD1MXotFSrsbs%3D 19474465
42. A Kwara M Lartey KW Sagoe NL Rzek MH Court 2009 CYP2B6 (c.516G- > T) and CYP2A6 (*9B and/or*17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients Br J Clin Pharmacol 67 4 427 436 1:CAS:528:DC%2BD1MXlvFSjurc%3D 10.1111/j.1365-2125.2009.03368.x 19371316
43. G Ramachandran K Ramesh AK Hemanth Kumar I Jagan M Vasantha C Padmapriyadarsini, et al. 2009 Association of high T allele frequency of CYP2B6 G516T polymorphism among ethnic south Indian HIV-infected patients with elevated plasma efavirenz and nevirapine J Antimicrob Chemother 63 4 841 843 1:CAS:528:DC%2BD1MXjt1GjsbY%3D 10.1093/jac/dkp033 19218571
44. T Joseph P Kusumakumary P Chacko A Abraham M Radhakrishna Pillai 2004 Genetic polymorphismof CYP1A1, CYP2D6, GSTM1 and GSTT1 and susceptibility to acute lymphoblastic leukaemia in Indian children Pediatr Blood Cancer 43 560 567 10.1002/pbc.20074 15382273 (Pubitemid 39313955)
45. MC Lemos FJ Cabrita HA Silva M Vivan F Plácido FJ Regateiro 1999 Genetic polymorphism of CYP2D6, GSTM1 and NAT2 and susceptibility to haematological neoplasias Carcinogenesis 20 1225 1229 1:CAS:528: DyaK1MXkslGhsr0%3D 10.1093/carcin/20.7.1225 10383893 (Pubitemid 29341442)