Atorvastatin neutralises the thrombin-induced tissue factor expresion in endothelial cells via geranylgeranyl pyrophosphate

Cytotechnology

Volumn 63, Issue 1, 2011, Pages 1-5

  Martínez Sales, Vicenta ^a   Vila, Virtudes ^a   Ferrando, Marcos ^a   Reganon, Edelmiro ^a  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

Atorvastatin; Endothelial cells; Geranylgeranyl pyrophosphate; Thrombin; Tissue factor

Indexed keywords

ATORVASTATIN; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; MEVALONIC ACID; THROMBIN; THROMBOPLASTIN;

ARTICLE; CELL STIMULATION; DRUG ANTAGONISM; DRUG INHIBITION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; REGULATORY MECHANISM; UPREGULATION;

EID: 79951677100     PISSN: 09209069     EISSN: 15730778     Source Type: Journal    
DOI: 10.1007/s10616-010-9319-4     Document Type: Article

References (13)

1. P Adamson CJ Marshall A Hall PA Tilbrook 1992 Post-translational modifications of p21rho proteins J Biol Chem 267 20033 20038 1:CAS:528:DyaK38XlsVGlsbk%3D
2. DD Cilla Jr LR Whitfield DM Gibson AJ Sedman EL Posvar 1996 Multiple-dose pharmacokinetics, pharmacodynamics, and safety of atorvastatin, an inhibitor of HMG-CoA reductase, in healthy subjects Clin Pharmacol Ther 60 687 695 1:CAS:528:DyaK2sXms1CjsA%3D%3D 10.1016/S0009-9236(96)90218-0 (Pubitemid 27025917)
3. PA Edwards J Ericsson 1999 Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway Annu Rev Biochem 68 157 185 1:CAS:528:DyaK1MXlvFajs7c%3D 10.1146/annurev.biochem.68.1.157 (Pubitemid 29449190)
4. M Eto T Kozai F Cosentino H Joch TF Lüscher 2002 Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways Circulation 105 1729 1756 10.1161/01.CIR.0000015465.73933.3B (Pubitemid 34408880)
5. D Ferro S Basili C Alessandri D Cara F Violi 2000 Inhibition of tissue-factor-mediated thrombin generation by simvastatin Atherosclerosis 149 111 116 1:CAS:528:DC%2BD3cXhsVagu7w%3D 10.1016/S0021-9150(99)00291-9 (Pubitemid 30125978)
6. T Ishibashi T Sakamoto H Ohkawara K Nagata K Sugimoto S Sakurada N Sugimoto A Watanabe K Yokoyama N Sakamoto M Kurabayashi Y Takuwa Y Maruyama 2003 Integral role of RhoA activation in monocyte adhesion-triggered tissue factor expression in endothelial cells Ateroscler Thromb Vasc Biol 23 681 687 1:CAS:528:DC%2BD3sXisFKgtbk%3D 10.1161/01.ATV.0000065194.00822.C7 (Pubitemid 36438084)
7. Y Kunieda K Nakagawa H Nishimura H Kato N Ukimura S Yano H Kawano S Kimura M Nakagawa H Tsuji 2003 HMG CoA reductase inhibitor suppresses the expression of tissue factor and plasminogen activator inhibitor-1 induced by angiotensin II in cultured rat aortic endothelial cells Thromb Res 110 227 234 1:CAS:528:DC%2BD3sXnsVKgsro%3D 10.1016/S0049-3848(03)00346-3 (Pubitemid 37338298)
8. JQ Li SP Zhao QZ Li YC Cai LR Wu Y Fang P Li 2007 Atorvastatin reduces tissue factor expression in adipose tissue of atherosclerotic rabbits Int J Cardiol 115 229 234 10.1016/j.ijcard.2006.02.007 (Pubitemid 46136524)
9. V Martínez-Sales V Vila M Ferrando E Reganon 2007 Atorvastatin neutralizes the up-regulation of thrombospondin-1 induced by thrombin in human umbilical vein endothelial cells Endothelium 14 233 238 (Pubitemid 47543009)
10. H Ohkawara T Ishibashi T Sakamoto K Sugimoto K Nagata K Yokoyama N Sakamoto M Kamioka I Matsuoka S Fukuhara N Sugimoto Y Takuwa Y Maruyama 2005 Thrombin-induced rapid geranyl geranylation of RhoA as an essential process for RhoA activation in endothelial cells J Biol Chem 280 10182 10188 1:CAS:528:DC%2BD2MXit1ekurs%3D 10.1074/jbc.M409547200 (Pubitemid 40395872)
11. HJ Park D Kong ML Iruela-Arispe U Begley D Tang JB Galper 2002 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA Cir Res 91 143 150 1:CAS:528:DC%2BD38XlvVCgsL8%3D 10.1161/01.RES.0000028149.15986.4C (Pubitemid 34827225)
12. B Tesfamariam 2006 The effects of HMG-CoA reductase inhibitors on endothelial cells Am J Cardiovasc Drugs 6 115 120 1:CAS:528:DC%2BD28XlvVSqu7k%3D 10.2165/00129784-200606020-00005
13. JJ Zhang RJ Kelm P Biswas M Kashgarian JA Madri 2007 PECAM-1 modulates thrombin-induced tissue factor expression on endothelial cells J Cell Physiol 210 527 537 1:CAS:528:DC%2BD28XhtlGqsbfJ 10.1002/jcp.20908 (Pubitemid 44970427)