Ileal immune dysregulation in necrotizing enterocolitis: Role of CD40/CD40L in the pathogenesis of disease

Journal of Pediatric Gastroenterology and Nutrition

Volumn 52, Issue 2, 2011, Pages 140-146

  Xu, Jiliu ^a   Treem, William R ^a   Roman, Christopher ^b   Anderson, Virginia ^a   Rubenstein, Richard ^c   Schwarz, Steven M ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b Cell Biology   (United States)

^c KINGS COUNTY HOSPITAL CENTER   (United States)

Author keywords

CD40; CD40 ligand; IL 10; IL 10R ; ileum

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; EPIDERMAL GROWTH FACTOR; INTERLEUKIN 10 RECEPTOR BETA; INTERLEUKIN 18; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; ASPHYXIA; CELL INFILTRATION; COLD STRESS; CONTROLLED STUDY; DISEASE SEVERITY; FEEDING; ILEUM; IMMUNE DYSREGULATION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MONOCYTE; NECROTIZING ENTEROCOLITIS; NEWBORN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD40; BLOTTING, WESTERN; CD40 LIGAND; ENTEROCOLITIS, NECROTIZING; EPIDERMAL GROWTH FACTOR; ILEUM; INFLAMMATION; INTERLEUKIN-10 RECEPTOR BETA SUBUNIT; INTERLEUKIN-18; MACROPHAGES; MODELS, ANIMAL; MONOCYTES; RATS; RATS, SPRAGUE-DAWLEY; T-LYMPHOCYTES; TOLL-LIKE RECEPTOR 4;

ANIMALIA; RATTUS;

EID: 79951676065     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPG.0b013e3182039bad     Document Type: Article

References (35)

1. Uauy RD, Fanaroff AA, Korones SB, et al. Necrotizing enterocolitis in very low birth weight infants: biodemographic and clinical correlates. J Pediatr 1991;119:630-8.
2. Caplan MS, MacKendrick W. Necrotizing enterocolitis: a review of pathogenetic mechanisms and implications for prevention. Pediatr Pathol 1993;13:357-69. (Pubitemid 23183054)
3. Caplan MS, Simon D, Jilling T. The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis. Semin Pediatr Surg 2005;14:145-51. (Pubitemid 41111600)
4. Edelson MB, Bagwell CE, Rozycki HJ. Circulating pro- and counter-inflammatory cytokine levels and severity in necrotizing enterocolitis. Pediatrics 1999;103:766-71. (Pubitemid 29274469)
5. Caplan MS, Sun XM, Hseuh W, et al. Role of platelet activating factor and tumor necrosis factor-alpha in neonatal necrotizing enterocolitis. J Pediatr 1990;116:960-4. (Pubitemid 20201711)
6. Harris MC, D'Angio CT, Gallagher PR, et al. Cytokine elaboration in critically ill infants with bacterial sepsis, necrotizing entercolitis, or sepsis syndrome: correlation with clinical parameters of inflammation and mortality. J Pediatr 2005;147:462-8. (Pubitemid 41446539)
7. Harris MC, Costarino AT Jr, Sullivan JS, et al. Cytokine elevations in critically ill infants with sepsis and necrotizing enterocolitis. J Pediatr 1994;124:105-11. (Pubitemid 24027297)
8. Fituch CC, Palkowetz KH, Goldman AS, et al. Concentrations of IL-10 in preterm human milk and in milk from mothers of infants with necrotizing enterocolitis. Acta Paediatr 2004;93:1496-500. (Pubitemid 39457066)
9. Dvorak B, Halpern MD, Holubec H, et al. Maternal milk reduces severity of necrotizing enterocolitis and increases intestinal IL-10 in a neonatal rat model. Pediatr Res 2003;53:426-33. (Pubitemid 36237397)
10. Frost BL, Jilling T, Caplan MS, et al. The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis. Semin Perinatol 2008;32:100-6. (Pubitemid 351381163)
11. de La Cochetière MF, Rougé C, Darmaun D, et al. Intestinal microbiota in neonates and preterm infants: a review. Curr Pediatr Rev 2007;3:21-34. (Pubitemid 46322321)
12. Reichmann G, Walker W, Villegas EN, et al. The CD40/CD40 ligand interaction is required for resistance to toxoplasmic encephalitis. Infect Immun 2000;68:1312-8. (Pubitemid 30108527)
13. Habib M, Rivas MN, Chamekh M, et al. Cutting edge: small molecule CD40 ligand mimetics promote control of parasitemia and enhance T cells producing IFN-gamma during experimental Trypanosoma cruzi infection. J Immunol 2007;178:6700-4. (Pubitemid 46847390)
14. MacDonald AS, Patton EA, La Flamme AC, et al. Impaired Th2 development and increased mortality during Schistosoma mansoni infection in the absence of CD40/CD154 interaction. J Immunol 2002; 168:4643-9. (Pubitemid 34441371)
15. Kooten CV, Banchereau J. CD40-CD40 ligand. J Leukocyte Biol 2000; 67:2-17. (Pubitemid 30046812)
16. Cosyns M, Tsirkin S, Jones M, et al. Requirement for CD40-CD40l interaction for elimination of Cryptosporidium parvum from mice. Infect Immun 1998;66:603-7. (Pubitemid 28074201)
17. Mathur RK, Awasthi A, Wadhone P, et al. Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses. Nat Med 2004;10:540-4. (Pubitemid 38667915)
18. Murugaiyan G, Agrawal R, Mishra GC, et al. Functional dichotomy in CD40 reciprocally regulates effector T cell functions. J Immunol 2006;177:6642-9. (Pubitemid 44715027)
19. Dvorak B, Halpern MD, Holubec H, et al. Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model. Am J Physiol Gastrointest Liver Physiol 2002;282:156-64.
20. Murai1 M, Turovskaya1 O, Kim G, et al. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol 2009;10:1178-84.
21. Feng J, El-Assal ON, Besner GE, et al. Heparin-binding epidermal growth factor-like growth factor reduces intestinal apoptosis in neonatal rats with necrotizing enterocolitis. J Pediatr Surg 2006;41:742-7.
22. Halpern MD, Holubec H, Dominguez JA, et al. Up-regulation of IL-18 and IL-12 in the ileum of neonatal rats with necrotizing enterocolitis. Pediatr Res 2002;51:733-9. (Pubitemid 34547337)
23. Schultz AM, Bonnard A, Barreau F, et al. Expression of TLR-2, TLR-4, NOD2 and pNF-(B in a neonatal rat model of necrotizing enterocolitis. PLoS ONE 2007;2:e1102.
24. Dvorak B, Khailova L, Clark JA, et al. Comparison of epidermal growth factor and heparin-binding epidermal growth factor-like growth Factor for prevention of experimental necrotizing enterocolitis. J Pediatr Gastroenterol Nutr 2008;47:11-8.
25. Danese S, Sans M, Fiocchi C. The CD40/CD40L costimulatory pathway in inflammatory bowel disease. Gut 2004;53:1035-43. (Pubitemid 38824165)
26. Jiu Z, Colpaert S, D'Haens GR, et al. Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production. J Immunol 1999;163:4049-57. (Pubitemid 29450936)
27. Clark EA, Ledbetter JA. Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50. Proc Natl Acad Sci U S A 1986;83:4494-8. (Pubitemid 16057075)
28. Van KC, Banchereau J. CD40-CD40 ligand: a multifunctional receptor-ligand pair. Adv Immunol 1996;61:1-77. (Pubitemid 26065039)
29. Borcherding F, Nitschke M, Hundorfean G, et al. The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cellsin inflammatory bowel disease. Am J Pathol 2010;176:1816-27.
30. Lotz M, Gutle D, Walther S, et al. Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells. J Exp Med 2006;203:973-84.
31. Chan KL, Ho JC, Chan KW, et al. A study of gut immunity to enteral endotoxin in rats of different ages: a possible cause for necrotizing enterocolitis. J Pediatr Surg 2002;37:1435-40.
32. Jilling R, Simon D, Lu J, et al. The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J Immunol 2006;177:3273-82. (Pubitemid 44277847)
33. Schoenberger SP, Toes RE, van der Voort EI, et al. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 1998;393:480-3.
34. Bennett SR, Carbone FR, Karamalis F, et al. Help for cytotoxic-T-cell responses is mediated by CD40 signaling. Nature 1998;393:478-80.
35. Ridge JP, Di Rosa F, Matzinger P, et al. A conditioned dendritic cell can be a temporal bridge between a CD4 T-helper and a T-killer cell. Nature 1998;393:474-8.