Ghrelin as a promising therapeutic target for co-occurring autism and epilepsy

Epilepsy and Behavior

Volumn 20, Issue 2, 2011, Pages 420-421

  Ghanizadeh, Ahmad ^a  

^a SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ANTICONVULSIVE AGENT; CARBAMAZEPINE; GHRELIN; GLUTAMIC ACID; NEUROPEPTIDE Y; VALPROIC ACID;

APOPTOSIS; AUTISM; EPILEPSY; EXCITATION; HUMAN; INHIBITION KINETICS; LETTER; NERVOUS SYSTEM INFLAMMATION; PROTEIN EXPRESSION;

AUTISTIC DISORDER; EPILEPSY; GHRELIN; HUMANS;

EID: 79951675740     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2010.12.009     Document Type: Letter

References (26)

1. Mouridsen S.E., Rich B., Isager T. A longitudinal study of epilepsy and other central nervous system diseases in individuals with and without a history of infantile autism. Brain Dev July 22 2010, [EPub ahead of print]. doi:10.1016/j.braindev.2010.07.002.
2. Canitano R. Epilepsy in autism spectrum disorders. Eur Child Adolesc Psychiatry 2007, 16:61-66.
3. Pintaudi M., Calevo M.G., Vignoli A., et al. Epilepsy in Rett syndrome: clinical and genetic features. Epilepsy Behav 2010, 19:296-300.
4. Ghanizadeh A. Leptin as a new approach for treatment for autism and epilepsy, a hypothesis with clinical implications. Brain Dev 2011, 33:92.
5. Rubenstein J.L., Merzenich M.M. Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes Brain Behav 2003, 2:255-267.
6. Chez M.G., Burton Q., Dowling T., Chang M., Khanna P., Kramer C. Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: an observation of initial clinical response and maintenance tolerability. J Child Neurol 2007, 22:574-579.
7. Ghanizadeh A. c-kit+ cells transplantation as a new treatment for autism, a novel hypothesis with important research and clinical implication. J Autism Dev Disord in press.
8. Ghanizadeh A. Transplantation of GABAergic cell line as a novel hypothesized treatment for autism. Epilepsy Behav 2010, 19:664.
9. Oblak A.L., Gibbs T.T., Blatt G.J. Decreased GABA(B) receptors in the cingulate cortex and fusiform gyrus in autism. J Neurochem 2010, 114:1414-1423.
10. Vargas D.L., Nascimbene C., Krishnan C., Zimmerman A.W., Pardo C.A. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol 2005, 57:67-81.
11. Pardo C.A., Vargas D.L., Zimmerman A.W. Immunity, neuroglia and neuroinflammation in autism. Int Rev Psychiatry 2005, 17:485-495.
12. Sheikh A.M., Li X., Wen G., Tauqueer Z., Brown W.T., Malik M. Cathepsin D and apoptosis related proteins are elevated in the brain of autistic subjects. Neuroscience 2010, 165:363-370.
13. Sheikh A.M., Malik M., Wen G., et al. BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects. J Neurosci Res 2010, 88:2641-2647.
14. Araghi-Niknam M., Fatemi S.H. Levels of Bcl-2 and P53 are altered in superior frontal and cerebellar cortices of autistic subjects. Cell Mol Neurobiol 2003, 23:945-952.
15. Berilgen M.S., Mungen B., Ustundag B., Demir C. Serum ghrelin levels are enhanced in patients with epilepsy. Seizure 2006, 15:106-111.
16. Aydin S. Increased ghrelin levels in epileptic patients. Seizure 2006, 15:658.
17. Greco R., Latini G., Chiarelli F., Iannetti P., Verrotti A. Leptin, ghrelin, and adiponectin in epileptic patients treated with valproic acid. Neurology 2005, 65:1808-1809.
18. Prodam F., Bellone S., Casara G., et al. Ghrelin levels are reduced in prepubertal epileptic children under treatment with carbamazepine or valproic acid. Epilepsia 2010, 51:312-315.
19. Sierra-Paredes G., Sierra-Marcuno G. Extrasynaptic GABA and glutamate receptors in epilepsy. CNS Neurol Disord Drug Targets 2007, 6:288-300.
20. Erickson J.C., Clegg K.E., Palmiter R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 1996, 381:415-421.
21. Lin L.C., Lee W.-T., Chen I.-J., Yang R.-C. Lower plasma neuropeptide Y level in patients with atypical febrile convulsions. Kaohsiung J Med Sci 2010, 26:8-12.
22. Dube C. Neuropeptide Y: potential role in recurrent developmental seizures. Peptides 2007, 28:441-446.
23. Obay B.D., Tasdemir E., Tumer C., Bilgin H.M., Sermet A. Antiepileptic effects of ghrelin on pentylenetetrazole-induced seizures in rats. Peptides 2007, 28:1214-1219.
24. Cowley M.A., Smith R.G., Diano S., et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 2003, 37:649-661.
25. Chung H., Kim E., Lee D.H., et al. Ghrelin inhibits apoptosis in hypothalamic neuronal cells during oxygen-glucose deprivation. Endocrinology 2007, 148:148-159.
26. Lee J., Lim E., Kim Y., Li E., Park S. Ghrelin attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. J Endocrinol 2010, 205:263-270.