Effect of strontium on human Runx2+/- osteoblasts from a patient with cleidocranial dysplasia

European Journal of Pharmacology

Volumn 654, Issue 3, 2011, Pages 195-199

  Römer, Piero ^a   Behr, Michael ^a   Proff, Peter ^a   Faltermeier, Andreas ^a   Reicheneder, Claudia ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

Cleidocranial dysplasia; Hydroxyapatite; Osteoblast; Runx2; Strontium

Indexed keywords

BONE SIALOPROTEIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HYDROXYAPATITE; OSTEOCALCIN; STRONTIUM; TRANSCRIPTION FACTOR RUNX2;

ARTICLE; BONE MINERALIZATION; CELL COUNT; CELL ISOLATION; CELL PROLIFERATION; CLEIDOCRANIAL DYSPLASIA; CONTROLLED STUDY; DRUG MECHANISM; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BIOLOGICAL MARKERS; CELL COUNT; CELL LINE; CELL PROLIFERATION; CLEIDOCRANIAL DYSPLASIA; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DURAPATITE; GENE EXPRESSION REGULATION; HUMANS; OSTEOBLASTS; POLYMERASE CHAIN REACTION; STRONTIUM;

EID: 79951675079     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.12.031     Document Type: Article

References (32)

1. P. Ammann, V. Shen, B. Robin, Y. Mauras, J.P. Bonjour, and R. Rizzoli Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats J. Bone Miner. Res. 19 2004 2012 2020 (Pubitemid 41103416)
2. L.F. Bonewald, S.E. Harris, J. Rosser, M.R. Dallas, S.L. Dallas, N.P. Camacho, B. Boyan, and A. Boskey Von Kossa staining alone is not sufficient to confirm that mineralization in vitro represents bone formation Calcif. Tissue Int. 72 2003 537 547 (Pubitemid 36958554)
3. A.L. Boskey, S. Gadaleta, C. Gundberg, S.B. Doty, P. Ducy, and G. Karsenty Fourier transform infrared microspectroscopic analysis of bones of osteocalcin-deficient mice provides insight into the function of osteocalcin Bone 23 1998 187 196 (Pubitemid 28434662)
4. T.C. Brennan, M.S. Rybchyn, W. Green, S. Atwa, A.D. Conigrave, and R.S. Mason Osteoblasts play key roles in the mechanisms of action of strontium ranelate Br. J. Pharmacol. 157 2009 1291 1300
5. E. Canalis, M. Hott, P. Deloffre, Y. Tsouderos, and P.J. Marie The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro Bone 18 1996 517 523 (Pubitemid 26257871)
6. J. Caverzasio Strontium ranelate promotes osteoblastic cell replication through at least two different mechanisms Bone 42 2008 1131 1136
7. N. Chattopadhyay, S.J. Quinn, O. Kifor, C. Ye, and E.M. Brown The calcium sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation Biochem. Pharmacol. 74 2007 438 447 (Pubitemid 46970843)
8. R.A. Chen, and W.G. Goodman Role of the calcium-sensing receptor in parathyroid gland physiology Am. J. Physiol. Renal. Physiol. 286 2004 F1005 F1011
9. S. Choudhary, S. Wadhwa, L.G. Raisz, C. Alander, and C.C. Pilbeam Extracellular calcium is a potent inducer of cyclooxygenase-2 in murine osteoblasts through an ERK signaling pathway J. Bone Miner. Res. 18 2003 1813 1824 (Pubitemid 37322559)
10. M.M. Cohen Jr. Perspectives on Runx genes: an update Am. J. Med. Genet. A 149A 2009 2629 2646
11. J. Coulombe, H. Faure, B. Robin, and M. Ruat In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor Biochem. Biophys. Res. Commun. 323 2004 1184 1190 (Pubitemid 39296549)
12. O. Delannoy, D. Bazot, and P.J. Marie Long-term treatment with strontium ranelate increases vertebral bone mass without deleterious effect in mice Metabolism 51 2002 906 911 (Pubitemid 34784820)
13. D. Farlay, G. Boivin, G. Panczer, A. Lalande, and P.J. Meunier Long-term strontium ranelate administration in monkeys preserves characteristics of bone mineral crystals and degree of mineralization of bone J. Bone Miner. Res. 20 2005 1569 1578 (Pubitemid 41243546)
14. R.T. Franceschi, C. Ge, G. Xiao, H. Roca, and D. Jiang Transcriptional regulation of osteoblasts Cells Tissues Organs 189 2009 144 152
15. R.K. Garg, and P. Agrawal Clinical spectrum of cleidocranial dysplasia: a case report Cases J. 8 2008 377
16. C. Ge, G. Xiao, D. Jiang, Q. Yang, N.E. Hatch, and R.T. Franceschi Identification and functional characterization of extracellular-regulated kinase/MAPK phosphorylation sites in the Runx2 transcription factor J. Biol. Chem. 284 2009 32533 32543
17. J.A. Gordon, C.E. Tye, A.V. Sampaio, T.M. Underhill, G.K. Hunter, and H.A. Goldberg Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralisation in vitro Bone 41 2007 462 473 (Pubitemid 47199144)
18. A.S. Hurtel-Lemaire, R. Mentaverri, A. Caudrillier, F. Cournarie, A. Wattel, S. Kamel, E.F. Terwilliger, E.M. Brown, and M. Brazier The calcium sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signalling pathways J. Biol. Chem. 284 2009 575 584
19. G. Karsenty Transcriptional control of skeletogenesis Annu. Rev. Genomics Hum. Genet. 9 2008 183 196
20. T. Komori, H. Yagi, S. Nomura, A. Yamaguchi, K. Sasaki, K. Deguchi, Y. Shimizu, R.T. Bronson, Y.H. Gao, M. Inanda, M. Sato, R. Okamoto, Y. Kitamura, S. Yoshiki, and T. Kishimoto Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts Cell 30 1997 755 764 (Pubitemid 27516178)
21. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(t)) method Methods 25 2001 402 408 (Pubitemid 34164012)
22. Y. Lou, A. Javed, S. Hussai, J. Colby, D. Frederick, J. Pratap, R. Xie, T. Gaur, A.J. van Wijnen, S.N. Jones, G.S. Stein, J.B. Lian, and J.L. Stein A Runx2 threshold for the cleidocranial dysplasia phenotype Hum. Mol. Genet. 18 2009 556 568
23. S. Lymperi, N. Horwood, S. Marley, M.Y. Gordon, A.P. Cope, and F. Dazzi Strontium can increase some osteoblasts without increasing haematopoietic stem cells Blood 111 2008 1173 1181 (Pubitemid 351213398)
24. P.J. Marie, M. Hott, D. Modrowski, C. De Pollak, J. Guillemain, P. Deloffre, and Y. Tsouderos An uncoupling agent containing strontium prevents bone loss by depressing bone resorption and maintaining bone formation in estrogen-deficient rats J. Bone Miner. Res. 18 1993 607 615 (Pubitemid 23127921)
25. S. Mundlos, F. Otto, C. Mundlos, J.B. Mulliken, A.S. Aylsworth, S. Albright, D. Lindhout, W.G. Cole, W. Henn, J.H. Knoll, M.J. Owen, R. Mertelsmann, B.U. Zabel, and B.R. Olsen Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia Cell 89 1997 773 779 (Pubitemid 27516180)
26. A. Neuprez, M. Hiligsmann, S. Scholtissen, O. Bruyere, and J.Y. Reginster Strontium ranelate: the first agent of a new therapeutic class in osteoporosis Adv. Ther. 25 2008 1235 1256
27. F. Otto, A.P. Thornell, T. Crompton, A. Denzel, K.C. Gilmour, I.R. Rosewell, G.W. Stamp, R.S. Beddington, S. Mundlos, B.R. Olsen, P.B. Selby, and M.J. Owen Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development Cell 30 1997 765 771 (Pubitemid 27516179)
28. M. Shanazari, N.A. Sharkey, G.J. Fosmire, and R.M. Leach Effects of strontium on bone strength, density, volume, and microarchitecture in laying hens J. Bone Miner. Res. 21 2006 1696 1703 (Pubitemid 46141224)
29. S. Unger, E. Mornet, S. Mundlos, S. Blaser, and D.E. Cole Severe cleidocranial dysplasia can mimic hypophosphatasia Eur. J. Pediatr. 161 2002 623 626 (Pubitemid 35471819)
30. Y.H. Wang, Y. Liu, P. Maye, and D.W. Rowe Examination of mineralized nodule formation in living osteoblastic cultures using fluorescent dyes Biotechnol. Prog. 22 2006 1697 1701 (Pubitemid 44912676)
31. G. Xiao, D. Jiang, P. Thomas, M.D. Benson, K. Guan, G. Karsenty, and R.T. Franceschi MAPK pathways activate and phophorylate the osteoblast-specific transcription factor, Cbfa1 J. Biol. Chem. 275 2000 4453 4459 (Pubitemid 30094689)
32. L.L. Zhu, S. Zaidi, Y. Peng, H. Zhou, B.S. Moonga, A. Blesius, I. Dupin-Roger, M. Zaidi, and L. Sun Induction of a program gene expression during osteoblast differentiation with strontium ranelate Biochem. Biophys. Res. Commun. 355 2007 307 311 (Pubitemid 46282628)