Experimental varicocele in the rat: Early evaluation of the nitric oxide levels and histological alterations in the testicular tissue

Andrologia

Volumn 37, Issue 4, 2005, Pages 115-118

  De Stefani, Stefano ^a,b   Silingardi, V ^a   Micali, S ^a   Mofferdin, A ^a   Sighinolfi, M C ^a   Celia, A ^a   Bianchi, G ^a   Giulini, S ^a   Volpe, A ^a   Giusti, F ^a   Maiorana, A ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Antioxidant agents; Experimental varicocele; Rat germinal cells; Testicular nitric oxide

Indexed keywords

NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; GONAD; HISTOPATHOLOGY; MALE; NONHUMAN; RAT; SPERMATIC VEIN; TESTIS; VARICOCELE; VEIN DILATATION; ANIMAL; ILIAC VEIN; LIGATION; MALE INFERTILITY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; WISTAR RAT;

ANIMALS; ILIAC VEIN; INFERTILITY, MALE; LIGATION; MALE; NITRIC OXIDE; RATS; RATS, WISTAR; TESTIS; VARICOCELE;

EID: 33644683993     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/j.1439-0272.2005.00660.x     Document Type: Article

References (17)

1. Aksoy H, Aksoy Y, Ozbey I, Altuntas I, Akcay F (2000) The relationship between varicocele and semen nitric oxide concentrations. Urol Res 28:357-359.
2. Carmignani G, Tedde G, De Stefani S, Montella A, Pirozzi Farina F, Maffezzini M (1983a) Experimental varicocele in the rat - a new experimental model. I. Effect on testicular structure. Urol Res 11:195-198.
3. Carmignani G, De Stefani S, Maffezzini M, Corbu C, Pirozzi Farina F (1983b) Experimental varicocele in the rat - a new experimental model. II. Effect on impregnating ability. Urol Res 11:241-243.
4. Del Punta K, Charreau AH, Pignataro OP (1996) Nitric oxide inhibits Leydig cell steroidogenesis. Endocrinology 137:5337-5343.
5. Köksal T, Erdoǧru T, Topta B, Hakan Gülkesen K, Usta M, Baykal A, Baykara M (2002) Effect of experimental varicocele in rats on testicular oxidative stress status. Andrologia 34:242-244.
6. Koltuksuz U, Irmak MK, Karaman A, Uz E, Var A, Ozyurt H, Akyol O (2000) Testicular nitric oxide levels after unilateral testicular torsion/detorsion in rats pretreated with caffeic acid phenethyl ester. Urol Res 28:360-363.
7. Middendorf R, Muller D, Wichers S, Holstein AF, Davidoff MS (1997) Evidence for production and functional activity of nytric oxide in seminiferous tubules and blood vessels of the human testis. J Clin Endocrinol Metab 82:4154-4161.
8. Ozbek E, Turkoz Y, Gokdeniz R, Davarci M, Ozugurlu F (2000) Increased nitric oxide production in the spermatic vein of patients with varicocele. Eur Urol 37:172-175.
9. Redmon JB, Carey P, Pryor JL (2002) Varicocele: the most common cause of male factor infertility? Hum Reprod Update 8:53-58.
10. Romeo C, Ientile R, Impellizzeri P, Turiaco N, Teletta M, Antonuccio P, Basile M, Gentile C (2003) Preliminary report on nitric oxide-mediated oxidative damage in adolescent varicocele. Hum Reprod 18:26-29.
11. Rosselli M, Dubey R, Imthurn B, Macas E, Keller PJ (1995) Effect of nitric oxide on human spermatozoa: evidence that nitric oxide decreases sperm motility and induces sperm toxicity. Hum Reprod 10:1786-1790.
12. Rosselli M, Keller PJ, Dubej RK (1998) Role of nitric oxide in the biology, physiology and pathophysiology of reproduction. Hum Reprod Update 4:3-24.
13. Santoro G, Romeo C, Impellizzeri P, Ientile R, Cutroneo G, Trimarchi F, Pedale S, Turiaco N, Gentile C (2001) Nitric oxide synthase patterns in normal and varicocele testis in adolescents. BJU Int 88:967-973.
14. Semercioz A, Onur R, Ogras S, Orhan I (2003) Effects of melatonin on testicular tissue oxide level and antioxidant enzyme activities in experimentally induced left varicocele. Neuroendocrinol Lett 24:86-90.
15. Turner TT (2001) The study of varicocele through the use of animal models. Hum Reprod Update 7:78-84.
16. Turner TT, Howards SS (1994) The venous anatomy of experimental left varicocele: comparison with naturally occurring left varicocele in the human. Fertil Steril 62:869-875.
17. Zini A, O'Bryan MK, Magid MS, Schlegel PN (1996) Immunohistochemical localization of endothelial nitric oxide synthase in human testis, epididymis, and vas deferens suggests a possible role for nitric oxide in spermatogenesis, sperm maturation, and programmed cell death. Biol Reprod 55:935-941.