Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest

Cell Host and Microbe

Volumn 9, Issue 2, 2011, Pages 103-114

  Reitsma, Justin M ^a   Savaryn, John Paul ^a   Faust, Katherine ^a   Sato, Hiromi ^a   Halligan, Brian D ^a   Terhune, Scott S ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; BENZIMIDAVIR; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1; PROTEASOME; PROTEIN PUL97; PROTEIN TIP60; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ANTIVIRAL SUSCEPTIBILITY; ARTICLE; CELL CYCLE ARREST; CELL NUCLEUS; DRUG TARGETING; ENZYME DEGRADATION; ENZYME INHIBITION; FIBROBLAST; FUNCTIONAL PROTEOMICS; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; VIRUS REPLICATION; VIRUS STRAIN;

ANTIVIRAL AGENTS; BENZIMIDAZOLES; CELL CYCLE; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DOWN-REGULATION; HISTONE ACETYLTRANSFERASES; HUMANS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BINDING; PROTEIN KINASE INHIBITORS; RIBONUCLEOSIDES;

HERPESVIRIDAE; HUMAN HERPESVIRUS 5;

EID: 79951592516     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2011.01.006     Document Type: Article

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