Degradation of p21cip1 in cells productively infected with human cytomegalovirus

Journal of Virology

Volumn 75, Issue 8, 2001, Pages 3613-3625

  Chen, Z ^a   Knutson, E ^a   Kurosky, A ^a   Albrecht, T ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALOXISTATIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CALPAIN; CALPASTATIN; CYCLIN DEPENDENT KINASE; CYCLIN E; PHOSPHOLIPID; PROTEIN P21; PROTEIN P27; RNA; BENZYLOXYCARBONYLLEUCYL LEUCYL LEUCINE ALDEHYDE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CALCIUM BINDING PROTEIN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; CYSTEINE PROTEINASE; DRUG DERIVATIVE; LEUCINE; LEUPEPTIN; MESSENGER RNA; MULTIENZYME COMPLEX; PROTEASOME; UBIQUITIN;

ARTICLE; CALCIUM CELL LEVEL; CATALYSIS; CELL CYCLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; ENZYME ACTIVATION; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN DEGRADATION; VIRUS REPLICATION; WESTERN BLOTTING; CELL LINE; CHEMISTRY; CYTOMEGALOVIRUS; DOSE RESPONSE; DRUG ANTAGONISM; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN MOTIF; TIME;

AMINO ACID MOTIFS; CALCIUM-BINDING PROTEINS; CALPAIN; CELL CYCLE; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; CYSTEINE ENDOPEPTIDASES; CYTOMEGALOVIRUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HUMANS; LEUCINE; LEUPEPTINS; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; RNA, MESSENGER; TIME FACTORS; UBIQUITINS;

EID: 0034745182     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.8.3613-3625.2001     Document Type: Article

References (92)

1. 3H]-arachidonic acid prelabeled cells
2. Human cytomegalovirus stimulates arachidonic acid metabolism through pathways that are affected by inhibitors of phospholipase A2 and protein kinase C
3. Heterogeneous morphologic features of plaques induced by five strains of human cytomegalovirus
4. Receptor-initiated activation of cells and their oncogenes by herpes-family viruses
5. Cell-activation responses to cytomegalovirus infection: Relationship to the phasing of CMV replication and to the induction of cellular damage
6. Cytomegalovirus: Development and progression of cytopathic effects in human cell culture
7. Induction of cellular DNA synthesis and increased mitotic activity in Syrian hamster embryo cells abortively infected with human cytomegalovirus
8. Congenital and perinatal cytomegalovirus infections
9. A cascade of degradative hydrolase activity contributes to hepatocyte necrosis during anoxia
10. WAF1/CIP1 expression
11. Activation of proto-oncogenes: An immediate early event in human cytomegalovirus infection
12. Transcriptional activation of cellular oncogenes fos, jun, and myc by human cytomegalovirus
13. Cellular oncogene activation by human cytomegalovirus: Lack of correlation with virus infectivity and IE gene expression
14. Increased activity of DNA-binding proteins in nuclei of human cytomegalovirus-infected MRC-5 cells
15. 1 checkpoint function
16. Multiple ribosomal RNA cleavage pathways in mammalian cells
17. The cyclin E promoter is activated by human cytomegalovirus 86-kDa immediate early protein
18. Inhibition of cellular Cdk2 activity blocks human cytomegalovirus replication
19. Human cytomegalovirus inhibits cellular DNA synthesis and arrests productively infected cells in late GI
20. Human cytomegalovirus infection results in altered Cdk2 subcellular localization
21. Calpain: A protease in search of a function?
22. PEST motifs are not required for rapid calpain-mediated proteolysis of c-fos protein
23. Role of human cytomegalovirus immediate-early proteins in cell growth control
24. Waf1/cip1 with PCNA
25. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples
26. The ubiquitin-proteasome proteolytic pathway
27. 2+ requirement for autolysis
28. Calcium-activated neutral protease (calpain) system: Structure, function, and regulation
29. Summary of the 2nd International Symposium on Cytomegalovirus
30. 1/S transition
31. Mammalian GI cyclins
32. Purification and analysis of CIP/KIP proteins
33. WAFI, a potential mediator of p53 tumor suppression
34. Cdk inhibitors: On the threshold of checkpoints and development
35. The role of protein stability in the cell cycle and cancer
36. Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase δ holoenzyme
37. Identification of domains within the human cytomegalovirus major immediate-early 86-kilodalton protein and the retinoblastoma protein required for physical and functional interaction with each other
38. DNA damage induces p21 protein expression by inhibiting ubiquitination in ML-1 cells
39. Cip1/Waf1 by caspases is an early event during DNA damage-induced apoptosis
40. Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein
41. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
42. Inhibition of cyclin-dependent kinases by p21
43. Degradation of transcription factors, c-Jun and c-Fos, by calpain
44. Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
45. Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest
46. Epidermal growth factor increases the level of cyclin-dependent kinase (CDK) inhibitor p21/CIP1(CDK-interacting protein 1) in A431 cells by increasing the half-lives of the p21/CIP1 transcript and the p21/CIP1 protein
47. Domain mapping of the human cytomegalovirus IE1-72 and cellular p107 protein-protein interaction and the possible functional consequences
48. Cip1
49. The role of cyclin E in cell proliferation, development and cancer
50. Proteolytic cleavage of human p53 by calpain: A potential regulator of protein stability
51. Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair
52. 1 to S
53. Purification and crystallization of cyclin-dependent kinase inhibitor p21
54. 1 phase
55. The human cytomegalovirus IE86 protein can block cell cycle progression after inducing transition into the S phase of permissive cells
56. The ubiquitin-proteasome system and cellular proliferation and regulation in osteoblastic cells
57. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
58. 2+ responses in cytomegalovirus-infected fibroblasts of human origin
59. Control of gene expression by proteolysis
60. Inhibition of nucleotide excision repair by the cyclin-dependent kinase inhibitor p21
61. Resistance to antivirals in human cytomegalovirus: Mechanisms and clinical significance
62. Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21
63. The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter
64. PEST sequences and regulation by proteolysis
65. 1/S phase transition by expression of cyclins D1 and E with an inducible system
66. Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis
67. Calpain activity increases in hepatocytes following addition of ATP. Demonstration of a novel fluorescent approach
68. Impact of cytomegalovirus infection on organ transplant recipients
69. The structure-function relationship between peptide aldehyde derivatives on initiation of neurite outgrowth in PC12h cells
70. The role of calcium in the cell cycle: Facts and hypotheses
71. Calcium, protease action, and the regulation of the cell cycle
72. Cytomegalovirus in the setting of infection with human immunodeficiency virus
73. 1 cyclins
74. G1 phase progression: Cycling on cue
75. Inhibitors of mammalian G1 cyclin-dependent kinases
76. 1 into early S phase in terminally differentiated cells
77. Interaction of human cytomegalovirus with p53: Possible role in coronary, restenosis
78. A novel aspect of calpain activation
79. In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64
80. Human cytomegalovirus immediate-early protein IE2 tethers a transcriptional repression domain to p53
81. Hydrolysis of inositol lipids: An early signal of human cytomegalovirus infection
82. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
83. 1
84. p21 is a universal inhibitor of cyclin kinases
85. C1P1/WAF1 and cyclin D proteins
86. p21-containing cyclin kinases exist in both active and inactive states
87. Calpain subunits remain associated during catalysis
88. The major calpain isozymes are long-lived proteins. Design of an antisense strategy for calpain depletion in cultured cells
89. pH dependency of mu-calpain and m-calpain activity assayed by casein zymography following traumatic brain injury in the rat
90. Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: A casein zymography study
91. Cellular gene expression altered by human cytomegalovirus: Global monitoring with oligonucleotide arrays
92. Secretagogue-induced proteolysis of cAMP-dependent protein kinase in intact rat alveolar epithelial type II cells