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Volumn 105, Issue 4, 2011, Pages 509-517

Rational design, synthesis and evaluation of first generation inhibitors of the Giardia lamblia fructose-1,6-biphosphate aldolase

(14) Li, Zhimin a Liu, Zhengang a Cho, Dae Won a Zou, Jiwen a Gong, Maozhen a Breece, Robert M b Galkin, Andrey c Li, Ling a Zhao, Hong a Maestas, Gabriel D a Tierney, David L b Herzberg, Osnat c Dunaway Mariano, Debra a Mariano, Patrick S a

a UNIVERSITY OF NEW MEXICO (United States)

b MIAMI UNIVERSITY (United States)

c UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE (United States)

Author keywords

EXAFS; Fructose 1,6 biphosphate aldolase; Giardia lamblia; Hydroxypyridinone; Inhibitor design; Zn2+ coordination

Indexed keywords

3 HYDROXY 2 PYRIDONE INHIBITOR; DIPYRONE; ENZYME INHIBITOR; FRUCTOSE 1,6 BISPHOSHATE ALDOLASE; FRUCTOSE 1,6 BISPHOSHATE ALDOLASE INHIBITOR; FRUCTOSE BISPHOSPHATE ALDOLASE; HISTIDINE; UNCLASSIFIED DRUG; ZINC;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL REACTION KINETICS; COMPUTER MODEL; CRYSTAL STRUCTURE; DRUG BINDING; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; GIARDIA LAMBLIA; HYDROGEN BOND; MOLECULAR INTERACTION; X RAY ABSORPTION SPECTROSCOPY;

ANIMALS; BINDING SITES; DIHYDROXYACETONE PHOSPHATE; ENZYME INHIBITORS; FRUCTOSE-BISPHOSPHATE ALDOLASE; GIARDIA LAMBLIA; KINETICS; LIGANDS; ZINC;

GIARDIA INTESTINALIS;

EID: 79951584886 PISSN: 01620134 EISSN: None Source Type: Journal
DOI: 10.1016/j.jinorgbio.2010.12.012 Document Type: Article

Times cited : (24)

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