The protective effects and potential mechanism of Calpain inhibitor Calpeptin against focal cerebral ischemia-reperfusion injury in rats

Molecular Biology Reports

Volumn 38, Issue 2, 2011, Pages 905-912

  Peng, Sheng ^a   Kuang, Zhongshen ^a,b   Zhang, Yan ^a   Xu, Hang ^b   Cheng, Qinghong ^b  

^a SOOCHOW UNIVERSITY   (China)

^b SHIHEZI UNIVERSITY   (China)

Author keywords

Apoptosis; Calpain; Calpeptin; Caspase 3; Infarction volume; Ischemia reperfusion injury; Neurological functions

Indexed keywords

CALPEPTIN; CASPASE 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; BRAIN NERVE CELL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; HIPPOCAMPAL CA1 REGION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC EXAMINATION; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY;

ANIMALS; APOPTOSIS; BRAIN ISCHEMIA; CASPASE 3; CEREBRAL INFARCTION; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; TETRAZOLIUM SALTS;

ANIMALIA; RATTUS;

EID: 79951579865     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-010-0183-2     Document Type: Article

References (28)

1. BH Juurlink MI Sweeney 1997 Mechanisms that result in damage during and following cerebral ischemia Neurosci Biobehav Rev 21 121 128 1:STN:280:DyaK2s3hs1Oltw%3D%3D 10.1016/S0149-7634(96)00001-2 9062934 (Pubitemid 27102557)
2. Fang NX, Yao YT, Shi CX, Li LH (2010) Attenuation of ischemia-reperfusion injury by sevoflurane postconditioning involves protein kinase B and glycogen synthase kinase 3 beta activation in isolated rat hearts. Mol Biol Rep. 2010 Mar 10. [Epub ahead of print] PubMed PMID: 20217242
3. Miao Y, Qiu Y, Lin Y, Miao Z, Zhang J, Lu X (2010) Protection by pyruvate against glutamate neurotoxicity is mediated by astrocytes through a glutathione-dependent mechanism. Mol Biol Rep. 2010 Feb 24. [Epub ahead of print] PubMed PMID:20182801
4. Yang J, Zhang XD, Yang J, Ding JW, Liu ZQ, Li SG, Yang R (2010) The cardioprotective effect of fluvastatin on ischemic injury via down-regulation of toll-like receptor 4. Mol Biol Rep. 2010 Feb 4. [Epub ahead of print] PubMed PMID:20127518
5. Yao YT, Li LH, Chen L, Wang WP, Li LB, Gao CQ (2009) Sevoflurane postconditioning protects isolated rat hearts against ischemia-reperfusion injury: the role of radical oxygen species, extracellular signal-related kinases 1/2 and mitochondrial permeability transition pore. Mol Biol Rep. 2009 Aug 20. [Epub ahead of print] PubMed PMID: 19693689
6. Yilmaz E, Akar R, Eker ST, Deda G, Adiguzel Y, Akar N (2010) Relationship between functional promoter polymorphism in the XBP1 gene (-116C/G) and atherosclerosis, ischemic stroke and hyperhomocysteinemia. Mol Biol Rep. 2010 Jan;37(1):269-272. Epub 2009 Aug 11. PubMed PMID: 19669932
7. Hou X, Wu X, Ma J, Lv X, Jin X (2010) Erythropoietin augments the efficacy of therapeutic angiogenesis induced by allogenic bone marrow stromal cells in a rat model of limb ischemia. Mol Biol Rep. 2010 Mar;37(3):1467-1475. Epub 2009 May 12. PubMed PMID: 19434514
8. Wan J, Xiong C, Zheng F, Zhou X, Huang C, Jiang H (2008) Study of Kir6.2/KCNJ11 gene in a sudden cardiac death pedigree. Mol Biol Rep. 2008 Jun;35(2):119-123. Epub 2007 Mar 13. PubMed PMID: 17431820 (Pubitemid 351713239)
9. RT Bartus RL Dean S Mennerick, et al. 1998 Temporal ordering of Pathogenic events following transient global ischemia Brain Res 790 1 13 1:CAS:528:DyaK1cXjtVGrsr4%3D 10.1016/S0006-8993(97)01414-5 9593800 (Pubitemid 28234482)
10. H Yamakawa Y Banno S Nakashima, et al. 2001 Crucial role of calpain in hypoxic PC12 cell death: calpain, but not caspases, mediates degradation of cytoskeletal proteins and protein kinase C-alpha and -delta Neurol Res 23 522 530 1:CAS:528:DC%2BD3MXlslWht7c%3D 10.1179/016164101101198776 11474809 (Pubitemid 32642786)
11. H-Y Wu EY Yuen Y-F Lu, et al. 2005 Regulation of N-Methyl-D-aspartate receptors by calpain in cortical neurons J Biol Chem 280 21588 21593 1:CAS:528:DC%2BD2MXks1elt7Y%3D 10.1074/jbc.M501603200 15790561 (Pubitemid 40805726)
12. B Junoy H Maccario JL Mas, et al. 2002 Proteasome implication in phorbol ester- and GnRH-induced selective down-regulation of PKC (alpha, epsilon, zeta) in alpha T(3)-1 and L beta T(2) gonadotrope cell lines Endocrinology 143 1386 1403 1:CAS:528:DC%2BD38XisFGisLg%3D 10.1210/en.143.4.1386 11897696 (Pubitemid 34274369)
13. Yamashima T, Tonchev AB, Tsukada T, et al (2003) Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates. HIPPOCAMPUS 13:791-800 (Pubitemid 37407965)
14. 2-induced apoptosis of hepatocytes Int J Mol Med 11 369 374 1:CAS:528:DC%2BD3sXhslKqtLo%3D 12579342
15. M Takaoka M Itoh S Kohyama, et al. 2000 Proteasome inhibition attenuates renal endothelin-1 production and the development of ischemic acute renal failure in rats J Cardiovasc Pharmacol 36 S225 S227 1:CAS:528: DC%2BD3cXnslKju7w%3D 11078383
16. J Feng BJ Schaus JA Fallavollita, et al. 2001 Preload induces troponin I degradation independently of myocardial ischemia Circulation 103 2035 2037 1:CAS:528:DC%2BD3MXjvVarsb8%3D 11319190 (Pubitemid 32373003)
17. A Das EA Sribnick JM Wingrave, et al. 2005 Calpain activation in apoptosis of ventral spinal cord 4.1 (VSC4.1) motoneurons exposed to glutamate: calpain inhibition provides functional neuroprotection J Neurosci Res 81 551 562 1:CAS:528:DC%2BD2MXnsVCjtLc%3D 10.1002/jnr.20581 15968645 (Pubitemid 41297392)
18. E Zea Longa PR Weinstein S Carlson R Cummins 1989 Reversible middle cerebral artery occlusion without craniectomy in rats Stroke 20 84 91 (Pubitemid 19040218)
19. L Belayev OF Alonso R Busto, et al. 1996 Middle cerebral artery occlusion in the rat by intraluminal suture: neurological and pathological evaluation of an improved model Stroke 27 1616 1623 1:STN:280:DyaK28znvVGktw%3D%3D 8784138 (Pubitemid 26295914)
20. JB Bederson LH Pitts M Tsuj, et al. 1986 Rat middle cerebral artery occlusion evaluation of the model and development of a neurologic evaluation Stroke 17 472 476 1:STN:280:DyaL283js1Gktw%3D%3D 3715945 (Pubitemid 16085691)
21. JM Lee GJ Zipfel DW Choi 1999 The changing landscape of ischemic brain injury mechanism Nature 399 A7 A14 1:CAS:528:DyaK1MXktlejsrY%3D 10392575
22. T Yamashima Y Kohda K Tsuchiya T Ueno J Yamashita, et al. 1998 Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on "calpain-cathepsin hypothesis" Eur J Neurosci 10 1723 1733 1:STN:280:DyaK1cvitFOltg%3D%3D 10.1046/j.1460-9568.1998.00184.x 9751144 (Pubitemid 28327319)
23. CG Markgraf NL Velayo MP Johnson, et al. 1998 Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats Stroke 29 152 158 1:CAS:528:DyaK1cXntVKqsQ%3D%3D 9445345 (Pubitemid 28046958)
24. M Higuchi M Tomioka J Takano, et al. 2005 Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice over expressing their specific inhibitors J Biol Chem 280 15229 15237 1:CAS:528:DC%2BD2MXjtFSlt70%3D 10.1074/jbc.M500939200 15699033 (Pubitemid 40562879)
25. K Blomgren C Zhu X Wang JO Karlsson AL Leverin, et al. 2001 Synergisti activation of caspase-3 by m-calpain after neonatal hypoxia-ischemia: a mechanism of "pathological apoptosis" J Biol Chem 276 10191 10198 1:CAS:528:DC%2BD3MXis1Oktrs%3D 10.1074/jbc.M007807200 11124942
26. A Rami R Agarwal G Botez, et al. 2000 mu-Calpain activation, DNA fragmentation, and synergistic effects of caspase and calpain inhibitors in protecting hippocampal neurons from ischemic damage Brain Res 866 299 312 1:CAS:528:DC%2BD3cXjsVGisbw%3D 10.1016/S0006-8993(00)02301-5 10825507 (Pubitemid 30313034)
27. G Gao QP Dou 2000 N-terminal cleavage of bax by calpain generates apotent proapoptotic 18-kDa fragment that promotea bcl-2-independent cytochrome C release and apoptotic cell death J Cell Biochem 80 53 72 1:CAS:528: DC%2BD3cXot1Glsrw%3D 10.1002/1097-4644(20010101)80:1<53::AID-JCB60>3.0. CO;2-E 11029754
28. T Nitatori N Sato S Waguri Y Karasawa H Araki K Shibanai E Komimani Y Uchiyama 1995 Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis J Neurosci 15 1001 1011 1:CAS:528:DyaK2MXjvVCgtrk%3D 7869078