Proteasome inhibition attenuates renal endothelin-1 production and the development of ischemic acute renal failure in rats

Journal of Cardiovascular Pharmacology

Volumn 36, Issue 5 SUPPL. 1, 2000, Pages

  Takaoka, M ^a   Itoh, M ^a   Kohyama, S ^a   Shibata, A ^a   Ohkita, M ^a   Matsumura, Y ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Acute renal failure; Endothelin (ET); Ischemia; Proteasome

Indexed keywords

CALPASTATIN; CALPEPTIN; DYE; ENDOTHELIN 1; PROTEASOME; PROTEASOME INHIBITOR;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; KIDNEY FUNCTION; KIDNEY ISCHEMIA; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; RAT;

EID: 0033734939     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200036001-00039     Document Type: Article

References (10)

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4. Pathophysiological role of endothelin in acute renal failure
5. Organ distribution of the three rat endothelin messenger RNAs and the effects of ischemia on renal gene expression
6. Conversion of porcine big endothelin to endothelin by an extract from the porcine aortic endothelial cells
7. A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces accumulation of ubiquitin-protein conjugates in a neuronal cell
8. Protective effect of a selective endothelin receptor antagonist, BQ-123, in ischemic acute renal failure in rats
9. Reversal of postischemic acute renal failure with a selective endothelin(A) receptor antagonist in the rat
10. Improvement of postischemic acute renal failure with the novel orally active endothelin-A receptor antagonist LU 135252 in the rat