Utilization of glycerol as cysteine and carbon sources for cephalosporin C production by Acremonium chrysogenum M35 in methionine-unsupplemented culture

Journal of Biotechnology

Volumn 151, Issue 4, 2011, Pages 363-368

  Shin, Hyun Yong ^a   Lee, Jin Young ^a   Park, Chulhwan ^b   Kim, Seung Wook ^a  

^a Korea University   (South Korea)

^b Kwangwoon University   (South Korea)

Author keywords

Acremonium chrysogenum; Cephalosporin C; Cysteine; Methionine

Indexed keywords

ACREMONIUM; CARBON SOURCE; CEPHALOSPORIN C; CYSTEINE; D-VALINE; EXPONENTIAL PHASE; METHIONINE; SYNTHASES; UP-REGULATION;

GLYCEROL;

AMINO ACIDS;

2 METHYLACYL COENZYME A RACEMASE; AMINOADIPIC ACID; BETA TUBULIN; CARBON; CEPHALOSPORIN C; CYSTEINE; GLYCEROL; ISOPENICILLIN N; METHIONINE; VALINE;

AMINO ACID SYNTHESIS; ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CARBON SOURCE; CEPHALOSPORIUM ACREMONIUM; CONTROLLED STUDY; ENZYME INDUCTION; FUNGUS CULTURE; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL;

ACREMONIUM; AMINO ACID ISOMERASES; BACTERIAL PROTEINS; CARBON; CEPHALOSPORINS; CULTURE MEDIA; CYSTEINE; GLYCEROL; METHIONINE; PEPTIDE SYNTHASES; UP-REGULATION;

ACREMONIUM CHRYSOGENUM;

EID: 79951556560     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2010.12.021     Document Type: Article

References (33)

1. Araki K., Ozeki T. Amino acid. Kirk-Othmer Encycl. Chem. Technol. 1991, 9:504-571.
2. Behmer C.J., Demain A.L. Further studies on carbon catabolite regulation of β-lactam antibiotic synthesis in Cephalosporium acremonium. Curr. Microbiol. 1983, 8:107-114.
3. Bradford M.M. Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
4. Demain A.L., Wolfe S. Biosynthesis of cephalosporins. Dev. Ind. Microbiol. 1987, 27:175-182.
5. Döbeli H., Nüesch J. Regulatory properties of O-acetyl-l-serine sulfhydrylase of Cephalosporium acremonium: evidence of an isoenzyme and its importance in cephalosporin C biosynthesis. Antimicrob. Agents Chemother. 1980, 18:111-117.
6. Gaitonde M.K. A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids. Biochem. J. 1967, 104:627-633.
7. Geiger, F., Halsberghe, B., Basselbach, H.J., Hentchel, K., Humacher, K., Korfer, M., Mannsfeld, S.P., Tanner, H., Thessen, F., Vanrobacys, J., Willigerodot, K., 1998. Process for the preparation of d,l-methionine or the salt thereof. US patent No. 5, 770-769.
8. Gutierrez S., Diez B., Montenegro E., Martin J.F. Characterization of the Cephalosporium acremonium pcbAB gene encoding alpha-aminoadipyl-cysteinyl-valine synthetase, a large multidomain peptide synthetase: linkage to the pcbC gene as a cluster of early cephalosporin biosynthetic genes and evidence of multiple functional domains. J. Bacteriol. 1991, 173:2354-2365.
9. Habe H., Morita T., Sakaki K., Kitamoto Isolation and characterization of thermo-tolerant fungi producing lignoceric acid from glycerol. J Oleo Sci. 2008, 57:251-255.
10. Hoff B., Schmitt E.K., Kück U. CPCR1, but not its interacting transcription factor AcFKH1, controls fungal arthrospore formation in Acremonium chrysogenum. Mol. Microbiol. 2005, 56:1220-1233.
11. Kamp M., Driessen A.J., Konings W.N. Compartmentalization and transport in beta-lactam antibiotic biosynthesis by filamentous fungi. Antonie Van Leeuwenhoek 1999, 75:41-78.
12. Kennedy J., Turner G. δ-(l-alpha-aminoadipyl)-l-cysteinyl-d-valine synthetase is a rate limiting enzyme for penicillin production in Aspergillus nidulans. Mol. Gen. Genet. 1996, 253:189-197.
13. Kim J.C., Kang S.W., Lim J.S., Song Y.S., Kim S.W. Stimulation of cephalosporin C production by Acremonium chrysogenum M35 with fatty acid. J. Microbiol. Biotechnol. 2006, 16:1120-1124.
14. Kosalkova K., Marcos A.T., Martin J.F. A moderate amplification of the mecB gene encoding cystathionine-gamma-lyase stimulates cephalosporin biosynthesis in Acremonium chrysogenum. J. Ind. Microbiol. Biotechnol. 2001, 27:252-258.
15. Lee M.S., Lim J.S., Kim C.H., Oh K.K., Yang D.R., Kim S.W. Enhancement of cephalosporin C production by cultivation of Cephalosporium acremonium M25 using a mixture of inocula. Lett. Appl. Microbiol. 2001, 32:402-406.
16. Liepins J., Kuorelahti S., Penttila M., Richard P. Enzymes for the NADPH-dependent reduction of dihydroxyacetone and d-glyceraldehyde and l-glyceraldehyde in the mould Hypocrea jecorina. FEBS J. 2006, 273:4229-4235.
17. Liu G., Casqueiro J., Banuelos O., Cardoza R.E., Gutierrez S., Martin J.F. Targeted inactivation of the mecB gene, encoding cystathionine-gamma-lyase, shows that the reverse transsulfuration pathway is required for high-level cephalosporin biosynthesis in Acremonium chrysogenum C10 but not for methionine induction of the cephalosporin genes. J. Bacteriol. 2001, 183:1765-1772.
18. Lounes A., Lebrihi A., Benslimane C., Lefebvre G., Germain P. Glycerol effect on spiramycine production and valine catabolism in Streptomyces ambofaciens. Curr. Microbiol. 1995, 31:304-311.
19. Martin J.F., Demain A.L. Unraveling the methionine-cephalosporin puzzle in Acremonium chrysogenum. Trends Biotechnol. 2002, 20:502-507.
20. Mehta R.J., Speth J.L., Nash C.H. Lysine stimulation of cephalosporin C synthesis. Eur. J. Appl. Microbiol. Biotechnol. 1979, 8:177-182.
21. Nüesch J., Heim J., Treichler H.-J. The biosynthesis of sulfur containing β-lactam antibiotics. Annu. Rev. Microbiol. 1987, 41:51-57.
22. Paszewski A., Natorff R., Piotrowska M., Brzywczy J., Sienko M., Grynberg M., Pizzinini E., Turner G. Regulation of Sulfur Amino Acid Biosynthesis in Aspergillus nidulans: Physiological and Genetical Aspects 2000, Paul Haupt, Bern, Switzerland.
23. Revin V.V., Kasatkin S.A., Cherkasova G.N., Nikolaev V.T., Iamashkina N.S., Chabushkina M.N., Popova O.A., Belianina V.F. Effect of the quality of fat substrate on the dynamics of fatty acid utilization during biosynthesis of cephalosporin C. Antibiot. Khimioter. 1991, 36:5-8.
24. Sambrook J., Russell D.W. Molecular Cloning. A Laboratory Manual 2001, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York. third ed.
25. Sandor E., Szentirmai A., Paul G.C., Thomas C.R., Pocsi I., Karaffa L. Analysis of the relationship between growth, cephalosporin C production, and fragmentation in Acremonium chrysogenum. Can. J. Microbiol. 2001, 47:801-806.
26. Shin H.Y., Lee J.Y., Jung Y.R., Kim S.W. Stimulation of cephalosporin C production in Acremonium chrysogenum M35 by glycerol. Bioresour. Technol. 2010, 101:4549-4553.
27. Tollnick C., Seidel G., Beyer M., Schugerl K. Investigations of the production of cephalosporin C by Acremonium chrysogenum. Adv. Biochem. Eng. Biotechnol. 2004, 86:1-45.
28. Ullan R.V., Casqueiro J., Banuelos O., Fernandez F.J., Gutierrez S., Martin J.F. A novel epimerization system in fungal secondary metabolism involved in the conversion of isopenicillin N into penicillin N in Acremonium chrysogenum. J. Biol. Chem. 2002, 277:46216-46225.
29. Ullan R.V., Casqueiro J., Naranjo L., Vaca I., Martin J.F. Expression of cefD2 and the conversion of isopenicillin N into penicillin N by the two-component epimerase system are rate-limiting steps in cephalosporin biosynthesis. Mol. Genet. Genomics 2004, 272:562-570.
30. Usher J.J., Hughes D.W., Lewis M.A., Chiang S.J. Determination of the rate-limiting step(s) in the biosynthetic pathways leading to penicillin and cephalosporin. J. Ind. Microbiol. 1992, 10:157-163.
31. Velasco J., Gutierrez S., Fernandez F.J., Marcos A.T., Arenos C., Martin J.F. Exogenous methionine increases levels of mRNAs transcribed from pcbAB, pcbC, and cefEF genes, encoding enzymes of the cephalosporin biosynthetic pathway, in Acremonium chrysogenum. J. Bacteriol. 1994, 176:985-991.
32. Warren S.C., Newton G.G.F., Abraham E.P. The role of valine in the biosynthesis of penicillin N and cephalosporin C by a Cephalosporium sp. Biochem. J. 1967, 103:902-912.
33. Zhou W., Holzhauer-Rieger K., Dors M., Schügerl K. Influence of medium composition on the cephalosporin C production with a highly productive strain Cephalosporium acremonium. J. Biotechnol. 1992, 23:315-329.