Prolyl isomerase Pin1 protects mice from endotoxin shock

PLoS ONE

Volumn 6, Issue 2, 2011, Pages

  Akiyama, Hirotada ^a   Misawa, Takuma ^a   Ono, Masao ^b   Uchida, Chiyoko ^a   Uchida, Takafumi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTOXIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; PEPTIDYLPROLYL ISOMERASE PIN1; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR PU 1; TUMOR NECROSIS FACTOR ALPHA; NIMA INTERACTING PEPTIDYLPROLYL ISOMERASE; NIMA-INTERACTING PEPTIDYLPROLYL ISOMERASE; ONCOPROTEIN; PEPTIDYLPROLYL ISOMERASE; PROTO ONCOGENE PROTEIN SPI 1; PROTO-ONCOGENE PROTEIN SPI-1; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; INNATE IMMUNITY; MORTALITY; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PNEUMONIA; PROTEIN BINDING; SHOCK; SURVIVAL RATE; TRANSCRIPTION INITIATION; ANIMAL; BACTERIAL INFECTION; CELL CULTURE; CELL STRAIN COS1; CERCOPITHECUS; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; GENETICS; INFLAMMATION; METABOLISM; MOUSE MUTANT; MULTIPLE ORGAN FAILURE; PHYSIOLOGY; SEPTIC SHOCK;

MUS;

ANIMALS; BACTERIAL INFECTIONS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTOXINS; INFLAMMATION; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; MICE, KNOCKOUT; MULTIPLE ORGAN FAILURE; PEPTIDYLPROLYL ISOMERASE; PROTO-ONCOGENE PROTEINS; SHOCK, SEPTIC; TRANS-ACTIVATORS;

EID: 79951539518     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014656     Document Type: Article

References (18)

1. Takahashi K, Uchida C, Shin RW, Shimazaki K, Uchida T, (2008) Prolyl isomerase Pin1: New findings on post-translational modifications and physiological substrates in cancer, Alzheimer's disease and asthma. Cell and Mol Life Sci 65: 359-375.
2. Liu W, Youn HD, Zhou XZ, Lu KP, Liu JO, (2001) Binding and regulation of the transcription factor NFAT by the peptidyl prolyl cis-trans isomerase Pin1. FEBS Letters 496: 105-108.
3. Lufei C, Koh TH, Uchida T, Cao X, (2007) Pin1 is required for the Ser727 phosphorylation-dependent Stat3 activity. Oncogene 26: 7656-7664.
4. Atkinson GP, Nozell SE, Harrison DK, Stonecypher MS, Chen D, et al. (2009) The prolyl isomerase Pin1 regulates the NF-kappaB signaling pathway and interleukin-8 expression in glioblastoma. Oncogene 28: 3735-3745.
5. Akira S, Uematsu S, Takeuchi O, (2006) Pathogen recognition and innate immunity. Cell 124: 783-801.
6. Poltorak A, He X, Smirnova I, Liu MY, Huffel CV, et al. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutation in Tlr4 Gene. Science 28: 2085-2088.
7. Parrillo JE, (1993) Pathogenetic mechanisms of septic shock. N Engl J Med 328: 1471-1478.
8. Liu T, Huang Y, Likhotvorik RI, Keshvara L, Hoyt DG, (2008) Protein Nerve in Mitosis Gene A Interacting-1 (Pin1) regulates degradation of inducible nitric oxide synthase in endothelial cells. Am J Physiol Cell Physiol 295: 819-827.
9. Liu T, Schneider RA, Shah V, Huang Y, Likhotvorik RI, et al. (2009) Protein Nerve in Mitosis Gene A Interacting-1 (Pin1) regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells. J Inflamm 6: 20.
10. Fujimori F, Takahashi K, Uchida C, Uchida T, (1999) Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G(0) arrest. Biochem Biophys Res Commun 265: 658-663.
11. Schletter J, Heine H, Ulmer AJ, Rietschel ET, (1995) Molecular mechanisms of endotoxin activity. Arch Microbiol 164: 383-389.
12. Lu PJ, Zhou XZ, Liou YC, Noel JP, Lu KP, (2002) Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function. J Biol Chem 277: 2381-2384.
13. Uchida T, Takamiya M, Takahashi M, Miyashita H, Ikeda H, et al. (2003) Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem Biol 10: 15-24.
14. Hirotani T, Lee PY, Kuwata H, Yamamoto M, Matsumoto M, et al. (2005) The nuclear IkappaB protein IkappaBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria. J Immunol 174: 3650-3657.
15. Park P, Huang H, McMullen MR, Bryan K, Nagy LE, (2008) Activation of cyclic-AMP response element binding protein contributes to adiponectin-stimulated interleukin-10 expression in Raw 264.7 macrophages. J Leukoc Biol 83: 1258-1266.
16. Benkhart EM, Siedlar M, Wedel A, Werner T, Ziegler-Heitbrock HW, (2000) Role of Stat3 in lipopolysaccharide-induced IL-10 gene expression. J Immunol 165: 1612-1617.
17. Freundlich B, Avdalovic N, (1983) Use of gelatin/plasma coated flask for isolating human peripheral blood monocytes. J Immunol Methods 62: 31-37.
18. Akiyama H, Shin R, Uchida C, Kitamoto T, Uchida T, (2005) Prolyl isomerase Pin1 facilitates production of Alzheimer's amyloid beta from beta-cleaved amyloid precursor protein. Biochem Biophys Res Commun 336: 521-529.