Assessment of pre-diagnosis biomarkers of immune activation and inflammation: Insights on the etiology of Lymphoma

Journal of Proteome Research

Volumn 10, Issue 1, 2011, Pages 113-119

  Vendrame, Elena ^a   Martínez Maza, Otoniel ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Activation Induced Cytidine Deaminase; AID; AIDS; B lymphocytes; CSR; Cytokines; HIV; Lymphoma; NHL; SHM

Indexed keywords

BIOLOGICAL MARKER; CD23 ANTIGEN; CD27 ANTIGEN; CD30 ANTIGEN; CXCL13 CHEMOKINE; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HERMES ANTIGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 15; INTERLEUKIN 1ALPHA; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; B LYMPHOCYTE ACTIVATION; COHORT ANALYSIS; CYTOKINE PRODUCTION; EPSTEIN BARR VIRUS INFECTION; GENETIC RECOMBINATION; HUMAN; IMMUNOCOMPETENCE; IMMUNOREGULATION; IMMUNOSTIMULATION; INFLAMMATION; NONHODGKIN LYMPHOMA; PRIORITY JOURNAL; PROTEOMICS; REVIEW; SOMATIC HYPERMUTATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; BIOLOGICAL MARKERS; HUMANS; INFLAMMATION; LYMPHOMA, NON-HODGKIN;

HUMAN HERPESVIRUS 4;

EID: 79951534338     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr100729z     Document Type: Review

References (62)

1. Mantovani, A.; Allavena, P.; Sica, A.; Balkwill, F. Cancer-related inflammation. Nature 2008, 454 (7203), 436-44.
2. Pasqualucci, L.; Neumeister, P.; Goossens, T.; Nanjangud, G.; Chaganti, R. S.; Kuppers, R.; Dalla-Favera, R. Hypermuataion of multiple proto-oncogenes in B cell diffuse large-cell lymphomas. Nature 2001, 412, 341-6. (Pubitemid 32691848)
3. Martinez-Maza, O.; Moreno, A. D.; Cozen, W. Epidemiological Evidence: IgE, Allergies, and Hematopoietic Malignancies. In Cancer and IgE; Penichet, M. L., Jensen-Jarolim, E., Eds.; Springer: New York, 2010; pp 79-136.
4. Morton, L.; Wang, S. S.; Devesa, S. S.; Hartge, P.; Weisenburger, D.; Linet, M. Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001. Blood 2006, 107, 265-76. (Pubitemid 43053551)
5. Morton, L. M.; Wang, S. S.; Cozen, W.; Linet, M. S.; Chatterjee, N.; Davis, S.; Severson, R. K.; Colt, J. S.; Vasef, M. A.; Rothman, N.; Blair, A.; Bernstein, L.; Cross, A. J.; De Roos, A. J.; Engels, E. A.; Hein, D. W.; Hill, D. A.; Kelemen, L. E.; Lim, U.; Lynch, C. F.; Schenk, M.; Wacholder, S.; Ward, M. H.; Hoar Zahm, S.; Chanock, S. J.; Cerhan, J. R.; Hartge, P. Etiologic heterogeneity among non- Hodgkin lymphoma subtypes. Blood 2008, 112 (13), 5150-60.
6. Jaffe, E.; Harris, N.; Stein, H.; Vardiman, J. Pathology & Genetics of Tumours of Haematopoietic and Lymphoid Tissues; International Agency for Research on Cancer (IARC) Press: Lion, France, 2001.
7. Epeldegui, M.; Widney, D. P.; Martinez-Maza, O. Pathogenesis of AIDS lymphoma: role of oncogenic viruses and B cell activationassociated molecular lesions. Curr. Opin. Oncol. 2006, 18 (5), 444-8. (Pubitemid 44199839)
8. Pham, P.; Bransteitter, R.; Goodman, M. F. Reward versus risk: DNA cytidine deaminases triggering immunity and disease. Biochemistry 2005, 44 (8), 2703-15. (Pubitemid 40293648)
9. Pasqualucci, L.; Bhagat, G.; Jankovic, M.; Compagno, M.; Smith, P.; Muramatsu, M.; Honjo, T.; Morse, H. C., 3rd; Nussenzweig, M. C.; Dalla-Favera, R. AID is required for germinal center-derived lymphomagenesis. Nat. Genet. 2008, 40 (1), 108-12.
10. Epeldegui, M.; Breen, E. C.; Hung, Y. P.; Boscardin, W. J.; Detels, R.; Martinez-Maza, O. Elevated expression of activation induced cytidine deaminase in peripheral blood mononuclear cells precedes AIDS-NHL diagnosis. AIDS 2007, 21 (17), 2265-70. (Pubitemid 350287452)
11. Van Baarle, D.; Hovenkamp, E.; Callan, M. F.; Wolthers, K. C.; Kostense, S.; Tan, L. C.; Niesters, H. G.; Osterhaus, A. D.; Mc- Michael, A. J.; Van Oers, M. H.; Miedema, F. Dysfunctional Epstein- Barr virus (EBV)-specific CD8(+) T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma. Blood 2001, 98 (1), 146-55.
12. Gaidano, G.; Capello, D.; Carbone, A. The molecular basis of acquired immunodeficiency syndrome-related lymphomagenesis. Semin. Oncol. 2000, 27 (4), 431-41.
13. Goedert, J. J.; Cote, T. R.; Virgo, P.; Scoppa, S. M.; Kingma, D. W.; Gail, M. H.; Jaffe, E. S.; Biggar, R. J. Spectrum of AIDS-associated malignant disorders. Lancet 1998, 351 (9119), 1833-9. (Pubitemid 28279706)
14. Cote, T. R.; Biggar, R. J.; Rosenberg, P. S.; Devesa, S. S.; Percy, C.; Yellin, F. J.; Lemp, G.; Hardy, C.; Geodert, J. J.; Blattner, W. A. Non- Hodgkin's lymphoma among people with AIDS: incidence, presentation and public health burden. AIDS/Cancer Study Group. Int. J. Cancer 1997, 73 (5), 645-50. (Pubitemid 127483058)
15. Tulpule, A.; Levine, A. AIDS-related lymphoma. Blood Rev. 1999, 13 (3), 147-50. (Pubitemid 29472282)
16. Crotty, S.; Johnston, R. J.; Schoenberger, S. P. Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation. Nat. Immunol. , 11 (2), 114-20.
17. Romagnani, S.; Maggi, E.; Liotta, F.; Cosmi, L.; Annunziato, F. Properties and origin of human Th17 cells. Mol. Immunol. 2009, 47 (1), 3-7.
18. Martinez-Maza, O.; Breen, E. C. B-cell activation and lymphoma in patients with HIV. Curr. Opin. Oncol. 2002, 14 (5), 528-32.
19. Emery, P.; Luqmani, R. The validity of surrogate markers in rheumatic disease. Br. J. Rheumatol. 1993, 32 (Suppl 3), 3-8. (Pubitemid 23193419)
20. Porteu, F.; Nathan, C. Shedding of tumor necrosis factor receptors by activated human neutrophils. J. Exp. Med. 1990, 172 (2), 599-607. (Pubitemid 20248401)
21. Salazar-Gonzalez, J. F.; Martinez-Maza, O.; Aziz, N.; Kolberg, J. A.; Yeghiazarian, T.; Shen, L. P.; Fahey, J. L. Relationship of plasma HIV-RNA levels and levels of TNF-alpha and immune activation products in HIV infection. Clin. Immunol. Immunopathol. 1997, 84 (1), 36-45. (Pubitemid 27293542)
22. Zwingenberger, K.; Harms, G.; Pedrosa, C.; Omena, S.; Sandkamp, B.; Neifer, S. Determinants of the immune response in visceral leishmaniasis: evidence for predominance of endogenous interleukin 4 over interferon-gamma production. Clin. Immunol. Immunopathol. 1990, 57 (2), 242-9. (Pubitemid 20368037)
23. Martinez-Maza, O.; Crabb, E.; Mitsuyasu, R. T.; Fahey, J. L.; Giorgi, J. V. Infection with the human immunodeficiency virus (HIV) is associated with an in vivo increase in B lymphocyte activation and immaturity. J. Immunol. 1987, 138 (11), 3720-4. (Pubitemid 17078240)
24. Nakajima, K.; Martinez-Maza, O.; Hirano, T.; Breen, E. C.; Nishanian, P. G.; Salazar-Gonzalez, J. F.; Fahey, J. L.; Kishimoto, T. Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV. J. Immunol. 1989, 1422, 531-6. (Pubitemid 19039972)
25. Breen, E. C.; Rezai, A. R.; Nakajima, K.; Beall, G. N.; Mitsuyasu, R. T.; Hirano, T.; Kishimoto, T.; Martinez-Maza, O. Infection with HIV is associated with elevated IL-6 levels and production. J. Immunol. 1990, 144 (2), 480-4. (Pubitemid 20036072)
26. He, B.; Qiao, X.; Klasse, P. J.; Chiu, A.; Chadburn, A.; Knowles, D. M.; Moore, J. P.; Cerutti, A. HIV-1 envelope triggers polyclonal Ig class switch recombination through a CD40-independent mechanism involving BAFF and C-type lectin receptors. J. Immunol. 2006, 176 (7), 3931-41. (Pubitemid 44264370)
27. Epeldegui, M.; Thapa, D. R.; De La Cruz, J.; Kitchen, S. G.; Zack, J. A.; Martinez-Maza, O. CD40 Ligand (CD154) Incorporated into HIV Virions Induces Activation-Induced Cytidine Deaminase (AID) Expression in Human B Lymphocytes. PLoS One 2010, 5 (7), e11448.
28. Landgren, O.; Goedert, J. J.; Rabkin, C. S.; Wilson, W. H.; Dunleavy, K.; Kyle, R. A.; Katzmann, J. A.; Rajkumar, S. V.; Engels, E. A. Circulating serum free light chains as predictive markers of AIDSrelated lymphoma. J. Clin. Oncol. , 28 (5), 773-9.
29. Pluda, J. M.; Venzon, D. J.; Tosato, G.; Lietzau, J.; Wyvill, K.; Nelson, D. L.; Jaffe, E. S.; Karp, J. E.; Broder, S.; Yarchoan, R. Parameters affecting the development of non-Hodgkin's lymphoma in patients with severe human immunodeficiency virus infection receiving antiretroviral therapy. J. Clin. Oncol. 1993, 11 (6), 1099-107. (Pubitemid 23163350)
30. Breen, E. C.; van der Meijden, M.; Cumberland, W.; Kishimoto, T.; Detels, R.; Martinez-Maza, O. The development of AIDSassociated Burkitt's/small noncleaved cell lymphoma is preceded by elevated serum levels of interleukin 6. Clin. Immunol. 1999, 92 (3), 293-9. (Pubitemid 29439676)
31. Breen, E. C.; Boscardin, W. J.; Detels, R.; Jacobson, L. P.; Smith, M. W.; O'Brien, S. J.; Chmiel, J. S.; Rinaldo, C. R.; Lai, S.; Martinez-Maza, O. Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the IL10 promoter-592 C/C genotype. Clin. Immunol. 2003, 109 (2), 119-29. (Pubitemid 37338618)
32. Yawetz, S.; Cumberland, W. G.; van der Meyden, M.; Martinez- Maza, O. Elevated serum levels of soluble CD23 (sCD23) precede the appearance ofacquired immunodeficiency syndrome-associated non-Hodgkin's lymphoma. Blood 1995, 85 (7), 1843-9.
33. Schroeder, J. R.; Saah, A. J.; Ambinder, R. F.; Martinez-Maza, O.; Crabb Breen, E.; Variakojis, D.; Margolick, J. B.; Jacobson, L. P.; Rowe, D. T.; Hoover, D. R. Serum sCD23 level in patients with AIDS-related non-Hodgkin's lymphoma is associated with absence of Epstein-Barr virus in tumor tissue. Clin Immunol 1999, 93 (3), 239-44.
34. Schroeder, J. R.; Saah, A. J.; Hoover, D. R.; Margolick, J. B.; Ambinder, R. F.; Martinez-Maza, O.; Breen, E. C.; Jacobson, L. P.; Variakojis, D.; Rowe, D. T.; Armenian, H. K. Serum soluble CD23 level correlates with subsequent development of AIDS-related non- Hodgkin's lymphoma. Cancer Epidemiol. Biomarkers Prev. 1999, 8 (11), 979-84. (Pubitemid 29536090)
35. Widney, D. P.; Gui, D.; Popoviciu, L. M.; Said, J. W.; Breen, E. C.; Huang, X.; Kitchen C. M. R.; Alcantar, J. M.; Smith, J. B.; Detels, R.; Martinez-Maza, O. Expression and function of the chemokine, CXCL13, and its receptor, CXCR5, in AIDS-assocaited non- Hodgkin's lymphoma AIDS Res. Treat. 2010, in press; doi:10.1155/ 2010/164586.
36. Hussain, S. K.; Widney, D.; Jacobson, L. P.; Breen, E. C.; Levine, A.; Detels, R.; Zhang, Z.-F.; Martinez-Maza, O. In Elevated serum levels of CXCL13 precede HIV-associated non-Hodgkin's lymphoma; 12th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI), Bethesda, MD, 2010.
37. Grulich, A. E.; Wan, X.; Law, M. G.; Milliken, S. T.; Lewis, C. R.; Garsia, R. J.; Gold, J.; Finlayson, R. J.; Cooper, D. A.; Kaldor, J. M. B-cell stimulation and prolonged immune deficiency are risk factors for non-Hodgkin's lymphoma in people with AIDS. Aids 2000, 14 (2), 133-40. (Pubitemid 30116438)
38. Breen, E. C.; Magpantay, L.; Grodsky, M.; Detels, R.; Rabkin, C. S.; Kaslow, R. A.; Ambinder, R. F.; Jacobson, L. P.; Martinez-Maza, O. In Elevated B cell stimulatory cytokines preceding lymphoma in subjects with acquired immunodeficiency syndrome (AIDS) followed by non-Hodgkin's B cell lymphoma; American Association for Cancer Research (AACR): Los Angeles, CA, 2007.
39. Breen, E. C.; Fatahi, S.; Epeldegui, M.; Boscardin, W. J.; Detels, R.; Martinez-Maza, O. Elevated serum soluble CD30 precedes the development of AIDS-associated non-Hodgkin's B cell lymphoma. Tumour Biol. 2006, 27 (4), 187-94.
40. Widney, D.; Gundapp, G.; Said, J. W.; van der Meijden, M.; Bonavida, B.; Demidem, A.; Trevisan, C.; Taylor, J.; Detels, R.; Martinez-Maza, O. Aberrant expression of CD27 and soluble CD27 (sCD27) in HIV infection and in AIDS-associated lymphoma. Clin. Immunol. 1999, 93 (2), 114-23. (Pubitemid 29523387)
41. De Milito, A.; Morch, C.; Sonnerborg, A.; Chiodi, F. Loss of memory (CD27) B lymphocytes in HIV-1 infection. AIDS 2001, 15 (8), 957-64. (Pubitemid 32476662)
42. Breen, E. C.; Epeldegui, M.; Boscardin, W. J.; Widney, D. P.; Detels, R.; Martinez-Maza, O. Elevated levels of soluble CD44 precede the development of AIDS-associated non-Hodgkin's B-cell lymphoma. AIDS 2005, 19 (15), 1711-2. (Pubitemid 41502693)
43. Muller, G.; Hopken, U. E.; Lipp, M. The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity. Immunol. Rev. 2003, 195, 117-35. (Pubitemid 37153458)
44. Moser, B.; Schaerli, P.; Loetscher, P. CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responses. Trends Immunol. 2002, 23 (5), 250-4. (Pubitemid 34499562)
45. Rabkin, C. S.; Engels, E. A.; Landgren, O.; Schuuman, R.; Goedert, J. J. In Circulating cytokine levels, Epstein-Barr viremia and risk of AIDS-related non-Hodgkin lymphoma; AACR 101st Annual Meeting 2010, Washington, DC, 2010.
46. Purdue, M. P.; Lan, Q.; Martinez-Maza, O.; Oken, M. M.; Hocking, W.; Huang, W. Y.; Baris, D.; Conde, B.; Rothman, N. A prospective study of serum soluble CD30 concentration and risk of non- Hodgkin lymphoma. Blood 2009, 114 (13), 2730-2.
47. Levin, L.; Kitchen, C. M. R.; Widney, D.; Kim, B.; Marrogi, A.; Krampf, R.; Magpantay, L.; Martinez-Maza, O. Elevated Serum Levels of CXCL13 Precede the Diagnosis of B Cell Non Hodgkin Lymphoma (NHL). In The Future of Molecular Epidemiology: New Tools, Biomarkers, and Opportunities; AARC: Miami, FL, 2010.
48. Takagi, R.; Higashi, T.; Hashimoto, K.; Nakano, K.; Mizuno, Y.; Okazaki, Y.; Matsushita, S. B cell chemoattractant CXCL13 is preferentially expressed by human Th17 cell clones. J. Immunol. 2008, 181 (1), 186-9.
49. Annunziato, F.; Romagnani, S. Do studies in humans better depict Th17 cells. Blood 2009, 114 (11), 2213-9.
50. Annunziato, F.; Cosmi, L.; Santarlasci, V.; Maggi, L.; Liotta, F.; Mazzinghi, B.; Parente, E.; Fili, L.; Ferri, S.; Frosali, F.; Giudici, F.; Romagnani, P.; Parronchi, P.; Tonelli, F.; Maggi, E.; Romagnani, S. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 2007, 204 (8), 1849-61. (Pubitemid 47240944)
51. Ishikawa, S. Aberrant high expression of B lymphocyte chemoattractant (BLC/CXCL13) in a murine model for SLE. Tanpakushitsu Kakusan Koso 2002, 47 (16 Suppl), 2369-74.
52. Hansen, A.; Lipsky, P. E.; Dorner, T. B cells in Sjogren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue. Arthritis Res. Ther. 2007, 9 (4), 218.
53. Sellebjerg, F.; Bornsen, L.; Khademi, M.; Krakauer, M.; Olsson, T.; Frederiksen, J. L.; Sorensen, P. S.; Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active, M. S. Neurology 2009, 73 (23), 2003-10.
54. Ekstrom Smedby, K.; Vajdic, C. M.; Falster, M.; Engels, E. A.; Martinez-Maza, O.; Turner, J.; Hjalgrim, H.; Vineis, P.; Seniori Costantini, A.; Bracci, P. M.; Holly, E. A.; Willett, E.; Spinelli, J. J.; La Vecchia, C.; Zheng, T.; Becker, N.; De Sanjose, S.; Chiu, B. C.; Dal Maso, L.; Cocco, P.; Maynadie, M.; Foretova, L.; Staines, A.; Brennan, P.; Davis, S.; Severson, R.; Cerhan, J. R.; Breen, E. C.; Birmann, B.; Grulich, A. E.; Cozen, W. Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium. Blood 2008, 111 (8), 4029-38.
55. Saberi Hosnijeh, F.; Krop, E. J.; Scoccianti, C.; Krogh, V.; Palli, D.; Panico, S.; Tumino, R.; Sacredote, C.; Nawroly, N.; Portengen, L.; Linseisen, J.; Vineis, P.; Vermeulen, R. Plasma cytokines and future risk of non-Hodgkin lymphoma (NHL): a case-control study nested in the Italian European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiol. Biomarkers Prev19 , (6), 1577-84.
56. Gu, Y.; Shore, R. E.; Arslan, A. A.; Koenig, K. L.; Liu, M.; Ibrahim, S.; Lokshin, A. E.; Zeleniuch-Jacquotte, A. Circulating cytokines and risk of B-cell non-Hodgkin lymphoma: a prospective study. Cancer Causes Control 2010, 21 (8), 1323-33.
57. Wagner-Johnston, N. D.; Nurmemet, D.; Gocke, C.; Lin, L.; Lemas, V. M.; Martinez-Maza, O.; Ambinder, R. F. In Clonal heavy and light chain immunoglobulin DNA in plasma/serum of AIDS lymphoma patients; American Society for Hematology Annual Meeting; American Society for Hematology: Atlanta, GA, 2007.
58. Lee, Y. H.; Wong, D. T. Saliva: an emerging biofluid for early detection of diseases. Am. J. Dent. 2009, 22 (4), 241-8.
59. Zamo, A.; Cecconi, D. Proteomic analysis of lymphoid and haematopoietic neoplasms: there's more than biomarker discovery. J. Proteomics , 73 (3), 508-20.
60. Zhang, X.; Wang, B.; Zhang, X. S.; Li, Z. M.; Guan, Z. Z.; Jiang, W. Q. Serum diagnosis of diffuse large B-cell lymphomas and further identification of response to therapy using SELDI-TOF-MS and tree analysis patterning. BMC Cancer 2007, 7, 235.
61. Berek, J. S.; Chung, C.; Kaldi, K.; Watson, J. M.; Knox, R. M.; Martinez-Maza, O. Serum interleukin-6 levels correlate with disease status in patients with epithelial ovarian cancer. Am. J. Obstet. Gynecol. 1991, 164 (4), 1038-42; discussion 1042-3.
62. Watson, J. M.; Sensintaffar, J. L.; Berek, J. S.; Martinez-Maza, O. Constitutive production of interleukin 6 by ovarian cancer cell lines and by primary ovarian tumor cultures. Cancer Res. 1990, 50 (21), 6959-65. (Pubitemid 20361098)