Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the IL10 promoter -592 C/C genotype

Clinical Immunology

Volumn 109, Issue 2, 2003, Pages 119-129

  Breen, Elizabeth Crabb ^a   Boscardin, W John ^b   Detels, Roger ^b   Jacobson, Lisa P ^c   Smith, Michael W ^d   O'Brien, Stephen J ^e   Chmiel, Joan S ^f   Rinaldo, Charles R ^g   Lai, Shenghan ^c   Martínez Maza, Otoniel ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d SAIC FREDERICK INC   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

^f NORTHWESTERN UNIVERSITY   (United States)

^g UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

AIDS; B cell; Cytokine; Genotype; Haplotype; Interleukin 10; Lymphoma; Predictor; Serum; Single nucleotide polymorphism

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 10;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AIDS ASSOCIATED LYMPHOMA; ARTICLE; B CELL LYMPHOMA; COHORT ANALYSIS; CONTROLLED STUDY; DEVICE; DISEASE ASSOCIATION; DISEASE COURSE; GENE; GENE EXPRESSION; GENETIC ANALYSIS; GENOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCIDENCE; LONGITUDINAL STUDY; LYMPHOMA; MAJOR CLINICAL STUDY; PATIENT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; RACE; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 0242365463     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1521-6616(03)00214-6     Document Type: Article

References (43)

1. Scherr P.A., Mueller N.E. Non-Hodgkin's lymphomas. Schottenfeld D., Fraumeni J.F. Jr. Cancer Epidemiology and Prevention. 1996;920-945 Oxford University Press, Oxford.
2. Frisch M., Biggar R.J., Engels E.A., Goedert J.J. Association of cancer with AIDS-related immunosuppression in adults. J. Am. Med. Assoc. 285:2001;1736-1745.
3. Rosenberg Z.F., Fauci A.S. Immunopathogenic mechanisms of HIV infection cytokine induction of HIV expression . Immunol. Today. 11:1990;176-180.
4. Martínez-Maza O., Widney D., van der Meijden M., Knox R., Echeverri A., Breen E.C., Magpantay L., Miles S.A. Immune dysfunction and the pathogenesis of AIDS-associated non-Hodgkin's lymphoma. Memórias Inst. Oswaldo Cruz. 93:1998;373-381.
5. Lane H.C., Fauci A.S. Immunologic abnormalities in AIDS. Annu. Rev. Immunol. 3:1985;477-500.
6. Lane H.C., Masur H., Edgar L.C., Whalen G., Rook A.H., Fauci A. Abnormalities of B-cell activation and immunoregulation in patients with AIDS. N. Engl. J. Med. 30:1983;453-458.
7. Martínez-Maza O., Crabb E., Mitsuyasu R.T., Fahey J.L., Giorgi J.V. Infection with HIV is associated with an in vivo increase in B lymphocyte activation and immaturity. J. Immunol. 138:1987;3720-3724.
8. Mizuma H., Litwin S., Zolla-Pazner S. B cell activation in HIV infection relationship of spontaneous immunoglobulin secretion to various immunologic parameters . Clin. Exp. Immunol. 71:1988;410-416.
9. van der Meijden M., Gage J., Breen E.C., Taga T., Kishimoto T., Martinez-Maza O. Upregulation of IL-6 receptor (CD126) expression on monocytes, B lymphocytes and CD4 T lymphocytes in HIV infection. Cell. Immunol. 190:1998;156-166. doi:10.1006/cimm.1998.1387.
10. Przybylski G.K., Goldman J., Ng V.L., McGrath M.S., Herndier B.G., Schenkein D.P., Monroe J.G., Silberstein L.E. Evidence for early B-cell activation preceding the development of Epstein-Barr virus-negative acquired immunodeficiency syndrome-related lymphoma. Blood. 88:1996;4620-4629.
11. Yawetz S., Cumberland W.G., van der Meyden M., Martinez-Maza O. Elevated serum levels of soluble CD23 (sCD23) precede the appearance of AIDS-associated non-Hodgkin's lymphoma. Blood. 85:1995;1843-1849.
12. Schroeder J., Saah A.J., Hoover D.R., Margolick J.B., Ambinder R.F., Martínez-Maza O., Breen E.C., Jacobson L.P., Variakojis D., Rowe D.T., Armenian H.K. Serum soluble CD23 level correlates with subsequent development of AIDS-related non-Hodgkin's lymphoma. Cancer Epidemiol. Biomark. Prev. 8:1999;979-984.
13. Schroeder J., Saah A., Ambinder R.F., Martínez-Maza O., Breen E.C., Variakojis D., Margolick J.B., Jacobson L.P., Rowe D.T., Hoover D.R. Serum sCD23 level in patients with AIDS-related non-Hodgkin's lymphoma is associated with the absence of EBV in tumor tissue. Clin. Immunol. 93:1999;239-244. doi:10.1006/clim.1999.4793.
14. Widney D., Gundapp G., Said J.W., van der Meijden M., Bonavida B., Demidem A., Trevisan C., Taylor J., Detels R., Martínez-Maza O. Aberrant expression of CD27 and soluble CD27 (sCD27) in HIV infection and in AIDS-associated lymphoma. Clin. Immunol. 93:1999;114-123. doi:10.1006/clim.1999. 4782.
15. Breen E.C., van der Meijden M., Cumberland W., Kishimoto T., Detels R., Martínez-Maza O. The development of AIDS-associated Burkitt's/small non-cleaved lymphoma is preceded by elevated serum levels of interleukin 6. Clin. Immunol. 92:1999;293-298. doi:10.1006/clim.1999.4760.
16. Moore K.W., de Waal Malefyt R., Coffman R.L., O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19:2001;683-765.
17. Emilie D., Coumbaras J., Raphael M., Devergne O., Delecluse H.J., Gisselbrecht C., Michiels J.F., Van Damme J., Taga T., Kishimoto T., Crevon M.C., Galanaud P. IL-6 production in high-grade B lymphomas correlation with the presence of malignant immunoblasts in acquired immunodeficiency syndrome and in human immunodeficiency virus-seronegative patients . Blood. 80:1992;498-504.
18. Emilie D., Touitou R., Raphael M., Peuchmaur M., Devergnee O., Rea D., Coumbraras J., Crevon M.-C., Edelman L., Galanaud I., Job P. In vivo production of interleukin-10 by malignant cells in AIDS lymphoma. Eur. J. Immunol. 22:1992;2937-2942.
19. Emile D., Zou W., Fior R., Llorente L., Durandy A., Crevon M.C., Maillot M.C., Durand-Gasselin I., Raphael M., Peuchmaur M., Galanaud P. Production and roles of IL-6, IL-10, and IL-13 in B-lymphocyte malignancies and in B-lymphocyte hyperactivity of HIV infection and autoimmunity. Methods. 11:1997;133-142. doi:10.1006/meth.1996.0397.
20. Masood R., Zhang Y., Bond M.W., Scadden D.T., Moudgil T., Law R.E., Kaplan M.H., June B., Espina B.M., Lunardi-Iskandar Y., Levine A.M., Gill P.S. Interleukin-10 is an autocrine growth factor of Acquired Immunodeficiency Syndrome-related B-cell lymphoma. Blood. 85:1995;3423-3430.
21. Edelman L., Deveau C., Raphael M., Monchatre E., Gabarre J., Deville-Chabrol A., Pialoux G., Emilie D., Joab I., Galanaud P. Serum interleukin-10 in acquired immunodeficiency syndrome lymphoma patients. Seroco-Hemoco Study Group. Eur. Cytokine Network. 7:1996;785-792.
22. Crawley E., Kay R., Sillibourne J., Patel P., Hutchinson I., Woo P. Polymorphic haplotypes of the interluekin-10 5′ flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum. 42:1999;1101-1108.
23. Turner D.M., Williams D.M., Sankaran D., Lazarus M., Sinnott P.J., Hutchinson I.V. An investigation of polymorphism in the interleukin-10 gene promoter. Eur. J. Immunogenet. 24:1997;1-8.
24. Edwards-Smith C.J., Jonsson J.R., Purdie D.M., Bansal A., Shorthouse C., Powell E.E. Interlukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alpha. Hepatology. 30:1999;526-530.
25. Shin H.D., Winkler C., Stephens J.C., Bream J., Young H., Goedert J.J., O'Brien T.R., Vlahov D., Buchbinder S., Giorgi J., Rinaldo C., Donfield S., Willoughby A., O'Brien S.J., Smith M.W. Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10. Proc. Natl. Acad. Sci. USA. 97:2000;14467-14472.
26. Kaslow R.A., Ostrow D.G., Detels R., Phair J.P., Polk B.F., Rinaldo C.R. The Multicenter AIDS Cohort Study rationale, organization and selected characteristics of the participants . Am. J. Epidemiol. 126:1987;310-318.
27. Detels R., Phair J.P., Saah A.J., Rinaldo C.R., Muñoz A., Kaslow R.A., Seminara D., Schrager L., Vermund S. Recent scientific contributions to understanding HIV/AIDS from the Multicenter AIDS Cohort Study. J. Epidemiol. (Japan). 2:1992;S11-19.
28. Lindblad-Toh K., Winchester E., Daly M.J., Wang D.G., Hirschhorn J.N., Laviolette J.P., Ardlie K., Reich D.E., Robinson E., Sklar P., Shah N., Thomas D., Fan J.B., Gingeras T., Warrington J., Patil N., Hudson T.J., Lander E.S. Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nat. Genet. 24:2000;381-386.
29. Rossenwasser L.J., Borish L. Genetics of atopy and asthma the rationale behind promoter-based candidate gene studies (IL-4 and IL-10) . Am. J. Respir. Crit. Care Med. 156:1997;S152-155.
30. Reynard M.P., Tumer D., Navarrete C.V. Allele frequencies of polymorphisms of the tumour necrosis factor-α, interleukin-10, interferon-γ and interleukin-2 genes in a North European Caucasoid group from the UK. Eur. J. Immunogenet. 27:2000;241-249.
31. Stanczuk G.A., Sibanda E.N., Perrey C., Chirara M., Pravica V., Hutchinson I.V., Tswana S.A. Cancer of the uterine cervix may be significantly associated with a gene polymorphism coding for increased IL-10 production. Int. J. Cancer. 94:2001;792-794.
32. Hoffmann S.C., Stanley E.M., Cox E.D., Craighead N., DiMercurio A.B., Koziol D.E., Harlan D.M., Kirk A.D., Blair P.J. Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28- stimulated peripheral blood lymphocytes. Transplantation. 72:2001;1444-1450.
33. Blay J.Y., Burdin N., Rousset F., Lenoir G., Biron P., Philip T., Banchereau J., Favrot M.C. Serum interleukin-10 in non-Hodgkin's lymphoma a prognostic factor . Blood. 82:1993;2169-2174.
34. Müller F., Aukrust P., Nordøy I., Frøland S.S. Possible role of interleukin-10 (IL-10) and CD40 ligand expression in the pathogenesis of hypergammaglobulinemia in human immunodeficiency virus infection modulation of IL-10 and Ig production after intravenous Ig infusion . Blood. 92:1998;3721-3729.
35. Stylianou E., Aukrust P., Kvale D., Müller F., Frøland S.S. IL-10 in HIV infection increasing serum IL-10 levels with disease progression - down-regulatory effect of potent anti-retroviral therapy . Clin. Exp. Immunol. 116:1999;115-120.
36. Dean M., Jacobson L.P., McFarlane G., Margolick J.B., Jenkins F.J., Howard O.M., Dong H.F., Goedert J.J., Buchbinder S., Gompers E., Vlahov D., Oppenheim J.J., O'Brien S.J., Carrington M. Reduced risk of AIDS lymphoma in individuals heterozygous for the CCR5-delta32 mutation. Cancer Res. 59:1999;3561-3564.
37. Lehrnbecher T.L., Foster C.B., Zhu S., Venzon D., Steinberg S.M., Wyvill K., Metcalf J.A., Cohen S.S., Kovacs J., Yarchoan R., Blauvelt A., Chanock S.J. Variant genotypes of Fcγ RIIIA influence the development of Kaposi's sarcoma in HIV-infected men. Blood. 95:2000;2386-2390.
38. Foster C.B., Lehrnbecher T., Samuels S., Stein S., Mol F., Metcalf J.A., Wyvill K., Steinberg S.M., Kovacs J., Blauvelt A., Yarchoan R., Chanock S.J. An IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi's sarcoma in men infected with human immunodeficiency virus. Blood. 96:2000;2562-2567.
39. Rabkin C.S., Yang Q., Goedert J.J., Nguyen G., Mitsuya H., Sei S. Chemokine and chemokine receptor gene variants and risk of non-Hodgkin's lymphoma in human immunodeficiency virus-1-infected individuals. Blood. 93:1999;1838-1842.
40. Sei S., O'Neill D.P., Stewart S.K., Yang Q., Kumagi M., Boler A.M., Adde M.A., Zwerski S.L., Wood L.V., Vernon D.J., Magrath I.T. Increased level of stromal cell-derived factor-1 in peripheral blood mononuclear cells from children with AIDS-related lymphoma. Cancer Res. 61:2001;5028-5037.
41. Roh J.W., Kim M.H., Seo S.S., Kim S.H., Kim J.W., Park N.H., Song Y.S., Park S.Y., Kang S.B., Lee H.P. Interleukin-10 promoter polymorphisms and cervical cancer risk in Korean women. Cancer Lett. 184:2002;57-63. doi:10.1016/S0304-383S(02)00193-3.
42. Kilpinen S., Huhtala H., Hurme M. The combination of the interleukin-1alpha (IL-1alpha-889) genotype and the interleukin-10 (IL-10 ATA) haplotype is associated with increased interleukin-10 (IL-10) plasma levels in healthy individuals. Eur. Cytokine Network. 13:2002;66-71.
43. Suárez A., Castro P., Alonso R., Mozo L., Gutiérrez C. Interindividual variations in constitutive interleukin-10 messenger RNA and protein levels and their association with genetic polymorphisms. Transplantation. 75:2003;711-717.