Novel 3-aryl indoles as progesterone receptor antagonists for uterine fibroids

ACS Medicinal Chemistry Letters

Volumn 2, Issue 2, 2011, Pages 148-153

  Richardson, Timothy I ^a   Clarke, Christian A ^a   Yu, Kuo Long ^a   Yee, Ying K ^a   Bleisch, Thomas J ^a   Lopez, Jose E ^a   Jones, Scott A ^a   Hughes, Norman E ^a   Muehl, Brian S ^a   Lugar, Charles W ^a   Moore, Terry L ^a   Shetler, Pamela K ^a   Zink, Richard W ^a   Osborne, John J ^a   Montrose Rafizadeh, Chahrzad ^a   Patel, Nita ^a   Geiser, Andrew G ^a   Galvin, Rachelle J Sells ^a   Dodge, Jeffrey A ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

NR3C3; Progesterone; progesterone receptor; progesterone receptor antagonist; Suzuki cross coupling reaction; uterine fibroids

Indexed keywords

2 BROMO 6 NITRO INDOLE; ASOPRISNIL; INDOLE DERIVATIVE; MIFEPRISTONE; MINERALOCORTICOID RECEPTOR; PROGESTERONE; STEROID HORMONE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; DRUG ANTAGONISM; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; SUZUKI REACTION; UTERUS MYOMA;

RATTUS;

EID: 79951526115     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml100220b     Document Type: Article

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