Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 13, 2007, Pages 3544-3549

  Richardson, Timothy I ^a   Frank, Scott A ^a   Wang, Minmin ^a   Clarke, Christian A ^a   Jones, Scott A ^a   Ying, Bai Ping ^a   Kohlman, Dan T ^a   Wallace, Owen B ^a   Shepherd, Timothy A ^a   Dally, Robert D ^a   Palkowitz, Alan D ^a   Geiser, Andrew G ^a   Bryant, Henry U ^a   Henck, Judith W ^a   Cohen, Ilene R ^a   Rudmann, Daniel G ^a   McCann, Denis J ^a   Coutant, David E ^a   Oldham, Samuel W ^a   Hummel, Conrad W ^b   Fong, Kin C ^b   Hinklin, Ronald ^b   Lewis, George ^b   Tian, Hongqi ^b   Dodge, Jeffrey A ^a   more..

^a ELI LILLY AND COMPANY   (United States)

^b ARRAY BIOPHARMA INC   (United States)

Author keywords

Blood brain barrier; ER; Estrogen; Estrogen receptor; HPO axis; Hypothalamic pituitary ovarian axis; Leiomyomas; Selective estrogen receptor modulator; SERM; Uterine fibroids

Indexed keywords

4 HYDROXYTAMOXIFEN; BENZOTHIOPHENE; CLOMIFENE; ESTROGEN; ESTROGEN RECEPTOR; ETHINYLESTRADIOL; FOLLITROPIN; GONADORELIN; GONADORELIN AGONIST; LUTEINIZING HORMONE; NAPHTHALENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE MARKER; DRUG ANTAGONISM; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; ESTROGEN BLOOD LEVEL; FEMALE; HUMAN; HUMAN CELL; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IC 50; NONHUMAN; OSTEOLYSIS; OVARY; OVARY CYST; RAT; SIDE EFFECT; STIMULATION; STRUCTURE ACTIVITY RELATION; UTERUS; UTERUS MYOMA;

ANIMALS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ESTROGENS; FEMALE; HUMANS; LEIOMYOMA; MODELS, CHEMICAL; OVARY; RATS; RATS, SPRAGUE-DAWLEY; SELECTIVE ESTROGEN RECEPTOR MODULATORS; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34250173512     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.04.044     Document Type: Article

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