Identifying LRRC16B as an oncofetal gene with transforming enhancing capability using a combined bioinformatics and experimental approach

Oncogene

Volumn 30, Issue 6, 2011, Pages 654-667

  Hsu, C C ^a   Chiang, C W ^a   Cheng, H C ^a   Chang, W T ^a   Chou, C Y ^b   Tsai, H W ^b   Lee, C T ^b   Wu, Z H ^a   Lee, T Y ^a   Chao, A ^c   Chow, N H ^a,b   Ho, C L ^a,b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

expressed sequence tags; LRRC16B; oncofetal genes

Indexed keywords

ALPHA FETOPROTEIN; ALPHA INTEGRIN; BONE MORPHOGENETIC PROTEIN 4; BRAIN NATRIURETIC PEPTIDE; CHORIONIC GONADOTROPIN BETA SUBUNIT; CYCLIN B1; EPHRIN RECEPTOR B3; FIBROBLAST GROWTH FACTOR 18; MATRIX METALLOPROTEINASE 16; ONCOFETAL ANTIGEN; ONCOPROTEIN; PHOSPHODIESTERASE IV; PROTEIN LRRC16B; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOINFORMATICS; CANCER CELL CULTURE; CARCINOGENESIS; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DOWN REGULATION; EXPERIMENTAL STUDY; EXPRESSED SEQUENCE TAG; FEMALE; FETUS; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INFANT; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; TUMOR XENOGRAFT;

ANIMALS; ANTIGENS, NEOPLASM; CARRIER PROTEINS; CELL LINE; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COMPUTATIONAL BIOLOGY; CRICETINAE; CYCLIN B1; DATABASES, GENETIC; EXPRESSED SEQUENCE TAGS; FEMALE; HUMANS; MICE; MICE, INBRED NOD; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79951517321     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.451     Document Type: Article

References (48)

1. Adachi-Yamada T, Harumoto T, Sakurai K, Ueda R, Saigo K, O'Connor MB et al. (2005). Wing-to-leg homeosis by spineless causes apoptosis regulated by Fish-lips, a novel leucine-rich repeat transmembrane protein. Mol Cell Biol 25: 3140-3150. (Pubitemid 40464316)
2. Alexander P. (1970). Mechanism of growth and dissemination of antigenic tumors in normal immunological carriers. Medicina (B Aires) 30: 176-183.
3. Aouacheria A, Navratil V, Barthelaix A, Mouchiroud D, Gautier C. (2006). Bioinformatic screening of human ESTs for differentially expressed genes in normal and tumor tissues. BMC Genom 7: 94.
4. Barker N, Ridgway RA, van Es JH, van de Wetering M, Begthel H, van den Born M et al. (2009). Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457: 608-611.
5. Bergstrand CG, Czar B. (1956). Demonstration of a new protein fraction in serum from the human fetus. Scand J Clin Lab Invest 8: 174.
6. Boguski MS, Schuler GD. (1995). Establishing a human transcript map. Nat Genet 10: 369-371.
7. Boiani M, Scholer HR. (2005). Regulatory networks in embryo-derived pluripotent stem cells. Nat Rev Mol Cell Biol 6: 872-884. (Pubitemid 41568736)
8. Campagne F, Skrabanek L. (2006). Mining expressed sequence tags identifies cancer markers of clinical interest. BMC Bioinform 7: 481.
9. Chen CM, Kraut N, Groudine M, Weintraub H. (1996). I-mf, a novel myogenic repressor, interacts with members of the MyoD family. Cell 86: 731-741. (Pubitemid 26303442)
10. Cleynen I, Brants JR, Peeters K, Deckers R, Debiec-Rychter M, Sciot R et al. (2007). HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB. Mol Cancer Res 5: 363-372. (Pubitemid 46706998)
11. Colantuoni C, Purcell AE, Bouton CM, Pevsner J. (2000). High throughput analysis of gene expression in the human brain. J Neurosci Res 59: 1-10. (Pubitemid 30038858)
12. Cowin AJ, Adams DH, Strudwick XL, Chan H, Hooper JA, Sander GR et al. (2007). Flightless I deficiency enhances wound repair by increasing cell migration and proliferation. J Pathol 211: 572-581. (Pubitemid 46502434)
13. Dao DY, Yang X, Chen D, Zuscik M, O'Keefe RJ. (2007). Axin1 and Axin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways. Ann N Y Acad Sci 1116: 82-99. (Pubitemid 350274352)
14. Ding S, Schultz PG. (2004). A role for chemistry in stem cell biology. Nat Biotechnol 22: 833-840. (Pubitemid 38886601)
15. Eisenmann KM, Harris ES, Kitchen SM, Holman HA, Higgs HN, Alberts AS. (2007). Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex. Curr Biol 17: 579-591. (Pubitemid 46497803)
16. Esteve P, Bovolenta P. (2006). Secreted inducers in vertebrate eye development: more functions for old morphogens. Curr Opin Neurobiol 16: 13-19. (Pubitemid 43221848)
17. Farghaly SA. (1992). Tumor markers in gynecologic cancer. Gynecol Obstet Invest 34: 65-72.
18. Fukada M, Watakabe I, Yuasa-Kawada J, Kawachi H, Kuroiwa A, Matsuda Y et al. (2000). Molecular characterization of CRMP5, a novel member of the collapsin response mediator rotein family. J Biol Chem 275: 37957-37965. (Pubitemid 32004917)
19. Gabory A, Ripoche MA, Yoshimizu T, Dandolo L. (2006). The H19 gene: regulation and function of a non-coding RNA. Cytogenet Genome Res 113: 188-193.
20. Garcia-Barcelo MM, Lau DK, Ngan ES, Leon TY, Liu TT, So MT et al. (2007). Evaluation of the thyroid transcription factor-1 gene (TITF1) as a Hirschsprung's disease locus. Ann Hum Genet 71: 746-754. (Pubitemid 47517258)
21. Gilboa E. (1999). How tumors escape immune destruction and what we can do about it. Cancer Immunol Immunother 48: 382-385. (Pubitemid 29461391)
22. Giles RH, van Es JH, Clevers H. (2003). Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 1653: 1-24. (Pubitemid 36627817)
23. Grozdanov PN, Yovchev MI, Dabeva MD. (2006). The oncofetal protein glypican-3 is a novel marker of hepatic progenitor/oval cells. Lab Invest 86: 1272-1284. (Pubitemid 44789916)
24. Hishinuma M, Ohashi KI, Yamauchi N, Kashima T, Uozaki H, Ota S et al. (2006). Hepatocellular oncofetal protein, glypican 3 is a sensitive marker for alpha-fetoprotein-producing gastric carcinoma. Histopathology 49: 479-486. (Pubitemid 44631620)
25. Hossain MS, Ozaki T, Wang H, Nakagawa A, Takenobu H, Ohira M et al. (2008). N-MYC promotes cell proliferation through a direct transactivation of neuronal leucine-rich repeat protein-1 (NLRR1) gene in neuroblastoma. Oncogene 27: 6075-6082.
26. Imamura F, Nagao H, Naritsuka H, Murata Y, Taniguchi H, Mori K. (2006). A leucine-rich repeat membrane protein, 5T4, is expressed by a subtype of granule cells with dendritic arbors in specific strata of the mouse olfactory bulb. J Comp Neurol 495: 754-768.
27. Kato T, HayamaS, Yamabuki T, Ishikawa N, Miyamoto M, Ito T et al. (2007). Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer. Clin Cancer Res 13: 434-442. (Pubitemid 46225347)
28. Katoh M. (2007). Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis. Stem Cell Rev 3: 30-38. (Pubitemid 47472809)
29. Katoh M, Katoh M. (2007). WNT antagonist, DKK2, is a Notch signaling target in intestinal stem cells: augmentation of a negative regulation system for canonical WNT signaling pathway by the Notch-DKK2 signaling loop in primates. Int J Mol Med 19: 197-201.
30. Kobe B, Kajava AV. (2001). The leucine-rich repeat as a protein recognition motif. Curr Opin Struct Biol 11: 725-732. (Pubitemid 34076634)
31. Kopecki Z, Cowin AJ. (2008). Flightless I: an actin-remodelling protein and an important negative regulator of wound repair. Int J Biochem Cell Biol 40: 1415-1419. (Pubitemid 351626699)
32. Kutay U, Guttinger S. (2005). Leucine-rich nuclear-export signals: born to be weak. Trends Cell Biol 15: 121-124. (Pubitemid 40332533)
33. Liu CI, Cheng TL, Chen SZ, Huang YC, Chang WT. (2005). LrrA, a novel leucine-rich repeat protein involved in cytoskeleton remodeling, is required for multicellular morphogenesis in Dictyostelium discoideum. Dev Biol 285: 238-251.
34. Matouk IJ, DeGroot N, Mezan S, Ayesh S, Abu-lail R, Hochberg A et al. (2007). The H19 non-coding RNA is essential for human tumor growth. PLoS ONE 2: e845.
35. McNamee D. (1995). Beta-hCG inhibits Kaposi's sarcoma. Lancet 345: 1169.
36. Monk M, Holding C. (2001). Human embryonic genes re-expressed in cancer cells. Oncogene 20: 8085-8091. (Pubitemid 34028332)
37. Morton JP, Mongeau ME, Klimstra DS, Morris JP, Lee YC, Kawaguchi Y et al. (2007). Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci USA 104: 5103-5108. (Pubitemid 47186183)
38. Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC. (1999). A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. Mol Cell Biol 19: 1262-1270. (Pubitemid 29046868)
39. Niemann H, Carnwath JW, Kues W. (2007). Application of DNA array technology to mammalian embryos. Theriogenology 68(Suppl 1): S165-S177. (Pubitemid 47103202)
40. Park TJ, Kim JY, Park SH, Kim HS, Lim IK. (2009). Skp2 enhances polyubiquitination and degradation of TIS21/BTG2/PC3, tumor suppressor protein, at the downstream of FoxM1. Exp Cell Res 315: 3152-3162.
41. Qiao M, Iglehart JD, Pardee AB. (2007). Metastatic potential of 21T human breast cancer cells depends on Akt/protein kinase B activation. Cancer Res 67: 5293-5299. (Pubitemid 46997268)
42. Sarandakou A, Protonotariou E, Rizos D. (2007). Tumor markers in biological fluids associated with pregnancy. Crit Rev Clin Lab Sci 44: 151-178.
43. Shimokawa T, Furukawa Y, Sakai M, Li M, Miwa N, Lin YM et al (2003). Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex. Cancer Res 63: 6116-6120. (Pubitemid 37255147)
44. Sugimori M, Nagao M, Parras CM, Nakatani H, Lebel M, Guillemot F et al. (2008). Ascl1 is required for oligodendrocyte development in the spinal cord. Development 135: 1271-1281. (Pubitemid 351622471)
45. Trojan J, Naval X, Johnson T, Lafarge-Frayssinet C, Hajeri-Germond M, Farges O et al. (1995). Expression of serum albumin and of alphafetoprotein in murine normal and neoplastic primitive embryonic structures. Mol Reprod Dev 42:369-378.
46. Vogelstein B, Kinzler KW. (2004). Cancer genes and the pathways they control. Nat Med 10: 789-799. (Pubitemid 39070849)
47. Wang R, Kaul A, Sperry AO. (2009). TLRR (lrrc67) interacts with PP1 and is associated with a cytoskeletal complex in the testis. Biol Cell 102: 173-189.
48. Xu L, Geman D, Winslow RL. (2007). Large-scale integration of cancer microarray data identifies a robust common cancer signature. BMC Bioinform 8: 275.