Identification of the gene encoding cyclin E1 (CCNE1) as a novel IGH translocation partner in t(14;19)(q32;q12) in diffuse large B-cell lymphoma

Haematologica

Volumn 94, Issue 7, 2009, Pages 1020-1023

  Nagel, Inga ^a   Akasaka, Takashi ^b   Klapper, Wolfram ^c   Gesk, Stefan ^a   Böttcher, Sebastian ^c   Ritgen, Matthias ^c   Harder, Lana ^a   Kneba, Michael ^c   Dyer, Martin J S ^b   Siebert, Reiner ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

Cyclin E1; Diffuse large B cell lymphoma; IGH; MYC; Translocation

Indexed keywords

CYCLIN D; CYCLIN E; CYCLIN E1; IMMUNOGLOBULIN HEAVY CHAIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; B CELL LYMPHOMA; CASE REPORT; CCNE1 GENE; CELL CYCLE; CHROMOSOME TRANSLOCATION; CYTOGENETICS; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; GENE LOCUS; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KARYOTYPE; LARGE CELL LYMPHOMA; LEUKEMIA CELL; MALE; ONCOGENE; ONCOGENE MYC; PATHOGENESIS; PROTEIN EXPRESSION;

BASE SEQUENCE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 19; CYCLIN E; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; LYMPHOMA, B-CELL; LYMPHOMA, NON-HODGKIN; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSLOCATION, GENETIC;

EID: 67650712257     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2008.000968     Document Type: Article

References (17)

1. Siebert R, Rosenwald A, Staudt LM, Morris SW. Molecular features of B-cell lymphoma. Curr Opin Oncol 2001;3:316-24.
2. Hummel M, Bentink S, Berger H, Klapper W, Wessendorf S, Barth TF, et al. A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. N Engl J Med 2006;354:2419-30.
3. Lenz G, Nagel I, Siebert R, Roschke AV, Sanger W, Wright GW, et al. Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma. J Exp Med 2007;204:633-43.
4. Gesk S, Klapper W, Martin-Subero JI, Nagel I, Harder L, Fu K, et al. A chromosomal translocation in cyclin D1-negative/cyclin D2-positive mantle cell lymphoma fuses the CCND2 gene to the IGK locus. Blood 2006; 108:1109-10.
5. Sonoki T, Harder L, Horsman DE, Karran L, Taniguchi I, Willis TG, et al. Cyclin D3 is a target gene of t(6;14)(p21.1;q32.3) of mature B-cell malignancies. Blood 2001;98:2837-44.
6. van Dongen JJ, Langerak AW, Bruggemann M, Evans PA, Hummel M, Lavender FL, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003;17:2257-317.
7. Saez B, Martin-Subero JI, Odero MD, Prosper F, Hernandez R, Cigudosa JC, et al. Interphase FISH for the detection of breakpoints in IG loci and chromosomal changes with adverse prognostic impact in multiple myeloma with normal karyotypes. Cancer Genet Cytogenet 2006;167:183-5.
8. Akasaka T, Balasas T, Russell LJ, Sugimoto KJ, Majid A, Walewska R, et al. Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Blood 2007; 109:3451-61.
9. Martin-Subero JI, Ibbotson R, Klapper W, Michaux L, Callet-Bauchu E, Berger F, et al. A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation. Leukemia 2007;21: 1532-44.
10. Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood 2004;103:275-82.
11. Martin-Subero JI, Harder L, Gesk S, Schlegelberger B, Grote W, Martinez-Climent JA, et al. Interphase FISH assays for the detection of translocations with breakpoints in immunoglobulin light chain loci. Int J Cancer 2002;98:470-4.
12. Sonoki T, Willis TG, Oscier DG, Karran EL, Siebert R, Dyer MJ. Rapid amplification of immunoglobulin heavy chain switch (IGHS) translocation breakpoints using long-distance inverse PCR. Leukemia 2004;18: 2026-31.
13. Schraml P, Bucher C, Bissig H, Nocito A, Haas P, Wilber K, et al. Cyclin E overexpression and amplification in human tumours. J Pathol 2003;200: 375-82.
14. Loden M, Stighall M, Nielsen NH, Roos G, Emdin SO, Ostlund H, et al. The cyclin D1 high and cyclin E high subgroups of breast cancer: separate pathways in tumorogenesis based on pattern of genetic aberrations and inactivation of the pRb node. Oncogene 2002;21:4680-90.
15. Hwang HC, Clurman BE. Cyclin E in normal and neoplastic cell cycles. Oncogene 2005;24:2776-86.
16. Tzankov A, Gschwendtner A, Augustin F, Fiegl M, Obermann EC, Dirnhofer S, et al. Diffuse large B-cell lymphoma with overexpression of cyclin E substantiates poor standard treatment response and inferior outcome. Clin Cancer Res 2006;12: 2125-32.
17. Kanda-Akano Y, Nomura K, Fujita Y, Horiike S, Nishida K, Nagai M, et al. Molecular-cytogenetic characterization of non-Hodgkin's lymphoma with double and cryptic translocations of the immunoglobulin heavy chain gene. Leuk Lymphoma 2004; 45:1559-67.