Assessment of the genetic risks of a metallic alloy used in medical implants

Genetics and Molecular Biology

Volumn 34, Issue 1, 2011, Pages 116-121

  Gomes, Cristiano C ^a   Moreira, Leonardo M ^b   Santos, Vanessa J S V ^b   Ramos, Alfeu S ^a   Lyon, Juliana P ^b   Soares, Cristina P ^a   Santos, Fabio V ^b  

^a INSTITUTO DE PESQUISA E DESENVOLVIMENTO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO JOÃO DEL REI   (Brazil)

Author keywords

Biomaterial; Cytotoxicity; Micronucleus; Mutagenicity; Ti 6al 4V

Indexed keywords

TITANIUM;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL FUNCTION; CELL VIABILITY; CHO CELL; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; GENETIC RISK; GENOTOXICITY; METAL EXTRACTION; METAL IMPLANTATION; MICRONUCLEUS TEST; NONHUMAN;

EID: 79851502319     PISSN: 14154757     EISSN: 16784685     Source Type: Journal    
DOI: 10.1590/S1415-47572010005000118     Document Type: Article

References (39)

1. Altamirano-Lozano M, Valverde M, Alvarez-Barrera L, Molina B and Rojas E (1999) Genotoxic studies of vanadium pentoxide (V2O5) in male mice. II. Effects in several mouse tissues. Teratog Carcinog Mutag 19:243-255.
2. Anastassopoulou J (2003) Metal-DNA interactions. J Mol Struct 651-653:19-23.
3. Cadosch D, Chan E, Gautschi OP and Filgueira L (2009) Metal is not inert: Role of metal ions released by biocorrosion in aseptic loosening - Current concepts. J Biomed Mater Res A 91:1252-1262.
4. Chen F and Shi X (2002) Intracellular signal transduction of cells in response to carcinogenic metals. Oncol Hematol 42:105-121.
5. Cirani R, Antonetti M and Migliori L (1995) Vanadium salts induce cytogenetic effects in in vivo treated mice. Mutat Res 343:53-60.
6. Crebelli R, Carta P, Andreoli C, Aru G, Dobrowolny G, Rossi S and Zijno A (2002) Biomonitoring of primary aluminium industry workers: Detection of micronuclei and repairable DNA lesions by alkaline SCGE. Mutat Res 516:63-70.
7. Doherty AT, Howell RT, Ellis LA, Bisbinas I, Learmonth ID, Newson R and Case CP (2001) Increased chromosome translocations and aneuploidy in peripheral blood lymphocytes of patients having revision arthroplasty of the hip. J Bone Joint Surg Br 83:1075-1081.
8. European Food Safety Authority (EFSA) (2004) Opinion of the scientific panel on dietetic products, nutrition and allergies on a request from the Commission related to the tolerable upper intake level of vanadium. J EFSA 33:1-22.
9. Faria AC, Rosa AL, Rodrigues RC and Ribeiro RF (2008) In vitro cytotoxicity of dental alloys and cpTi obtained by casting. Mater Res Part B Appl Biomater 85:504-508.
10. Fenech M (2000) The in vitro micronucleus technique. Mutat Res 455:81-95.
11. Guillamet E, Creus A, Farina M, Sabbioni E, Fortaner S and Marcosa R (2008) DNA-damage induction by eight metal compounds in TK6 human lymphoblastoid cells: Results obtained with the alkaline comet assay. Mutat Res 654:22-28.
12. International Organization for Standardization (2007) Biological evaluation of medical devices - Part 12: Sample preparation and reference materials. ISO, Genève, 17 pp.
13. Kordowiak AM, Klein A, Goc A and Dabro W (2007) Comparison of the effect of VOSO4, Na3VO4 and NaVO3 on proliferation, viability and morphology of H35-19 rat hepatoma cell line. Pol J Pathol 58:51-57.
14. Lankoff A, Banasik A, Duma A, Ochniak E, Lisowska H, Kuszewski T, Gód S and Wojcik A (2006) A comet assay study reveals that aluminum induces DNA damage and inhibits the repair of radiation-induced lesions in human peripheral blood lymphocytes. Toxicol Lett 161:27-36.
15. Léonard A and Gerber GB (1994) Mutagenicity, carcinogenicity and teratogenicity of vanadium compounds. Mutat Res 317:81-88.
16. Lima PD, Leite DS, Vasconcellos MC, Cavalcanti BC, Santos RA, Costa-Lotufo LV, Pessoa C, Moraes MO and Burbano RR (2007) Genotoxic effects of aluminum chloride in cultured human lymphocytes treated in different phases of cell cycle. Food Chem Toxicol 45:1154-1159.
17. Lin CW, Ju CP and Chern-Lin JH (2005) A comparison of the fatigue behavior of cast Ti 7.5Mo with c.p. titanium, Ti-6Al- 4V and Ti-13Nb-13Zr alloys. Biomaterials 26:2899-2907.
18. Long TC, Tajuba J, Sama P, Saleh N, Swartz C, Parker J, Hester S, Lowry GV and Veronesi B (2007) Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro. Environ Health Perspect 115:1631-1637.
19. Lu P, Ho I and Lee T (1998) Induction of sister chromatid exchanges and micronuclei by titanium dioxide in Chinese hamster ovary-K1 cells. Mutat Res 414:15-20.
20. Migliore L, Bocciardi R, Macrì C and Lo Jacono F (1993) Cytogenetic damage induced in human lymphocytes by four vanadium compounds and micronucleus analysis by fluorescence in situ hybridization with a centromeric probe. Mutat Res 319:205-213.
21. Morais LS, Serra GG, Palermo EFA, Andrade LR, Muller CA, MeyersMAand Elias CN (2009) Systemic levels of metallic ions released from orthodontic mini-implants. Am J Orthod Dentofacial Orthop 135:522-529.
22. Okazaki Y and Gotoh E (2005) Comparison of metal release from various metallic biomaterials in vitro. Biomaterials 26:11-21.
23. Okazaki Y, Gotoh E, Manabe T and Kobayashi K (2004) Comparison of metal concentrations in rat tibia tissues with various metallic implants. Biomaterials 25:5913-5920.
24. Owusu-Yaw J, Cohen MD, Fernando SY and Wei CI (1990) An assessment of the genotoxicity of vanadium. Toxicol Lett 50:327-336.
25. Papageorgiou I, Brown C, Schins R, Singh S, Newson R, Davis S, Fisher J, Ingham E and Case CP (2007) The effect of nanoand micron-sized particles of cobalt-chromium alloy on human fibroblasts in vitro. Biomaterials 28:2946-2958.
26. Ramírez P, Eastmond DA, Laclette JP and Ostrosky-Wegman P (1997) Disruption of microtubule assembly and spindle formation as a mechanism for the induction of aneuploid cells by sodium arsenite and vanadium pentoxide. Mutat Res 386:291-298.
27. Reeves JF, Davies SJ, Dodd NJ and Jha AN (2008) Hydroxyl radicals (*OH) are associated with titanium dioxide (TiO2) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells. Mutat Res 640:113-122.
28. Riley MR, Boesewetter DE, Kim AM and Sirvent FP (2003) Effects of metals Cu, Fe, Ni, V, and Zn on rat lung epithelial cells. Toxicology 190:171-184.
29. Sargeant A and Goswami T (2007) Hip implants - Paper VI - Ion concentrations. Mater Des 28:155-171.
30. Scheving LA, Thomas JR and Zhang L (1999) Regulation of intestinal tyrosine phosphorylation and programmed cell death by peroxovanadate. Am J Physiol 277:C572-C579.
31. Sedarat C, Harmand MF, Naji A and Nowzari H (2001) In vitro kinetic evaluation of titanium alloy biodegradation. J Periodont Res 36:269-274.
32. Soares SS, Henao F, AurelianoMand Gutiérrez-Merino C (2008) Vanadate induces necrotic death in neonatal rat cardiomyocytes through mitochondrial membrane depolarization. Chem Res Toxicol 21:607-618.
33. Stea S, Visentin M, Granchi D, Savarino L, Dallari D, Gualtieri G, Rollo G, Toni A, Pizzoferrato A and Montanaro L (2000) Sister chromatid exchange in patients with joint prostheses. J Arthroplasty 15:772-777.
34. Titenko-Holland N, Windham G, Kolachana P, Reinisch F, Parvatham S, Osorio AM and Smith MT (1997) Genotoxicity of malathion in human lymphocytes assessed using the micronucleus assay in vitro and in vivo: A study of malathionexposed workers. Mutat Res 338:85-95.
35. Valko M, Rhodes CJ, Moncol J, Izakovic M and Mazur M (2006) Free radicals, metals and antioxidants in oxidative stressinduced cancer. Chem Biol Interact 160:1-40.
36. Vendittoli PA, Amzica T, Roy AG, Lusignan D, Girard J and Lavigne M (2010) Metal ion release with large-diameter metal-on-metal hip arthroplasty. J Arthroplasty Epub.
37. Wang TS and Huang H (1994) Active oxygen species are involved in the induction of micronuclei by arsenite in XRS-5 cells. Mutagenesis 9:253-257.
38. Ziaee H, Daniel J, Datta AK, Blunt S and McMinn DJ (2007) Transplacental transfer of cobalt and chromium in patients with metal-on-metal hip arthroplasty: A controlled study. J Bone Joint Surg Br 89:301-305.
39. Zreiqat H, Valenzuela SM, Nissan BB, Roest R, Knabe C, Radlanski RJ, Renz H and Evans PJ (2005) The effect of surface chemistry modification of titanium alloy on signaling pathways in human osteoblasts. Biomaterials 26:7579-7586.