Genotoxic effects of aluminum chloride in cultured human lymphocytes treated in different phases of cell cycle

Food and Chemical Toxicology

Volumn 45, Issue 7, 2007, Pages 1154-1159

  Lima, P D L ^a   Leite, D S ^a   Vasconcellos, M C ^b   Cavalcanti, B C ^b   Santos, R A ^c   Costa Lotufo, L V ^b   Pessoa, C ^b   Moraes, M O ^b   Burbano, R R ^a  

^a Department of Biology   (Brazil)

^b FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Aluminum chloride; Chromosome aberration; Comet assay

Indexed keywords

ALUMINUM CHLORIDE;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; GENOTOXICITY; HUMAN; HUMAN CELL; INTERPHASE; LYMPHOCYTE CULTURE; MITOSIS INDEX; MUTAGENICITY; POLYPLOIDY;

ALUMINUM COMPOUNDS; ANEUGENS; CELL CYCLE; CELL SURVIVAL; CELLS, CULTURED; CHLORIDES; CHROMOSOME ABERRATIONS; COMET ASSAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; HUMANS; LYMPHOCYTES; POLYPLOIDY;

EID: 34247176224     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2006.12.022     Document Type: Article

References (49)

1. Altschuler E. Aluminum-containing antacids as a cause of idiopathic Parkinson's disease. Med. Hypotheses 53 (1999) 22-23
2. Amorim M.I.M., Mergler D., Bahia M.O., Dubeau H., Miranda D., Lebel J., Burbano R.R., and Lucotte M. Cytogenetic damage related to low levels of methyl mercury contamination in the Brazilian Amazon. An. Acad. Bras. Cienc. 72 (2000) 497-507
3. Atterwill C.K., Johnston H., and Thomas S.M. Models for the in vitro assessment of neurotoxicity in the nervous system in relation to xenobiotic an neurotrophic factor-mediates events. Neurotoxicology 13 1 (1992) 39-53
4. Ayres M., Ayres Jr. M., Ayres D.L., and Santos A.S. Bioestat 2.0. Belém (2000), Sociedade Civil Mamirauá p. 272
5. Bahia M.d.O., Corvelo T.C., Mergler D., Burbano R.R., Lima P.D., Cardoso P.C., Lucotte M., and Amorim M.I. Environmental biomonitoring using cytogenetic endpoints in a population exposed to mercury in the Brazilian Amazon. Environ. Mol. Mutagen. 44 4 (2004) 346-349
6. Becaria A., Campbell A., and Bondy S.C. Aluminum as a toxicant. Toxicol. Ind. Health 18 7 (2002) 309-320
7. Bentes, R., 1992. Um novo estilo de ocupação econômica da Amazônia: os grandes projetos. In: Freire, G., Freire, A.R.C. (Eds.), Estudo e Problemas Amazônicos - História Social e Econômica e Temas Especiais. Belém, CEJUP, pp. 89-113.
8. Berthon G. Chemical speciation studies in relation to aluminium metabolism and toxicity. Coord. Chem. Rev. 149 (1996) 241-280
9. Bjorkstein J., Yaeger L.L., and Wallace T. Control of aluminium ingestion and its relation to longevity. Int. J. Vitam. Nutr. Res. 58 4 (1988) 462-465
10. Botchway S.W., Stevens D.L., Hill M.A., Jenner T.J., and O'Neill P. Induction and rejoining of DNA double-strand breaks in Chinese hamster V79-4 cells irradiated with characteristic aluminum K and copper L ultrasoft X rays. Radiat. Res. 148 4 (1997) 317-324
11. Brogger A. The chromatid gap-a useful parameter in genotoxicology?. Cytogenet. Cell Genet. 33 (1982) 14-19
12. Candura S.M., Manzo L., and Costa L.G. Role of occupational neurotoxicants in psychiatric and neurodegenerative disorders. In: Costa L.G., and Manzo L. (Eds). Occupational Neurotoxicology (1998), CRC Press, Boca Raton 131-167
13. Corain B., Bombi G.G., Tapparo A., Perazzolo M., and Zatta P. Aluminium toxicity and metal speciation: established data and open questions. Coord. Chem. Rev. 149 (1996) 11-22
14. Dhawan A., Kayani M.A., Parry J.M., Parry E., and Anderson D. Aneugenic and clastogenic effects of doxorubicin in human lymphocytes. Mutagenesis 18 (2003) 487-490
15. Dovgaliuk A.I., Kaliniak T.B., and Blium I.B. Assessment of phyto- and cytotoxic effects of heavy metals and aluminum compounds using onion apical root meristem. Tsitol. Genet. 35 1 (2001) 3-9
16. Dovgaliuk A.I., Kaliniak T.B., and Blium I.B. Cytogenetic effects of toxic metal salts on apical meristem cells of Allium cepa L. seed roots. Tsitol. Genet. 35 2 (2001) 3-10
17. Elmore A.R. Final report on the safety assessment of aluminum silicate, calcium silicate, magnesium aluminum silicate, magnesium silicate, magnesium trisilicate, sodium magnesium silicate, zirconium silicate, attapulgite, bentonite, Fuller's earth, hectorite, kaolin, lithium magnesium silicate, lithium magnesium sodium silicate, montmorillonite, pyrophyllite and zeolite. Int. J. Toxicol. 22 1 (2003) 37-102
18. Fahn S. Parkinsonism. In: Rowland L.P. (Ed). Merrit's Textbook of Neurology. Media (1995), P.A. Williams & Wilkins 713-730
19. Ferrer A. Metal poisoning. An. Sist. Sanit. Navar. 26 (2003) 141-153
20. Ganrot P.O. Metabolism and possible health effects of aluminum. Environ. Health Persp. 65 (1986) 363-441
21. Gontijo A.M.M.C., and Tice R. Teste do cometa para a detecção de dano no DNA e reparo em células individualizadas. In: Ribeiro L.R., Salvadori D.M.F., and Marques E.K. (Eds). Mutagênese Ambiental (2003), ULBRA Inc., Canoas 247-275
22. Hartmann A., and Speit G. The contribution of cytotoxicity to DNA-effects in the single cell gel test (comet assay). Toxicol. Lett. 90 (1997) 183-188
23. Kopac I., Batista U., Cvetko E., and Marion L. Viability of fibroblasts in cell culture after treatment with different chemical retraction agents. J. Oral. Rehabil. 29 1 (2002) 98-104
24. Moorhead P.S., Nomell P.C., Mellman W.J., Battips D.M., and Hungerford D.A. Chromosome preparations of leucocytes cultured from human peripheral blood. Exp. Cell. Res. 20 (1960) 613-616
25. Moreno E.A., Rojas G.F., Frenk F.H., De La Huerta A.O., Belmares R.Q., and Vargas A.R.O. In vitro induction of abnormal anaphases by contaminating atmospheric dust from the City of Mexicali, Baja California, Mexico. Arch. Med. Res. 28 4 (1997) 549-553
26. Pagano G., His E., Beiras R., De Biase A., Korkina L.G., Iaccarino M., Oral R., Quiniou F., Warnau M., and Trieff N.M. Cytogenetic, developmental, and biochemical effects of aluminum, iron, and their mixture in sea urchins and mussels. Arch. Environ. Contam. Toxicol. 31 4 (1996) 466-474
27. Paz-y-Mino C., Davalos M.V., Sanchez M.E., Arevalo M., and Leone P.E. Should gaps be included in chromosomal aberration analysis? Evidence based on the comet assay. Mutat. Res. 516 (2002) 57-61
28. Preston R.J., San Sebastian J.R., and McFee A.F. The in vitro human lymphocyte assay for assessing the clastogenicity of chemical agents. Mutat. Res. 189 2 (1987) 175-183
29. Reinhardt C.A., Pelli D.A., and Sandvold M. Cell detachment and growth of fibroblasts as parameters for cytotoxicity of inorganic metal salts in vitro. Cell Biol. Toxicol. 1 2 (1985) 33-43
30. Reinke C.M., Breitkreutz J., and Leuenberger H. Aluminium in over-the-counter drugs: risks outweigh benefits?. Drug Safety 26 14 (2003) 1011-1025
31. Schinzel A., and Schmid W. Lymphocyte chromosome studies in humans exposed to chemical mutagens. The validity of the method in 67 patients under cytostatic therapy. Mutat. Res. 40 (1976) 139-166
32. Silva-Pereira L.C., Cardoso P.C., Leite D.S., Bahia M.O., Bastos W.R., Smith M.A., and Burbano R.R. Cytotoxicity and genotoxicity of low doses of mercury chloride and methylmercury chloride on human lymphocytes in vitro. Braz. J. Med. Biol. Res. 38 6 (2005) 901-907
33. Singh N.P., Mccoy M.T., Tice R.R., and Schneider E.L.A. Single technique for quantitation of low levels of DNA damage in indiidual cells. Exp. Cell Res. 175 (1988) 184-191
34. Smith R.W. Kinetic aspects of aqueous aluminum chemistry: environmental implications. Coord. Chem. Rev. 149 (1996) 81-93
35. Sorenson J.R., Campbell I.R., Tepper L.B., and Lingg R.D. Aluminum in the environment and human health. Environ. Health Persp. 8 (1974) 3-95
36. Speit G., and Hartmann A. The comet assay (single-cell gel test). A sensitive genotoxicity test for the detection of DNA damage and repair. Meth. Mol. Biol. 113 (1999) 203-212
37. 3 on toad skin, human erythrocytes, and model cell membranes. Brain Res. Bull. 55 (2001) 205-210
38. Synzynys B.I., Sharetskii A.N., and Kharlamova O.V. Immunotoxicity of aluminum chloride. Gig. Sanit. 4 (2004) 70-72
39. Toimela T., and Tahti H. Mitochondrial viability and apoptosis induced by aluminum, mercuric mercury and methylmercury in cell lines of neural origin. Arch. Toxicol. 78 10 (2004) 549-564
40. Toimela T., Maenpaa H., Mannerstrom M., and Tahti H. Development of an in vitro blood-brain barrier model-cytotoxicity of mercury and aluminum. Toxicol. Appl. Pharmacol. 195 1 (2004) 73-82
41. Trippi F., Botto N., Scarpato R., Petrozzi L., Bonuccelli U., Latorraca S., Sorbi S., and Migliore L. Spontaneous and induced chromosome damage in somatic cells of sporadic and familial Alzheimer's disease patients. Mutagenesis 16 (2001) 323-327
42. Varella S.D., Pozetti G.L., Vilegas W., and Varanda E.A. Mutagenic activity in waste from an aluminum products factory in Salmonella/microsome assay. Toxicol. In Vitro 18 (2004) 895-900
43. Veldman B.A., Widn A.M., Knoers N., Pramstra P., and Horstink M.W. Genetic and environmental risk factors in Parkinson's disease. J. Neuro. Chem. 71 (1998) 295-301
44. Wagner E.D., Anderson D., Dhawan A., Rayburn A.L., and Plewa M.J. Evaluation of EMS-induced dna damage in the single cell gel electrophoresis (Comet) assay and with flow cytometric analysis of micronuclei. Teratogen. Carcin. Mut. Suppl. 2 (2003) 1-11
45. Williams R.J.P. Aluminium and biological systems: an introduction. Coord. Chem. Rev. 149 (1996) 1-9
46. Yasui M., Kihira T., and Ota K. Calcium, magnesium and aluminum concentrations in Parkinson's disease. Neurotoxicology 13 (1992) 593-600
47. Yokel R.A. Brain uptake, retention, and efflux of aluminum and manganese. Environ. Health Persp. 110 (2002) 699-704
48. Yumei W., Jinfeng J., Xiaohong Z., and Baoshan Y. Genotoxicity of the dust organic extract and its fractions derived from an aluminium electrolytic plant. Toxicol. Lett. 98 3 (1998) 147-153
49. Zhang K., and Zhou Q. Toxic effects of Al-based coagulants on Brassica chinensis and Raphanus sativus growing in acid and neutral conditions. Environ. Toxicol. 20 (2005) 179-187