Functional quorum sensing systems are maintained during chronic Burkholderia cepacia complex infections in patients with cystic fibrosis

Journal of Infectious Diseases

Volumn 203, Issue 3, 2011, Pages 383-392

  McKeon, Suzanne A ^a   Nguyen, David T ^a   Viteri, Duber F ^a   Zlosnik, James E A ^b   Sokol, Pamela A ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

N ACYLHOMOSERINE LACTONE;

ADULT; ARTICLE; BACTERIAL GROWTH; BACTERIAL MUTATION; BACTERIAL STRAIN; BACTERIUM ISOLATE; BURKHOLDERIA; BURKHOLDERIA CENOCEPACIA; BURKHOLDERIA CEPACIA INFECTION; BURKHOLDERIA MULTIVORANS; CONTROLLED STUDY; CYSTIC FIBROSIS; EVOLUTIONARY ADAPTATION; HUMAN; MICROBIAL ACTIVITY; NONHUMAN; PRIORITY JOURNAL; QUORUM SENSING; STRAIN DIFFERENCE; WILD TYPE;

ACYL-BUTYROLACTONES; BURKHOLDERIA CEPACIA COMPLEX; BURKHOLDERIA INFECTIONS; CYSTIC FIBROSIS; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MUTATION; QUORUM SENSING;

EID: 79751516462     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jiq054     Document Type: Article

References (49)

1. Dupuis A, Hamilton D, Cole DE, Corey M. Cystic fibrosis birth rates in Canada: A decreasing trend since the onset of genetic testing. J Pediatr 2005; 147:312-5. (Pubitemid 41345759)
2. Jacquot J, Tabary O, Le Rouzic P, Clement A. Airway epithelial cell inflammatory signalling in cystic fibrosis. Int J Biochem Cell Biol 2008; 40:1703-15.
3. Coenye T, Vandamme P, Govan JR, LiPuma JJ. Taxonomy and identification of the Burkholderia cepacia complex. J Clin Microbiol 2001; 39:3427-36. (Pubitemid 32954480)
4. Mahenthiralingam E, Baldwin A, Dowson CG. Burkholderia cepacia complex bacteria: Opportunistic pathogens with important natural biology. J Appl Microbiol 2008; 104:1539-51. (Pubitemid 351724983)
5. Vanlaere E, Lipuma JJ, Baldwin A, et al. Burkholderia latens sp. nov., Burkholderia diffusa sp. nov., Burkholderia arboris sp. nov., Burkholderia seminalis sp. nov., Burkholderia metallica sp. nov., novel species within the Burkholderia cepacia complex. Int J Syst Evol Microbiol 2008; 58:1580-90.
6. Vanlaere E, Baldwin A, Gevers D, et al. Taxon K, a complex within the Burkholderia cepacia complex, comprises at least two novel species, Burkholderia contaminans sp. nov. Burkholderia lata sp. nov. Int J Syst Evol Microbiol 2009; 59:102-11.
7. Vandamme P, Holmes B, Coenye T, et al. Burkholderia cenocepacia sp. nov.-a new twist to an old story. Res Microbiol 2003; 154: 91-6. (Pubitemid 36324500)
8. Reik R, Spilker T, Lipuma JJ. Distribution of Burkholderia cepacia complex species among isolates recovered from persons with or without cystic fibrosis. J Clin Microbiol 2005; 43:2926-8. (Pubitemid 40827976)
9. Govan JR, Brown AR, Jones AM. Evolving epidemiology of Pseudomonas aeruginosa and the Burkholderia cepacia complex in cystic fibrosis lung infection. Future Microbiol 2007; 2:153-64. (Pubitemid 46766989)
10. Mahenthiralingam E, Urban TA, Goldberg JB. The multifarious, multireplicon Burkholderia cepacia complex. Nat Rev Microbiol 2005; 3:144-56. (Pubitemid 40207595)
11. Sokol PA, Malott RJ, Riedel K, Eberl L. Communication systems in the genus Burkholderia: Global regulators and targets for novel antipathogenic drugs. Future Microbiol 2007; 2:555-63. (Pubitemid 47578217)
12. Malott RJ, O'Grady EP, Toller J, Inhulsen S, Eberl L, Sokol PA. A Burkholderia cenocepacia orphan LuxR homolog is involved in quorum-sensing regulation. J Bacteriol 2009; 191:2447-60.
13. Baldwin A, Sokol PA, Parkhill J, Mahenthiralingam E. The Burkholderia cepacia epidemic strain marker is part of a novel genomic island encoding both virulence and metabolism-associated genes in Burkholderia cenocepacia. Infect Immun 2004; 72:1537-47. (Pubitemid 38263776)
14. Lewenza S, Sokol PA. Regulation of ornibactin biosynthesis and Nacyl-L-homoserine lactone production by CepR in Burkholderia cepacia. J Bacteriol 2001; 183:2212-8. (Pubitemid 32240389)
15. Subsin B, Chambers CE, Visser MB, Sokol PA. Identification of genes regulated by the cepIR quorum-sensing system in Burkholderia cenocepacia by high-throughput screening of a random promoter library. J Bacteriol 2007; 189:968-79. (Pubitemid 46183872)
16. O'Grady EP, Viteri DF, Malott RJ, Sokol PA. Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia. MC Genomics 2009; 10:441.
17. Kothe M, Antl M, Huber B, et al. Killing of Caenorhabditis elegans by Burkholderia cepacia is controlled by the cep quorum-sensing system. Cell Microbiol 2003; 5:343-51. (Pubitemid 37009911)
18. Sokol PA, Sajjan U, Visser MB, Gingues S, Forstner J, Kooi C. The CepIR quorum-sensing system contributes to the virulence of Burkholderia cenocepacia respiratory infections. Microbiology 2003; 149:3649-58. (Pubitemid 38016691)
19. Huber B, Feldmann F, Kothe M, et al. Identification of a novel virulence factor in Burkholderia cenocepacia H111 required for efficient slow killing of Caenorhabditis elegans. Infect Immun 2004; 72:7220-30. (Pubitemid 39552393)
20. Sousa SA, Ulrich M, Bragonzi A, et al. Virulence of Burkholderia cepacia complex strains in gp91phox-/- mice. Cell Microbiol 2007; 9:2817-25. (Pubitemid 350066567)
21. Uehlinger S, Schwager S, Bernier SP, et al. Identification of specific and universal virulence factors in Burkholderia cenocepacia strains by using multiple infection hosts. Infect Immun 2009; 77:4102-10.
22. Lutter E, Lewenza S, Dennis JJ, Visser MB, Sokol PA. Distribution of quorum-sensing genes in the Burkholderia cepacia complex. Infect Immun 2001; 69:4661-6. (Pubitemid 32574469)
23. Smith EE, Buckley DG, Wu Z, et al. Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proc Natl Acad Sci U S A 2006; 103:8487-92. (Pubitemid 43838482)
24. Wilder CN, Allada G, Schuster M. Instantaneous within-patient diversity of Pseudomonas aeruginosa quorum-sensing populations from cystic fibrosis lung infections. Infect Immun 2009; 77:5631-9.
25. Hoffman LR, Kulasekara HD, Emerson J, et al. Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression. J Cyst Fibros 2009; 8:66-70.
26. Schuster M, Lostroh CP, Ogi T, Greenberg EP. Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: A transcriptome analysis. J Bacteriol 2003; 185:2066-79. (Pubitemid 36363167)
27. Heurlier K, Denervaud V, Haas D. Impact of quorum sensing on fitness of Pseudomonas aeruginosa. Int J Med Microbiol 2006; 296:93-102. (Pubitemid 43375991)
28. Diggle SP, Griffin AS, Campbell GS, West SA. Cooperation and conflict in quorum-sensing bacterial populations. Nature 2007; 450:411-4. (Pubitemid 350126749)
29. Sandoz KM, Mitzimberg SM, Schuster M. Social cheating in Pseudomonas aeruginosa quorum sensing. Proc Natl Acad Sci U S A 2007; 104:15876-81. (Pubitemid 350035392)
30. Rumbaugh KP, Diggle SP, Watters CM, Ross-Gillespie A. Griffin AS West SA. Quorum sensing and the social evolution of bacterial virulence. Curr Biol 2009; 19:341-5.
31. Mahenthiralingam E, Coenye T, Chung JW, et al. Diagnostically experimentally useful panel of strains from the Burkholderia cepacia complex. J Clin Microbiol 2000; 38:910-3. (Pubitemid 30082711)
32. Malott RJ, Baldwin A, Mahenthiralingam E, Sokol PA. Characterization of the cciIR quorum-sensing system in Burkholderia cenocepacia. Infect Immun 2005; 73:4982-92. (Pubitemid 41105656)
33. Miller VL, Mekalanos JJ. A novel suicide vector its use in construction of insertion mutations: Osmoregulation of outer membrane proteins and virulence determinants in Vibrio cholerae requires toxR. J Bacteriol 1988; 170:2575-83.
34. Flannagan RS, Linn T, Valvano MA. A system for the construction of targeted unmarked gene deletions in the genus Burkholderia. Environ Microbiol 2008; 10:1652-60. (Pubitemid 351670258)
35. Hoang TT, Karkhoff-Schweizer RR, Kutchma AJ, Schweizer HP. A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: Application for isolation of unmarked Pseudomonas aeruginosa mutants. Gene 1998; 212:77-86. (Pubitemid 28269135)
36. Palmer KL, Aye LM, Whiteley M. Nutritional cues control Pseudomonas aeruginosa multicellular behavior in cystic fibrosis sputum. J Bacteriol 2007; 189:8079-87. (Pubitemid 350178919)
37. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: A laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989.
38. Dennis JJ, Sokol PA. Electrotransformation of Pseudomonas. Methods Mol Biol 1995; 47:125-33.
39. Bernier SP, Beeston AL, Sokol PA. Detection of N-acyl homoserine lactones using a traI-luxCDABE-based biosensor as a high-throughput screening tool. BMC Biotechnol 2008; 8:59.
40. Chambers CE, Visser MB, Schwab U, Sokol PA. Identification of N-acylhomoserine lactones in mucopurulent respiratory secretions from cystic fibrosis patients. FEMS Microbiol Lett 2005; 244:297-304. (Pubitemid 40342842)
41. Cash HA, Woods DE, McCullough B, Johanson WG Jr, Bass JA. A rat model of chronic respiratory infection with Pseudomonas aeruginosa. Am Rev Respir Dis 1979; 119:453-9. (Pubitemid 9131392)
42. Holden MT, Seth-Smith HM, Crossman LC, et al. The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients. J Bacteriol 2009; 191:261-77.
43. Bjarnsholt T, Jensen PO, Jakobsen TH, et al. Quorum sensing virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients. PLoS One 2010; 5:e10115.
44. Conway BA, Chu KK, Bylund J, Altman E, Speert DP. Production of exopolysaccharide by Burkholderia cenocepacia results in altered cell-surface interactions and altered bacterial clearance in mice. J Infect Dis 2004; 190:957-66. (Pubitemid 39120973)
45. Zlosnik JAE, Costa PS, Brant R, et al. Mucoid and nonmucoid Burkholderia cepacia complex bacteria in cystic fibrosis infections. Am J Respir Crit Care Med Epub ahead of print Aug 13, 2010, doi:10.1164/rccm.201002-0203OC.
46. Drevinek P, Holden MT, Ge Z, et al. Gene expression changes linked to antimicrobial resistance, oxidative stress, iron depletion retained motility are observed when Burkholderia cenocepacia grows in cystic fibrosis sputum. BMC Infect Dis 2008; 8:121.
47. Heurlier K, Denervaud V, Haenni M, Guy L, Krishnapillai V, Haas D. Quorum-sensing-negative (lasR) mutants of Pseudomonas aeruginosa avoid cell lysis and death. J Bacteriol 2005; 187:4875-83. (Pubitemid 40962204)
48. D'Argenio DA, Wu M, Hoffman LR, et al. Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients. Mol Microbiol 2007; 64:512-33. (Pubitemid 46632635)
49. Dekimpe V, Deziel E. Revisiting the quorum-sensing hierarchy in Pseudomonas aeruginosa: The transcriptional regulator RhlR regulates LasR-specific factors. Microbiology 2009; 155:712-23.