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Volumn 25, Issue 1, 2011, Pages 7-15

Tackling the challenges of clinical trials in palliative care

Author keywords

Clinical trial design; Data collection; Ethics; Palliative care; Quality of life; Research and development

Indexed keywords

ADVERSE OUTCOME; CLINICAL PRACTICE; CLINICAL RESEARCH; CONTROLLED CLINICAL TRIAL (TOPIC); ETHICS; HEALTH CARE QUALITY; HUMAN; INFORMATION PROCESSING; PALLIATIVE THERAPY; PATIENT REFERRAL; PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW;

EID: 79751511081     PISSN: 11782595     EISSN: 11791993     Source Type: Journal    
DOI: 10.2165/11539790-000000000-00000     Document Type: Review
Times cited : (11)

References (42)
  • 2
    • 0002040327 scopus 로고    scopus 로고
    • Palliative care history: A ritual process?
    • Clark D. Palliative care history: a ritual process? Eur J Cancer Care 2000; 7 (2): 50-4
    • (2000) Eur J Cancer Care , vol.7 , Issue.2 , pp. 50-54
    • Clark, D.1
  • 3
    • 34247269809 scopus 로고    scopus 로고
    • From margins to centre: A review of the history of palliative care in cancer
    • DOI 10.1016/S1470-2045(07)70138-9, PII S1470204507701389
    • Clark D. Palliative care history: a ritual process? Eur J Cancer Care 2000; 7 (2): 50-4 (Pubitemid 46621771)
    • (2007) Lancet Oncology , vol.8 , Issue.5 , pp. 430-438
    • Clark, D.1
  • 4
    • 34247215347 scopus 로고    scopus 로고
    • Palliativemedicine: Thefirst 18 yearsofanewsubspecialityofgeneral medicine
    • Doyle D. Palliativemedicine: thefirst 18 yearsofanewsubspecialityofgeneral medicine. J R Coll Physicians Edinb 2005; 35: 199-205
    • (2005) J R Coll Physicians Edinb , vol.35 , pp. 199-205
    • Doyle, D.1
  • 6
    • 77950478147 scopus 로고    scopus 로고
    • Trajectories ofdisability in the last year of life
    • Gill TM, Gahbauer EA, Han L, et al. Trajectories ofdisability in the last year of life. N Engl J Med 2010; 362 (13): 1173-80
    • (2010) N Engl J Med , vol.362 , Issue.13 , pp. 1173-1180
    • Gill, T.M.1    Gahbauer, E.A.2    Han, L.3
  • 7
    • 31344445894 scopus 로고    scopus 로고
    • A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease
    • DOI 10.1016/j.jpainsymman.2005.06.007, PII S0885392405005610
    • Solano J, Gomes B, Higginson I. A comparison ofsymptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. J Pain Symptom Manage 2006; 31: 58-69 (Pubitemid 43143299)
    • (2006) Journal of Pain and Symptom Management , vol.31 , Issue.1 , pp. 58-69
    • Solano, J.P.1    Gomes, B.2    Higginson, I.J.3
  • 8
    • 77954437472 scopus 로고    scopus 로고
    • Why don't we do more rigorous clinical research so that we can stop experimenting on patients?
    • Currow DC Why don't we do more rigorous clinical research so that we can stop experimenting on patients? J Pall Med 2010; 13 (6): 636-7
    • (2010) J Pall Med , vol.13 , Issue.6 , pp. 636-637
    • Currow, D.C.1
  • 9
    • 65349126371 scopus 로고    scopus 로고
    • Prescribing at times of clinical transition in chronic or progressive diseases
    • Currow DC, To THM, Abernethy AP. Prescribing at times of clinical transition in chronic or progressive diseases. Int J Gerontology 2009; 3 (1): 1-8
    • (2009) Int J Gerontology , vol.3 , Issue.1 , pp. 1-8
    • Currow, D.C.1    Thm, T.2    Abernethy, A.P.3
  • 11
    • 55549120207 scopus 로고    scopus 로고
    • A survey of the views of palliative care healthcare professionals towards referring cancer patients to participate in randomized controlled trials in palliative care
    • Dec
    • White C, Gilshenan K, Hardy J. A survey of the views of palliative care healthcare professionals towards referring cancer patients to participate in randomized controlled trials in palliative care. Support Care Cancer 2008 Dec; 16 (12): 1397-405
    • (2008) Support Care Cancer , vol.16 , Issue.12 , pp. 1397-1405
    • White, C.1    Gilshenan, K.2    Hardy, J.3
  • 12
    • 77956457272 scopus 로고    scopus 로고
    • What do palliative care patients and their relatives think about research in palliative care? A systematic review
    • White C, Hardy J. What do palliative care patients and their relatives think about research in palliative care? A systematic review. Support Care Cancer 2010; 18 (8) 905-11
    • (2010) Support Care Cancer , vol.18 , Issue.8 , pp. 905-911
    • White, C.1    Hardy, J.2
  • 13
    • 0034669456 scopus 로고    scopus 로고
    • Factors considered important at the end of life by patients, family, physicians, and other care providers
    • Nov 15
    • Steinhauser KE, Christakis NA, Clipp EC, et al. Factors considered important at the end of life by patients, family, physicians, and other care providers. JAMA 2000 Nov 15; 284 (19): 2476-82
    • (2000) JAMA , vol.284 , Issue.19 , pp. 2476-2482
    • Steinhauser, K.E.1    Christakis, N.A.2    Clipp, E.C.3
  • 14
    • 77951782261 scopus 로고    scopus 로고
    • A narrative review of the published ethical debates in palliative care research and an assessment of their adequacy to inform re-search governance
    • Duke S, Bennett H. A narrative review of the published ethical debates in palliative care research and an assessment of their adequacy to inform re-search governance. Palliat Med 2010; 24 (2): 111-26
    • (2010) Palliat Med , vol.24 , Issue.2 , pp. 111-126
    • Duke, S.1    Bennett, H.2
  • 15
    • 84912145224 scopus 로고    scopus 로고
    • Cicely Saunders: Founder of the Hospice Movement. Selected letters 1959-1999 [book review]
    • Mar
    • Carter R. Cicely Saunders: founder of the Hospice Movement. Selected letters 1959-1999 [book review]. J R Soc Med 2003 Mar; 96 (3): 149-51
    • (2003) J R Soc Med , vol.96 , Issue.3 , pp. 149-151
    • Carter, R.1
  • 16
    • 57449115139 scopus 로고    scopus 로고
    • Changes in the quantity and level ofevidence ofpalliative and hospice care literature: The last century
    • Tieman J, Sladek R, Currow DC Changes in the quantity and level ofevidence ofpalliative and hospice care literature: the last century. J Clin Oncol 2008; 26 (35): 5679-83
    • (2008) J Clin Oncol , vol.26 , Issue.35 , pp. 5679-5683
    • Tieman, J.1    Sladek, R.2    Currow, D.C.3
  • 17
    • 0028032438 scopus 로고
    • Evaluation of a palliative care service: Problems and pitfalls
    • Mc Whinney IR, Bass MJ, Donner A. Evaluation of a palliative care service: problems and pitfalls. Br Med J 1994 Nov 19; 309 (6965): 1340-2 (Pubitemid 24345974)
    • (1994) British Medical Journal , vol.309 , Issue.6965 , pp. 1340-1342
    • McWhinney, I.R.1    Bass, M.J.2    Donner, A.3
  • 18
    • 26444516497 scopus 로고    scopus 로고
    • Challeging the framework for evidence in palliative care research
    • DOI 10.1191/0269216305pm1057oa
    • Aoun SM, Kristjanson LJ. Challenging the framework for evidence in palliative care research. Palliat Med 2005 Sep; 19 (6): 461-5 (Pubitemid 41430819)
    • (2005) Palliative Medicine , vol.19 , Issue.6 , pp. 461-465
    • Aoun, S.M.1    Kristjanson, L.J.2
  • 19
    • 34250621200 scopus 로고    scopus 로고
    • National Health and Medical Research Council Available from URL [Accessed 2010 Jun 29]
    • National Health and Medical Research Council. National statement on ethical conduct in human research [online]. Available from URL: http://www. nhmrc.gov.au/publications/ethics/2007-humans/contents.htm [Accessed 2010 Jun 29]
    • National Statement on Ethical Conduct in Human Research [Online]
  • 22
    • 60549110691 scopus 로고    scopus 로고
    • A pilot phase II randomized, cross-over, double-blinded, controlled efficacy study of octreotide versus hyoscine hy-drobromide for control of noisy breathing at the end-of-life
    • Clark K, Currow DC, Agar M, et al. A pilot phase II randomized, cross-over, double-blinded, controlled efficacy study of octreotide versus hyoscine hy-drobromide for control of noisy breathing at the end-of-life. J Pain Palliat Care Pharmacother 2008; 22 (2): 131-8
    • (2008) J Pain Palliat Care Pharmacother , vol.22 , Issue.2 , pp. 131-138
    • Clark, K.1    Currow, D.C.2    Agar, M.3
  • 23
    • 35949003587 scopus 로고    scopus 로고
    • Palliative care becomes 'uninformed euthanasia' when patients are not offered non-invasive life preserving options
    • Autumn
    • Bach JR. Palliative care becomes 'uninformed euthanasia' when patients are not offered non-invasive life preserving options. J Palliat Care 2007 Autumn; 23 (3): 181-4
    • (2007) J Palliat Care , vol.23 , Issue.3 , pp. 181-184
    • Bach, J.R.1
  • 24
    • 56749175034 scopus 로고    scopus 로고
    • Improving the evidence base in palliative medicine: A moral imperative
    • Keeley PW. Improving the evidence base in palliative medicine: a moral imperative. J Med Ethics 2008; 34 (10): 757-60
    • (2008) J Med Ethics , vol.34 , Issue.10 , pp. 757-760
    • Keeley, P.W.1
  • 25
    • 0035447668 scopus 로고    scopus 로고
    • Prescribing of drugs for use outside their licence in palliative care: Survey of specialists in the United Kingdom
    • Pavis H, Wilcock A. Prescribing ofdrugs for use outside their licence in palliativecare: surveyofspecialistsintheUnited Kingdom. BMJ2001 Sep 1; 323 (7311): 484-5 (Pubitemid 32822286)
    • (2001) British Medical Journal , vol.323 , Issue.7311 , pp. 484-485
    • Pavis, H.1    Wilcock, A.2
  • 26
    • 0033519071 scopus 로고    scopus 로고
    • Multicentre randomised controlled trial of nursing intervention for breathlessness in patients with lung cancer
    • Bredin M. Multicentre randomised controlled trial of nursing intervention for breathlessness in patients with lung cancer. Br Med J 1999; 31 (7188): 901-4 (Pubitemid 29191924)
    • (1999) British Medical Journal , vol.318 , Issue.7188 , pp. 901-904
    • Bredin, M.1    Corner, J.2    Krishnasamy, M.3    Plant, H.4    Bailey, C.5    A'Hern, R.6
  • 27
    • 77956359074 scopus 로고    scopus 로고
    • Effect of palliative oxygen versus medical (room) air in relieving breathlessness in patients with refrac-tory dyspnea: A double-blind randomized controlled trial (NCT00327873)
    • Abernethy AP, Mc Donald CF, Frith PA, et al. Effect of palliative oxygen versus medical (room) air in relieving breathlessness in patients with refrac-tory dyspnea: a double-blind randomized controlled trial (NCT00327873). Lancet 2010; 376 (9743): 784-93
    • (2010) Lancet , vol.376 , Issue.9743 , pp. 784-793
    • Abernethy, A.P.1    Mc Donald, C.F.2    Frith, P.A.3
  • 28
    • 0030017727 scopus 로고    scopus 로고
    • Is there a research paradigm for palliative care?
    • Corner J. Is there a research paradigm for palliative care? Palliat Med 1996; 10 (3): 201-8 (Pubitemid 26234128)
    • (1996) Palliative Medicine , vol.10 , Issue.3 , pp. 201-208
    • Corner, J.1
  • 30
    • 61349112231 scopus 로고    scopus 로고
    • A framework for generalizability in palliative care
    • Currow DC, Wheeler J, Glare P, et al. A framework for generalizability in palliative care. J Pain Symptom Manage 2009; 37: 373-86
    • (2009) J Pain Symptom Manage , vol.37 , pp. 373-386
    • Currow, D.C.1    Wheeler, J.2    Glare, P.3
  • 31
    • 10344262054 scopus 로고    scopus 로고
    • Analysis of missing data in palliative care studies
    • DOI 10.1016/j.jpainsymman.2004.02.026, PII S0885392404003410
    • Palmer J. Analysis ofmissing data in palliative care studies. J Pain Symptom Manage 2004; 286: 612-8 (Pubitemid 39626107)
    • (2004) Journal of Pain and Symptom Management , vol.28 , Issue.6 , pp. 612-618
    • Palmer, J.L.1
  • 33
    • 78449247494 scopus 로고    scopus 로고
    • Planning phase III multi-site clinical trials in palliative care: The role ofconsecutive cohort audits to identify potential participant populations
    • Currow DC, Shelby-James TM, Agar M, et al. Planning phase III multi-site clinical trials in palliative care: the role ofconsecutive cohort audits to identify potential participant populations. Support Care Cancer 2010; 18 (12) 1571-9
    • (2010) Support Care Cancer , vol.18 , Issue.12 , pp. 1571-1579
    • Currow, D.C.1    Shelby-James, T.M.2    Agar, M.3
  • 34
    • 73049109255 scopus 로고    scopus 로고
    • Currow DC How should we conduct and interpret phase III clinical trials in palliative care?
    • Abernethy AP, Clark K, Currow DC How should we conduct and interpret phase III clinical trials in palliative care? J Pain Symptom Manage 2010; 39 (1): E6-8
    • (2010) J Pain Symptom Manage , vol.39 , Issue.1
    • Abernethy, A.P.1    Clark, K.2
  • 35
    • 76749160331 scopus 로고    scopus 로고
    • Currow DC Research in palliative care: Is death always an adverse event?
    • Jan
    • Hardy J, Shelby-James T, Currow DC Research in palliative care: is death always an adverse event? Intern Med J 2010 Jan; 40 (1): 89-90
    • (2010) Intern Med J , vol.40 , Issue.1 , pp. 89-90
    • Hardy, J.1    Shelby-James, T.2
  • 36
    • 77954072048 scopus 로고    scopus 로고
    • Enhancing enrollment in palliative care trials: Key insights from a randomized, placebo-controlled study
    • Abernethy AP, Currow DC, Wurzelmann J, et al. Enhancing enrollment in palliative care trials: key insights from a randomized, placebo-controlled study. J Support Oncol 2010; 8 (3): 139-44
    • (2010) J Support Oncol , vol.8 , Issue.3 , pp. 139-144
    • Abernethy, A.P.1    Currow, D.C.2    Wurzelmann, J.3
  • 37
    • 61349201713 scopus 로고    scopus 로고
    • Using national health policies to improve access to palliative care medications in the community
    • Rowett D, Ravenscroft PJ, Hardy J, et al. Using national health policies to improve access to palliative care medications in the community. J Pain Symptom Manage 2009; 37 (3): 395-402
    • (2009) J Pain Symptom Manage , vol.37 , Issue.3 , pp. 395-402
    • Rowett, D.1    Ravenscroft, P.J.2    Hardy, J.3
  • 38
    • 84898689726 scopus 로고    scopus 로고
    • CONSORT Available from URL [Accessed 2010 Oct 7]
    • CONSORT. The CONSORT Statement [online]. Available from URL: http://www.consort-statement.org/consort-statement [Accessed 2010 Oct 7]
    • The CONSORT Statement [Online]
  • 39
  • 40
    • 65349172705 scopus 로고    scopus 로고
    • Currow DC Measuring impacts of value to patients is crucial when evaluating palliative care
    • Mc Caffrey N, Eckermann S, Currow DC Measuring impacts of value to patients is crucial when evaluating palliative care. J Pain Symptom Manage 2009; 37 (6): 7-9
    • (2009) J Pain Symptom Manage , vol.37 , Issue.6 , pp. 7-9
    • Mc Caffrey, N.1    Eckermann, S.2
  • 41
    • 40449088391 scopus 로고    scopus 로고
    • Multi-site research allows adequately powered palliative care trials; web-based data management makes it achievable today [2]
    • DOI 10.1177/0269216307085083
    • Currow DC, Agar M, Tieman J, et al. Multisite research allows adequately powered palliative care trials: web-based data management makes it achiev-able today. Pall Med 2008; 22 (1): 91-2 (Pubitemid 351351376)
    • (2008) Palliative Medicine , vol.22 , Issue.1 , pp. 91-92
    • Currow, D.C.1    Agar, M.2    Tieman, J.3    Abernethy, A.P.4
  • 42
    • 71049121008 scopus 로고    scopus 로고
    • Prioritising drugs for single patient (n-of-1) trials in palliative care
    • Nikles J, Mitchell G, Walters J, et al. Prioritising drugs for single patient (n-of-1) trials in palliative care. Palliat Med 2009; 23 (7): 623-34
    • (2009) Palliat Med , vol.23 , Issue.7 , pp. 623-634
    • Nikles, J.1    Mitchell, G.2    Walters, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.