Effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea: A double-blind, randomised controlled trial

The Lancet

Volumn 376, Issue 9743, 2010, Pages 784-793

  Abernethy, Amy P ^a,b,c   McDonald, Christine F ^d   Frith, Peter A ^c   Clark, Katherine ^e   Herndon II, James E ^a   Marcello, Jennifer ^a   Young, Iven H ^f   Bull, Janet ^g   Wilcock, Andrew ^h   Booth, Sara ⁱ   Wheeler, Jane L ^a   Tulsky, James A ^a,j   Crockett, Alan J ^k   Currow, David C ^b,c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b FLINDERS UNIVERSITY   (Australia)

^c REPATRIATION GENERAL HOSPITAL   (Australia)

^d AUSTIN HEALTH   (Australia)

^e UNIVERSITY OF NOTRE DAME   (Australia)

^f UNIVERSITY OF SYDNEY   (Australia)

^g Four Seasons   (United States)

^h NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

ⁱ UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^j DURHAM VA MEDICAL CENTER   (United States)

^k UNIVERSITY OF ADELAIDE   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AMBIENT AIR; ARTICLE; AUSTRALIA; BLOOD OXYGEN TENSION; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DROWSINESS; DYSPNEA; EPISTAXIS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NASOGASTRIC TUBE; NOSE IRRITATION; OUTCOME ASSESSMENT; OUTPATIENT DEPARTMENT; OXYGEN THERAPY; PALLIATIVE THERAPY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; REFRACTORY DYSPNEA; UNITED KINGDOM; UNITED STATES;

EID: 77956359074     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(10)61115-4     Document Type: Article

References (38)

1. American Thoracic Society Dyspnea. Mechanisms, assessment, and management: a consensus statement Am J Respir Crit Care Med 159 1999 321 340
2. J Lynn, JM Teno, RS Phillips Perceptions by family members of the dying experience of older and seriously ill patients Ann Intern Med 126 1997 97 106
3. S Mercadante, A Casuccio, F Fulfaro The course of symptom frequency and intensity in advanced cancer patients followed at home J Pain Symptom Manage 20 2000 104 112
4. K Tanaka, T Akechi, T Okuyama, Y Nishiwaki, Y Uchitomi Prevalence and screening of dyspnea interfering with daily life activities in ambulatory patients with advanced lung cancer J Pain Symptom Manage 23 2002 484 489
5. AP Abernethy, HE Uronis, JL Wheeler, DC Currow Pharmacological management of breathlessness in advanced disease Prog Palliat Care 16 2008 15 20
6. HE Uronis, DC Currow, AP Abernethy Palliative management of refractory dyspnea in COPD Int J Chron Obstruct Pulmon Dis 1 2006 289 304
7. AP Abernethy, DC Currow, P Frith, BS Fazekas, A McHugh, C Bui Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea BMJ 327 2003 523 528
8. WJ O'Donohue, AL Plummer Magnitude of usage and cost of home oxygen therapy in the United States Chest 107 1995 301 302
9. GH Guyatt, DA McKim, P Austin Appropriateness of domiciliary oxygen delivery Chest 118 2000 1303 1308
10. JM Cranston, A Crockett, D Currow Oxygen therapy for dyspnoea in adults Cochrane Database Syst Rev 3 2008 CD004769.
11. S Booth, H Anderson, M Swannick The use of oxygen in the palliation of breathlessness. A report of the expert working group of the Scientific Committee of the Association of Palliative Medicine Respir Med 98 2004 66 77
12. JM Luce, JA Luce Perspectives on care at the close of life. Management of dyspnea in patients with far-advanced lung disease: "once I lose it, it's kind of hard to catch it..." JAMA 285 2001 1331 1337
13. AP Abernethy, DC Currow, P Frith, B Fazekas Prescribing palliative oxygen: a clinician survey of expected benefit and patterns of use Palliat Med 19 2005 168 170
14. HE Uronis, DC Currow, DC McCrory Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis Br J Cancer 98 2008 294 299
15. HE Uronis, AP Abernethy Oxygen for relief of dyspnea: what is the evidence? Curr Opin Support Palliat Care 2 2008 89 94
16. ML Nonoyama, D Brooks, GH Guyatt, RS Goldstein Effect of oxygen on health quality of life in patients with chronic obstructive pulmonary disease with transient exertional hypoxemia Am J Respir Crit Care Med 176 2007 343 349
17. IH Young, AJ Crockett, CF McDonald Adult domiciliary oxygen therapy. Position statement of the Thoracic Society of Australia and New Zealand Med J Aust 168 1998 21 25
18. RM Tierney, SM Horton, TJ Hannan, WM Tierney Relationships between symptom relief, quality of life, and satisfaction with hospice care Palliat Med 12 1998 333 344
19. MF Folstein, SE Folstein, PR McHugh "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician J Psychiatr Res 12 1975 189 198
20. RA Fisher, F Yates Statistical tables for biological, agricultural and medical research. [1974 printing] 1963 Longman London
21. G Fierro-Carrion, DA Mahler, J Ward Comparison of continuous and discrete measurements of dyspnea during exercise in patients with COPD and normal subjects Chest 125 2004 77 84
22. GR Norman, JA Sloan, KW Wyrwich Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation Med Care 41 2003 582 592
23. SR Cohen, BM Mount, E Bruera, M Provost, J Rowe, K Tong Validity of the McGill Quality of Life Questionnaire in the palliative care setting: a multi-centre Canadian study demonstrating the importance of the existential domain Palliat Med 11 1997 3 20
24. DA Mahler, CK Wells Evaluation of clinical methods for rating dypnea Chest 93 1988 580 585
25. LH Heyse-Moore On dyspnoea in advanced cancer 1993 Southampton University Southampton, UK
26. MM Oken, RH Creech, DC Tormey Toxicity and response criteria of the Eastern Cooperative Oncology Group Am J Clin Oncol 5 1982 649 655
27. RL Daut, CS Cleeland, RC Flanery Development of the Wisconsin Brief Pain Questionnaire to assess pain in cancer and other diseases Pain 17 1983 197 210
28. E Bruera, C Sweeney, J Willey A randomized controlled trial of supplemental oxygen versus air in cancer patients with dyspnea Palliat Med 17 2003 659 663
29. S Booth, MJ Kelly, NP Cox, L Adams, A Guz Does oxygen help dyspnea in patients with cancer? Am J Respir Crit Care Med 153 1996 1515 1518
30. AL Jennings, AN Davies, JP Higgins, JS Gibbs, KE Broadley A systematic review of the use of opioids in the management of dyspnoea Thorax 57 2002 939 944
31. RM Schwartzstein, K Lahive, A Pope, SE Weinberger, JW Weiss Cold facial stimulation reduces breathlessness induced in normal subjects Am Rev Respir Dis 136 1987 58 61
32. KR Burgess, WA Whitelaw Effects of nasal cold receptors on pattern of breathing J Appl Physiol 64 1988 371 376
33. Galbraith S, Perkins P, Lynch A, Booth S. Does a handheld fan improve intractable breathlessness? European Association for Palliative Care Research Forum; Trondheim, Norway; May 29-31, 2008.
34. C Bausewein, S Booth, M Gysels Non-pharmacological interventions for breathlessness in advanced stages of malignant and non-malignant diseases Cochrane Database Syst Rev 2 2008 CD005623.
35. BW Robb, ES Hungness, DD Hershko, GD Warden, RJ Kagan Home oxygen therapy: adjunct or risk factor? J Burn Care Rehabil 24 2003 403 406
36. M Gysels, IJ Higginson Access to services for patients with chronic obstructive pulmonary disease: the invisibility of breathlessness J Pain Symptom Manage 36 2008 451 460
37. HE Uronis, DC McCrory, G Samsa, DC Currow, AP Abernethy Palliative oxygen for non-hypoxaemic chronic obstructive pulmonary disease Cochrane Database Sys Rev 2 2007 CD006429.
38. DC Currow, B Fazekas, AP Abernethy Oxygen use - patients define symptomatic benefit discerningly J Pain Symptom Manage 34 2007 113 114