A functional Toll-like receptor 3 gene (TLR3) may be a risk factor for tick-borne encephalitis virus (TBEV) infection

Journal of Infectious Diseases

Volumn 203, Issue 4, 2011, Pages 523-528

  Kindberg, Elin ^a,b   Vene, Sirkka ^c   Mickiene, Aukse ^d   Lundkvist, Åke ^c   Lindquist, Lars ^e   Svensson, Lennart ^a,f  

^a LINKÖPING UNIVERSITY   (Sweden)

^b National Board of Forensic Medicine   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d KAUNAS UNIVERSITY OF MEDICINE   (Lithuania)

^e KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^f LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; TOLL LIKE RECEPTOR 3;

ARTICLE; CLINICAL ASSESSMENT; DISEASE ASSOCIATION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INNATE IMMUNITY; MAJOR CLINICAL STUDY; MENINGOENCEPHALITIS; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; TICK BORNE ENCEPHALITIS;

2',5'-OLIGOADENYLATE SYNTHETASE; DISEASE SUSCEPTIBILITY; ENCEPHALITIS VIRUSES, TICK-BORNE; ENCEPHALITIS, TICK-BORNE; HUMANS; RISK FACTORS; TOLL-LIKE RECEPTOR 3;

EID: 79751488217     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jiq082     Document Type: Article

References (33)

1. Lindenbach BP, Rice CM. Flaviviridae: The viruses their replication. In Knipe DM, Howley PM, Griffin DE et al., eds. Fields Virology, 4th ed. Vol. 1. Philadelphia, PA: Lippincott Williams & Wilkins, 2001. 1:991-1003.
2. Gritsun TS, Lashkevich VA, Gould EA. Tick-borne encephalitis. Antiviral Res 2003; 57:129-46. (Pubitemid 36254727)
3. Haglund M, Günther G. Tick-borne encephalitis - pathogenesis, clinical course long-term follow-up. Vaccine 2003; 21:S11-8.
4. Holzmann H. Diagnosis of tick-borne encephalitis. Vaccine 2003; 21:S36-40.
5. Svensson L, Kindberg E. Human genetic factors involved in viral pathogenesis. In Brasier AR, García-Sastre A, Lemon SM eds: Cellular signaling innate immune responses to RNA virus infections. Washington, DC: ASM Press, 2009; 177-93.
6. Kindberg E, Mickiene A, Ax C, et al. A deletion in the chemokine receptor 5 (CCR5) gene is associated with tickborne encephalitis. J Infect Dis 2008; 197:266-9. (Pubitemid 351263446)
7. Kumar H, Kawai T, Akira S. Toll-like receptors and innate immunity. Biochem Biophys Res Commun 2009; 388:621-5.
8. Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med 2004; 10:1366-73. (Pubitemid 40022719)
9. Daffis S, Samuel MA, Suthar MS, Gale M Jr., Diamond MS. Toll-like receptor 3 has a protective role against West Nile virus infection. J Virol 2008; 82:10349-58. (Pubitemid 352691152)
10. Hovanessian AG, Justesen J. The human 2′-5′ oligoadenylate synthetase family: Unique interferon-inducible enzymes catalyzing 2′-5′ instead of 3′-5′ phosphodiester bond formation. Biochimie 2007; 89:779-88. (Pubitemid 47001635)
11. Lim JK, Lisco A, McDermott DH, et al. Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man. PLoS Pathog 2009; 5:e1000321.
12. Mickiene A, Laiskonis A, Günther G, Vene S, Lundkvist A, Lindquist L. Tickborne encephalitis in an area of high endemicity in Lithuania: Disease severity long-term prognosis. Clin Infect Dis 2002; 35:650-8. (Pubitemid 35024723)
13. Mansfield KL, Johnson N, Phipps LP, Stephenson JR, Fooks AR, Solomon T. Tick-borne encephalitis virus - a review of an emerging zoonosis. J Gen Virol 2009; 90:1781-94.
14. Ranjith-Kumar CT, Miller W, Sun J, et al. Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity expression in cultured cells. J Biol Chem 2007; 282:17696-705. (Pubitemid 47100325)
15. Gorbea C, Makar KA, Pauschinger M, et al. A role for Toll-like receptor 3 variants in host susceptibility to enteroviral myocarditis and dilated cardiomyopathy. J Biol Chem 2010; 285:23208-23.
16. Bsibsi M, Ravid R, Gveric D, van Noort JM. Broad expression of Toll-like receptors in the human central nervous system. J Neuropathol Exp Neurol 2002; 61:1013-21. (Pubitemid 35278723)
17. Lee H, Park C, Cho IH, et al. Double-stranded RNA induces iNOS gene expression in Schwann cells, sensory neuronal death, and peripheral nerve demyelination. Glia 2007; 55:712-22. (Pubitemid 46663024)
18. Lebre MC, van der Aar AM, van Baarsen L, et al. Human keratinocytes express functional Toll-like receptor 3, 4, 5, 9. J Invest Dermatol 2007; 127:331-41. (Pubitemid 46106911)
19. Flint SJ, Enquist LW, Racaniello VR, Skalka AM. Principles of Virology. Molecular Biology, 3rd ed. Vol. 1. Washington, DC: ASM Press, 2009.
20. Liu L, Botos I, Wang Y, et al. Structural basis of Toll-like receptor 3 signaling with double-stranded RNA. Science 2008; 320:379-81. (Pubitemid 351555661)
21. Hayasaka D, Nagata N, Fujii Y, et al. Mortality following peripheral infection with tick-borne encephalitis virus results from a combination of central nervous system pathology, systemic inflammatory and stress responses. Virology 2009; 390:139-50.
22. Růzek D, Salát J, Palus M, et al. CD8+ T-cells mediate immunopathology in tick-borne encephalitis. Virology 2009; 384:1-6.
23. Le Goffic R, Balloy V, Lagranderie M, et al. Detrimental contribution of the Toll-like receptor (TLR)3 to influenza A virus-induced acute pneumonia. PLoS Pathog 2006; 2:e53.
24. Hardarson HS, Baker JS, Yang Z, et al. Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury. Am J Physiol Heart Circ Physiol 2007; 292:H251-8.
25. Negishi H, Osawa T, Ogami K, et al. A critical link between Toll-like receptor 3 type II interferon signaling pathways in antiviral innate immunity. Proc Natl Acad Sci U S A 2008; 105:20446-51.
26. Richer MJ, Lavallée DJ, Shanina I, Horwitz MS. Toll-like receptor 3 signaling on macrophages is required for survival following coxsackievirus B4 infection. PLoS One 2009; 4:e4127.
27. Zhang SY, Jouanguy E, Ugolini S, et al. TLR3 deficiency in patients with herpes simplex encephalitis. Science 2007; 317:1522-7. (Pubitemid 47417427)
28. Casrouge A, Zhang SY, Eidenschenk C, et al. Herpes simplex virus encephalitis in human UNC-93B deficiency. Science 2006; 314:308-12. (Pubitemid 44571977)
29. Ishizaki Y, Takemoto M, Kira R, et al. Association of Toll-like receptor 3 gene polymorphism with subacute sclerosing panencephalitis. J Neurovirol 2008; 14:486-91.
30. Askar E, Bregadze R, Mertens J, et al. TLR3 gene polymorphisms liver disease manifestations in chronic hepatitis C. J Med Virol 2009; 81:1204-11.
31. Hovanessian AG. Interferon-induced double-stranded RNA-activated enzymes: A specific protein kinase and 2′,5′-oligoadenylate synthetases. J Interferon Res 1991; 11:199-205. (Pubitemid 23065293)
32. Tissari J, Sirén J, Meri S, Julkunen I, Matikainen S. IFN-α enhances TLR3-mediated antiviral cytokine expression in human endothelial epithelial cells by up-regulating TLR3 expression. J Immunol 2005; 174:4289-94. (Pubitemid 40396010)
33. Robertson SJ, Mitzel DN, Taylor RT, Best SM, Bloom ME. Tick-borne flaviviruses: Dissecting host immune responses and virus countermeasures. Immunol Res 2009; 43:172-186.