Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination

Journal of Alzheimer's Disease

Volumn 22, Issue 4, 2010, Pages 1209-1221

  Milagre, Inês ^a   Nunes, Maria Joo ^a   Moutinho, Miguel ^a   Rivera, Isabel ^a   Fuso, Andrea ^b   Scarpa, Sigfrido ^b   Gama, Maria Joo ^a   Rodrigues, Elsa ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

24S hydroxycholesterol; 5' Aza 2' deoxycytidine; brain cholesterol homeostasis; CYP46A1; epigenetics; Sp transcription factors; Trichostatin A

Indexed keywords

5' AZA 2' DEOXYCYTIDINE; BISULFITE; CHOLESTEROL; CYTOCHROME P450; CYTOCHROME P46A1; DNA; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE INHIBITOR; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; PROTEIN SP3; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ARTICLE; BASAL AMYGDALA; BINDING AFFINITY; BRAIN LEVEL; CHOLESTEROL METABOLISM; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; ELECTROPHORETIC MOBILITY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE LOCUS; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 79751484908     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-100651     Document Type: Article

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