Sp proteins play a critical role in histone deacetylase inhibitor-mediated derepression of CYP46A1 gene transcription

Journal of Neurochemistry

Volumn 113, Issue 2, 2010, Pages 418-431

  Nunes, Maria João ^a   Milagre, Inês ^a   Schnekenburger, Michael ^b   Gama, Maria João ^a   Diederich, Marc ^b   Rodrigues, Elsa ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b LABORATOIRE DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE DU CANCER   (Luxembourg)

Author keywords

24(S) hydroxycholesterol; Brain cholesterol hom eostasis; CYP46A1; Epigenetics; Histone acetylation; Sp transcription factors; Trichostatin A

Indexed keywords

BUTYRIC ACID; CYTOCHROME; CYTOCHROME P450 46A1; HISTONE ACETYLTRANSFERASE PCAF; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE INHIBITOR; LUCIFERASE; PLASMID VECTOR; RNA POLYMERASE II; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; TRANSCRIPTION FACTOR SP4; TRICHOSTATIN A; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL CELL; ARTICLE; CHOLESTEROL METABOLISM; CHROMATIN IMMUNOPRECIPITATION; CHROMATIN STRUCTURE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; GENE CONSTRUCT; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; INSECT CELL; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPORTER GENE; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ANIMALS; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; DROSOPHILA MELANOGASTER; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RNA, SMALL INTERFERING; SP TRANSCRIPTION FACTORS; STATISTICS, NONPARAMETRIC; STEROID HYDROXYLASES; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION;

EID: 77949724640     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06612.x     Document Type: Article

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