Acute hyperhomocysteinaemia blunts endothelial dependent and endothelial independent vasodilatation in diabetic patients

Diabetes and Vascular Disease Research

Volumn 7, Issue 3, 2010, Pages 186-194

  Chousos, Ilias ^a   Perrea, Despoina ^a   Kyriaki, Despoina ^a   Liatis, Stavros ^a   Katsilambros, Nicholas ^a   Makrilakis, Konstantinos ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Diabetes mellitus type 2; Endothelial function; Hyperhomocysteinaemia; Iontophoresis; Laser Doppler flowmetry; Skin microcirculation

Indexed keywords

ACETYLCHOLINE; HOMOCYSTEINE; METHIONINE; NITROPRUSSIDE SODIUM;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; DIET RESTRICTION; ENDOTHELIUM; FEMALE; HUMAN; HYPERHOMOCYSTEINEMIA; LASER DOPPLER FLOWMETRY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; SKIN BLOOD FLOW; SKIN FUNCTION; VASODILATATION;

ACETYLCHOLINE; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; ENDOTHELIUM, VASCULAR; FEMALE; GREECE; HUMANS; HYPERHOMOCYSTEINEMIA; LASER-DOPPLER FLOWMETRY; MALE; METHIONINE; MICROCIRCULATION; MIDDLE AGED; NITROPRUSSIDE; SKIN; TIME FACTORS; VASODILATION; VASODILATOR AGENTS;

EID: 79551711993     PISSN: 14791641     EISSN: None     Source Type: Journal    
DOI: 10.1177/1479164110369687     Document Type: Article

References (43)

1. Ueland PM, Refsum H. (1989) Plasma homocysteine, a risk factor for vascular disease: Plasma levels in health, disease and drug therapy. J Lab Clin Med 114: 473-501. (Pubitemid 19285567)
2. Humphrey LL, Fu R., Rogers K., Freeman M., Helfand M. (2008) Homocysteine level and coronary heart disease incidence: A systematic review and meta-analysis. Mayo Clin Proc 83: 1203-12.
3. Den Heijer M., Koster T., Blom HJ, et al. (1996) Hyperhomocysteinemia as a risk factor for deep-vein thrombosis. N Engl J Med 334: 759-62. (Pubitemid 26089357)
4. Ebbing M., Bleie O., Ueland PM, et al. (2008) Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial. JAMA 300: 795-804.
5. Kannel WB, MacGee DL (1979) Diabetes and glucose tolerance as risk factors for cardiovascular disease: The Framingham study. Diabetes Care 2: 120-6. (Pubitemid 9238733)
6. UK Prospective Diabetes Study (UKPDS) Group (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352 (9131). 837-53.
7. Hoogeveen EK, Kostense PJ, Jakobs C., et al. (2000) Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes: 5-year follow-up of the Hoorn Study. Circulation 101: 1506-11. (Pubitemid 30180885)
8. Stabler SP, Estacio R., Jeffers BW, Cohen JA, Allen RH, Schrier RW (1999) Total homocysteine is associated with nephropathy in non-insulin-dependent diabetes mellitus. Metabolism 48: 1096-101. (Pubitemid 29418277)
9. Heitzer T., Schlinzig T., Krohn K., Meinertz T., Munzel T. (2001) Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104: 2673-8. (Pubitemid 33108132)
10. Austin RC, Lentz SR, Werstuck GH (2004) Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease. Cell Death Differ 11 (Suppl 1). S56 - S64. (Pubitemid 39136799)
11. Celermajer DS, Sorensen K., Ryalls M., et al. (1993) Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not their heterozygous parents. J Am Coll Cardiol 22: 854-8. (Pubitemid 23256952)
12. Tawakol A., Omland T., Gerhard M., Wu JT, Creager MA (1997) Hyperhomocyst(e)inemia is associated with impaired endothelium-dependent vasodilation in humans. Circulation 95: 1119-21. (Pubitemid 27097819)
13. Woo KS, Chook P., Lolin YI, et al. (1997) Hyperhomocyst(e) inemia is a risk factor for arterial endothelial dysfunction in humans. Circulation 96: 2542-4. (Pubitemid 27451343)
14. Bellamy MF, McDowell IFW, Ramsey MW, et al. (1998) Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults. Circulation 98: 1848-52. (Pubitemid 28509279)
15. Roman MJ, Naqvi TZ, Gardin JM, Gerhard-Herman M., Jaff M., Mohler E. (2006) Clinical application of noninvasive vascular ultrasound in cardiovascular risk stratification: a report from the American Society of Echocardiography and the Society of Vascular Medicine and Biology. J Am Soc Echocardiogr 19: 943-54. (Pubitemid 44118704)
16. Holowatz LA, Thompson-Torgerson CS, Kenney WL (2008) The human cutaneous circulation as a model of generalized microvascular function. J Appl Physiol 105: 370-2.
17. Kasha PC, Banga AK (2008) A review of patent literature for iontophoretic delivery and devices. Recent Pat Drug Deliv Formul 2: 41-50. (Pubitemid 351546433)
18. Davis KR, Pearson H., Moat S., Bonham JR, Donelly R. (2001) Acute hyperhomocysteinaemia affects pulse pressure but not microvascular vasodilator function. Br J Pharmacol 52: 327-32. (Pubitemid 33796232)
19. Abahji TN, Nill L., Ide N., Keller C., Hoffmann U., Weiss N. (2007) Acute hyperhomocysteinaemia induces microvascular and macrovascular endothelial dysfunction. Arch Med Res 38: 411-6. (Pubitemid 46528554)
20. Weiss N., Ide N., Abahji T., Nill L., Keller C., Hoffmann U. (2006) Aged garlic extract improves homocysteine-induced endothelial dysfunction in macro- and microcirculation. J Nutr 136 (Suppl 3). 750S - 754S. (Pubitemid 43363768)
21. Tousoulis D., Antoniades C., Marinou K., et al. (2008) Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin-1 levels. J Am Coll Nutr 27: 379-86.
22. Karabag T., Kaya A., Temizhan A., Koc F., Yavuz S., Cam S. (2007) The influence of homocysteine levels on endothelial function and their relation with microvascular complications in T2DM patients without macrovascular disease. Acta Diabetol 44: 69-75. (Pubitemid 46835448)
23. Newton DJ, Khan F., Belch JF (2001) Assessment of microvascular endothelial function in human skin. Clin Sci 101: 567-72. (Pubitemid 33135334)
24. Morris SJ, Shore AC, Tooke JE (1995) Responses of the skin microcirculation to acetylcholine and sodium nitroprusside in patients with NIDDM. Diabetologia 38: 1337-44.
25. Leahy MJ, de Mul FF, Nilsson GE, Maniewski R. (1997) Principles and practice of the laser-Doppler perfusion technique. Technol Health Care 7: 143-62.
26. Farkas K., Kolossvary E., Jarai Z., Nemcsik J., Farsang C. (2004) Non-invasive assessment of microvascular endothelial function by laser Doppler flowmetry in patients with essential hypertension. Atherosclerosis 173: 97-102. (Pubitemid 38224200)
27. Caballero AE, Arora S., Saouaf R., et al. (1999) Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes. Diabetes 48: 1856-62. (Pubitemid 29415208)
28. Jorneskog G., Kalani M., Kuhl J., et al. (2005) Early microvascular dysfunction in healthy normal-weight males with heredity for type 2 diabetes. Diabetes Care 28: 1495-7. (Pubitemid 40756722)
29. Friedewald WT, Levy RI, Fredickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502.
30. Cockroft D., Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16: 31-41.
31. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and b-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 28: 412-9. (Pubitemid 15018832)
32. Myer MF, Lieps D., Schatz H., Pfohl M. (2008) Impaired flow mediated vasodilatation in type 2 diabetes: Lack of relation to microvascular dysfunction. Microvasc Res 76: 61-5.
33. Hoogeveen EK, Kostense PJ, Beks PJ, et al. (1998) Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non-insulin-dependent diabetes mellitus: a population-based study. Arterioscler Thromb Vasc Biol 18: 133-8. (Pubitemid 28047610)
34. Soedamah-Muthu SS, Chaturvedi N, Teerlink T, Idzior-Walus B, Fuller JH, Stehouwer CD; Eurodiab Prospective Complications Study Group (2005) Plasma homocysteine and microvascular and macrovascular complications in type 1 diabetes: a cross-sectional nested case-control study. J Intern Med 258: 450-9. (Pubitemid 41546561)
35. Eberhardt RT, Forgione MA, Cap A., et al. (2000) Endothelial dysfunction in a murine model of mild hyperhomocyst(e) inemia. J Clin Invest 106: 483-91. (Pubitemid 30666381)
36. Cai H., Harrison DG (2000) Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87: 840-4.
37. Di Carli MF, Janisse J., Grunberger G., Ager J. (2003) Role of chronic hyperglycemia in the pathogenesis of coronary microvascular dysfunction in diabetes. J Am Coll Cardiol 41: 1387-93. (Pubitemid 36439001)
38. Adams MR, Robinson J., McCredie R., et al. (1998) Smooth muscle dysfunction occurs independently of impaired endothelium-dependent dilation in adults at risk of atherosclerosis. J Am Coll Cardiol 32: 123-7. (Pubitemid 28351052)
39. Bucala R., Tracey KJ, Cerami A. (1991) Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest 87: 432-8.
40. Elias AN, Eng S. (2005) Homocysteine concentrations in patients with diabetes mellitus - relationship to microvascular and macrovascular disease. Diabetes Obes Metab 7: 117-21. (Pubitemid 40352726)
41. Diakoumopoulou E., Tentolouris N., Kirlaki E., et al. (2005) Plasma homocysteine levels in patients with type 2 diabetes in a Mediterranean population: Relation with nutritional and other factors. Nutr Metab Cardiovasc Dis 15: 109-17. (Pubitemid 40712475)
42. Emoto M., Kanda H., Shoji T., et al. (2001) Impact of insulin resistance and nephropathy on homocysteine in type 2 diabetes. Diabetes Care 24: 533-8. (Pubitemid 32198426)
43. Bulow J., Astrup A., Christensen NJ, Kastrup J. (1987) Blood flow in skin, subcutaneous adipose tissue and skeletal muscle in the forearm of normal man during an oral glucose load. Acta Physiol Scand 130: 657-61. (Pubitemid 17148402)