Using HSV-TK/GCV suicide gene therapy to inhibit lens epithelial cell proliferation for treatment of posterior capsular opacification

Molecular Vision

Volumn 17, Issue , 2011, Pages 291-299

  Jiang, Yong Xiang ^a   Lu, Yi ^a   Liu, Tian Jing ^b   Yang, Jin ^a   Chen, Yan ^a   Fang, Yan Wen ^a  

^a FUDAN UNIVERSITY   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; GANCICLOVIR; LENTIVIRUS VECTOR; PHOSPHOGLYCERATE KINASE; THYMIDINE KINASE;

APOPTOSIS; ARTICLE; CAPSULE OPACIFICATION; CATARACT EXTRACTION; CELL DEATH; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG TARGETING; GENE ACTIVATION; GENE CONSTRUCT; GENE EXPRESSION SYSTEM; GENE SEQUENCE; GENE SWITCHING; GENETIC TRANSDUCTION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; LENS EPITHELIUM; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROMOTER REGION; SUICIDE GENE THERAPY; VIRAL GENE DELIVERY SYSTEM;

ANTIVIRAL AGENTS; APOPTOSIS; CATARACT; CATARACT EXTRACTION; CELL LINE; CELL PROLIFERATION; FLOW CYTOMETRY; GANCICLOVIR; GENE THERAPY; HUMANS; INTEGRASES; LENTIVIRUS; MODELS, GENETIC; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; SIMPLEXVIRUS; THYMIDINE KINASE;

EID: 79551705822     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Nishi O. Posterior capsule opacification. Part 1: Experimental investigations. J Cataract Refract Surg 1999; 25:106-17. [PMID: 9888086]
2. Ashwin PT, Shah S, Wolffsohn JS. Advances in cataract surgery. Clin Exp Optom 2009; 92:333-42. [PMID: 19570151]
3. Ozkurt YB, Sengor T, Evciman T, Haboglu M. Refraction, intraocular pressure and anterior chamber depth changes after Nd:YAG laser treatment for posterior capsular opacification in pseudophakic eyes. Clin Exp Optom 2009; 92:412-5. [PMID: 19549226]
4. Roh JH, Sohn HJ, Lee DY, Shyn KH, Nam DH. Comparison of posterior capsular opacification between a combined procedure and a sequential procedure of pars plana vitrectomy and cataract surgery. Ophthalmologica 2010; 224:42-6. [PMID: 19684427]
5. Awasthi N, Guo S, Wagner BJ. Posterior capsular opacification: a problem reduced but not yet eradicated. Arch Ophthalmol 2009; 127:555-62. [PMID: 19365040]
6. Yadav UC, Ighani-Hosseinabad F, van Kuijk FJ, Srivastava SK, Ramana KV. Prevention of posterior capsular opacification through aldose reductase inhibition. Invest Ophthalmol Vis Sci 2009; 50:752-9. [PMID: 19011011]
7. Gu F, Zhai H, Li D, Zhao L, Li C, Huang S, Ma X. A novel mutation in major intrinsic protein of the lens gene (MIP) underlies autosomal dominant cataract in a Chinese family. Mol Vis 2007; 13:1651-6. [PMID: 17893667]
8. Rönbeck M, Zetterstrom C, Wejde G, Kugelberg M. Comparison of posterior capsule opacification development with 3 intraocular lens types: five-year prospective study. J Cataract Refract Surg 2009; 35:1935-40. [PMID: 19878826]
9. Vasavada AR, Dholakia SA, Raj SM, Singh R. Effect of cortical cleaving hydrodissection on posterior capsule opacification in age-related nuclear cataract. J Cataract Refract Surg 2006; 32:1196-200. [PMID: 16857509]
10. Vasavada AR, Nihalani BR. Pediatric cataract surgery. Curr Opin Ophthalmol 2006; 17:54-61. [PMID: 16436925]
11. Couderc BC, de Neuville S, Douin-Echinard V, Serres B, Manenti S, Darbon JM, Malecaze F. Retrovirus-mediated transfer of a suicide gene into lens epithelial cells in vitro and in an experimental model of posterior capsule opacification. Curr Eye Res 1999; 19:472-82. [PMID: 10550788]
12. Malecaze F, Couderc B, de Neuville S, Serres B, Mallet J, Douin-Echinard V, Manenti S, Revah F, Darbon JM. Adenovirus-mediated suicide gene transduction: feasibility in lens epithelium and in prevention of posterior capsule opacification in rabbits. Hum Gene Ther 1999; 10:2365-72. [PMID: 10515456]
13. Wang B, Weng J. Effects of adenovirus-mediated HSV-tk/GCV system on lens epithelium. Zhonghua Yan Ke Za Zhi 2002; 38:618-22. [PMID: 12487913]
14. Denny WA. Prodrugs for Gene-Directed Enzyme-Prodrug Therapy (Suicide Gene Therapy). J Biomed Biotechnol 2003; 2003:48-70. [PMID: 12686722]
15. Maeda M, Namikawa K, Kobayashi I, Ohba N, Takahara Y, Kadono C, Tanaka A, Kiyama H. Targeted gene therapy toward astrocytoma using a Cre/loxP-based adenovirus system. Brain Res 2006; 1081:34-43. [PMID: 16529724]
16. Nicholas TW, Read SB, Burrows FJ, Kruse CA. Suicide gene therapy with Herpes simplex virus thymidine kinase and ganciclovir is enhanced with connexins to improve gap junctions and bystander effects. Histol Histopathol 2003; 18:495-507. [PMID: 12647801]
17. Wen Y, Sachs G, Athmann C. A novel lens epithelium gene, LEP503, is highly conserved in different vertebrate species and is developmentally regulated in postnatal rat lens. Exp Eye Res 2000; 70:159-68. [PMID: 10655141]
18. Wen Y, Ibaraki N, Reddy VN, Sachs G. Functional analysis of the promoter and chromosomal localization for human LEP503, a novel lens epithelium gene. Gene 2001; 269:61-71. [PMID: 11376938]
19. Malecaze F, Lubsen NH, Serre B, Decha A, Duboue M, Penary M, Berg D, Arnaud JD, Titeux M, Kremer EJ, Couderc B. Lens cell targeting for gene therapy of prevention of posterior capsule opacification. Gene Ther 2006; 13:1422-9. [PMID: 16724094]
20. Yang J, Liu TJ, Lu Y. Effects of bicistronic lentiviral vectormediatedherpes simplex virus thymidine kinase/ganciclovir system on human lens epithelial cells. Curr Eye Res 2007; 32:33-42. [PMID: 17364733]
21. Yang J, Lu Y, Guo LH, Liu TJ, Mo XF. The effect of lentivirusmediated suicide gene therapy on lens epithelial cells. Zhonghua Yan Ke Za Zhi 2007; 43:810-6. [PMID: 18070527]
22. Goto H, Osaki T, Kijima T, Nishino K, Kumagai T, Funakoshi T, Kimura H, Takeda Y, Yoneda T, Tachibana I, Hayashi S. Gene therapy utilizing the Cre/loxP system selectively suppresses tumor growth of disseminated carcinoembryonic antigen-producing cancer cells. Int J Cancer 2001; 94:414-9. [PMID: 11745423]
23. Greco O, Joiner MC, Doleh A, Powell AD, Hillman GG, Scott SD. Hypoxia- and radiation-activated Cre/loxP 'molecular switch' vectors for gene therapy of cancer. Gene Ther 2006; 13:206-15. [PMID: 16307003]
24. Kijima T, Osaki T, Nishino K, Kumagai T, Funakoshi T, Goto H, Tachibana I, Tanio Y, Kishimoto T. Application of the Cre recombinase/loxP system further enhances antitumor effects in cell type-specific gene therapy against carcinoembryonic antigen-producing cancer. Cancer Res 1999; 59:4906-11. [PMID: 10519403]
25. Nagayama Y, Nishihara E, Iitaka M, Namba H, Yamashita S, Niwa M. Enhanced efficacy of transcriptionally targeted suicide gene/prodrug therapy for thyroid carcinoma with the Cre-loxP system. Cancer Res 1999; 59:3049-52. [PMID: 10397242]
26. Kanegae Y, Lee G, Sato Y, Tanaka M, Nakai M, Sakaki T, Sugano S, Saito I. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing sitespecific Cre recombinase. Nucleic Acids Res 1995; 23:3816-21. [PMID: 7479022]
27. Ueda K, Iwahashi M, Nakamori M, Nakamura M, Yamaue H, Tanimura H. Enhanced selective gene expression by adenovirus vector using Cre/loxP regulation system for human carcinoembryonic antigen-producing carcinoma. Oncology 2000; 59:255-65. [PMID: 11053994]
28. Krag S, Andreassen TT. Mechanical properties of the human posterior lens capsule. Invest Ophthalmol Vis Sci 2003; 44:691-6. [PMID: 12556400]
29. Morgenbesser SD, Williams BO, Jacks T, DePinho RA. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 1994; 371:72-4. [PMID: 8072529]