Orf virus ORFV121 encodes a novel inhibitor of NF-κB that contributes to virus virulence

Journal of Virology

Volumn 85, Issue 5, 2011, Pages 2037-2049

  Diel, D G ^a,b   Luo, S ^a   Delhon, G ^c   Peng, Y ^a,d   Flores, E F ^b   Rock, D L ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^c UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^d SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B; ORFV121 PROTEIN; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOPLASM; GENE DELETION; GENE EXPRESSION; HOST CELL; NONHUMAN; POXVIRUS; POXVIRUS INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; VIRAL GENETICS; VIRUS VIRULENCE;

ANIMALS; CELL LINE; CELL NUCLEUS; ECTHYMA, CONTAGIOUS; GENE EXPRESSION REGULATION, VIRAL; HELA CELLS; HUMANS; ORF VIRUS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TRANSPORT; SHEEP; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; VIRAL PROTEINS; VIRULENCE;

ORF VIRUS; OVIS ARIES; PARAPOXVIRUS; POXVIRIDAE;

EID: 79551701136     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02236-10     Document Type: Article

References (52)

1. Bartlett, N., J. A. Symons, D. C. Tscharke, and G. L. Smith. 2002. The vaccinia virus N1L protein is an intracellular homodimer that promotes virulence. J. Gen. Virol. 83:1965-1976.
2. Bohuslav, J., L. F. Chen, H. Kwon, Y. Mu, and W. C. Greene. 2004. p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1. J. Biol. Chem. 279:26115-26125.
3. Bowie, A., et al. 2000. A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. Proc. Natl. Acad. Sci. U. S. A. 97:10162-10167.
4. Camus-Bouclainville, C., et al. 2004. A virulence factor of myxoma virus colocalizes with NF-kappaB in the nucleus and interferes with inflammation. J. Virol. 78:2510-2516. (Pubitemid 38228945)
5. Chang, S. J., et al. 2009. Poxvirus host range protein CP77 contains an F-box-like domain that is necessary to suppress NF-kappaB activation by tumor necrosis factor alpha but is independent of its host range function. J. Virol. 83:4140-4152.
6. Chen, L. F., and W. C. Greene. 2004. Shaping the nuclear action of NF-kappaB. Nat. Rev. Mol. Cell Biol. 5:392-401.
7. Chen, L. F., et al. 2005. NF-kappaB RelA phosphorylation regulates RelA acetylation. Mol. Cell Biol. 25:7966-7975.
8. Chen, R. A., G. Ryzhakov, S. Cooray, F. Randow, and G. L. Smith. 2008. Inhibition of IkappaB kinase by vaccinia virus virulence factor B14. PLoS Pathog. 4:e22.
9. de la Concha-Bermejillo, A., J. Guo, Z. Zhang, and D. Waldron. 2003. Severe persistent orf in young goats. J. Vet. Diagn. Investig. 15:423-431.
10. Delhon, G., et al. 2004. Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus. J. Virol. 78:168-177. (Pubitemid 37549729)
11. Diel, D. G., G. Delhon, S. Luo, E. F. Flores, and D. L. Rock. 2010. A novel inhibitor of the NF-kappaB signaling pathway encoded by the parapoxvirus orf virus. J. Virol. 84:3962-3973.
12. Diel, D. G., et al. 2011. A nuclear inhibitor of NF-κB encoded by a poxvirus. J. Virol. 85:264-275.
13. DiPerna, G., et al. 2004. Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by tolllike receptors. J. Biol. Chem. 279:36570-36578.
14. Dvoracek, B., and T. Shors. 2003. Construction of a novel set of transfer vectors to study vaccinia virus replication and foreign gene expression. Plasmid 49:9-17. (Pubitemid 36269165)
15. Erickson, G. A., E. A. Carbrey, and G. A. Gustafson. 1975. Generalized contagious ecthyma in a sheep rancher: diagnostic considerations. J. Am. Vet. Med. Assoc. 166:262-263.
16. Fleming, S. B., and A. A. Mercer. 2007. Genus Parapoxvirus, p. 127-165. In A. A. Mercer, A. Schmidt, and O. Weber (ed.), Poxviruses. Birkhäuser, Basel, Switzerland.
17. Gedey, R., X. L. Jin, O. Hinthong, and J. L. Shisler. 2006. Poxviral regulation of the host NF-kappaB response: the vaccinia virus M2L protein inhibits induction of NF-kappaB activation via an ERK2 pathway in virus-infected human embryonic kidney cells. J. Virol. 80:8676-8685.
18. Guo, J., et al. 2003. Characterization of a North American orf virus isolated from a goat with persistent, proliferative dermatitis. Virus Res. 93:169-179. (Pubitemid 36628004)
19. Haig, D. M., and C. J. McInnes. 2002. Immunity and counter-immunity during infection with the parapoxvirus orf virus. Virus Res. 88:3-16.
20. Haig, D. M., and A. A. Mercer. 1998. Ovine diseases. Orf. Vet. Res. 29:311-326.
21. Harte, M. T., et al. 2003. The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense. J. Exp. Med. 197:343-351.
22. Hautaniemi, M., et al. 2010. The genome of pseudocowpoxvirus: comparison of a reindeer isolate and a reference strain. J. Gen. Virol. 91:1560-1576.
23. Jenkinson, D. M., P. E. McEwan, V. A. Moss, H. Y. Elder, and H. W. Reid. 1990. Location and spread of orf virus antigen in infected ovine skin. Vet. Dermatol. 1:189-195.
24. Johnston, J. B., et al. 2005. A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection. Immunity 23:587-598. (Pubitemid 41779481)
25. Karin, M., and Y. Ben-Neriah. 2000. Phosphorylation meets ubiquitination: the control of NF-kappaB activity. Annu. Rev. Immunol. 18:621-663.
26. Liu, B., et al. 2008. IKKalpha is required to maintain skin homeostasis and prevent skin cancer. Cancer Cell 14:212-225.
27. McKeever, D. J., D. M. Jenkinson, G. Hutchison, and H. W. Reid. 1988. Studies of the pathogenesis of orf virus infection in sheep. J. Comp. Pathol. 99:317-328.
28. Mohamed, M. R., and G. McFadden. 2009. NFkappaB inhibitors: strategies from poxviruses. Cell Cycle 8:3125-3132.
29. Mohamed, M. R., et al. 2009. Proteomic screening of variola virus reveals a unique NF-kappaB inhibitor that is highly conserved among pathogenic orthopoxviruses. Proc. Natl. Acad. Sci. U. S. A. 106:9045-9050.
30. Mohamed, M. R., et al. 2009. Cowpox virus expresses a novel ankyrin repeat NF-kappaB inhibitor that controls inflammatory cell influx into virus-infected tissues and is critical for virus pathogenesis. J. Virol. 83:9223-9236.
31. Moss, B. 2007. Poxviruses: the viruses and their replication, p. 2905-2946. In D. M. Knipe and P. M. Howley (ed.), Fields virology, 5th ed., vol. 2. Wolters Kluwer Health/Lippincott Williams & Wilkins, Philadelphia, PA.
32. Mourtada, I., M. Le Tourneur, J. Chevrant-Breton, and F. Le Gall. 2000. Human orf and erythema multiforme. Ann. Dermatol. Venereol. 127:397-399.
33. Murao, L. E., and J. L. Shisler. 2005. The MCV MC159 protein inhibits late, but not early, events of TNF-alpha-induced NF-kappaB activation. Virology 340:255-264.
34. Myskiw, C., J. Arsenio, R. van Bruggen, Y. Deschambault, and J. Cao. 2009. Vaccinia virus E3 suppresses expression of diverse cytokines through inhibition of the PKR, NF-kappaB, and IRF3 pathways. J. Virol. 83:6757-6768.
35. Ndikuwera, J., et al. 1992. Chronic contagious ecthyma and caseous lymphadenitis in two Boer goats. Vet. Rec. 131:584-585.
36. Nestle, F. O., P. Di Meglio, J. Z. Qin, and B. J. Nickoloff. 2009. Skin immune sentinels in health and disease. Nat. Rev. Immunol. 9:679-691.
37. Nettleton, P. F., J. A. Gilray, D. L. Yirrell, G. R. Scott, and H. W. Reid. 1996. Natural transmission of orf virus from clinically normal ewes to orf-naive sheep. Vet. Rec. 139:364-366.
38. Nichols, D. B., and J. L. Shisler. 2009. Poxvirus MC160 protein utilizes multiple mechanisms to inhibit NF-kappaB activation mediated via components of the tumor necrosis factor receptor 1 signal transduction pathway. J. Virol. 83:3162-3174.
39. Pasparakis, M. 2009. Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases. Nat. Rev. Immunol. 9:778-788.
40. Perkins, N. D. 2006. Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway. Oncogene 25:6717-6730. (Pubitemid 44657848)
41. Perkins, N. D. 2007. Integrating cell-signalling pathways with NF-kappaB and IKK function. Nat. Rev. Mol. Cell Biol. 8:49-62.
42. Rahman, M. M., M. R. Mohamed, M. Kim, S. Smallwood, and G. McFadden. 2009. Co-regulation of NF-kappaB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein M013. PLoS Pathog. 5:e1000635.
43. Sanchez, R. L., A. Hebert, H. Lucia, and J. Swedo. 1985. Orf. A case report with histologic, electron microscopic, and immunoperoxidase studies. Arch. Pathol. Lab. Med. 109:166-170.
44. Scheidereit, C. 2006. IkappaB kinase complexes: gateways to NF-kappaB activation and transcription. Oncogene 25:6685-6705. (Pubitemid 44657846)
45. Seitz, C. S., Q. Lin, H. Deng, and P. A. Khavari. 1998. Alterations in NF-kappaB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kappaB. Proc. Natl. Acad. Sci. U. S. A. 95:2307-2312.
46. Shisler, J. L., and X. L. Jin. 2004. The vaccinia virus K1L gene product inhibits host NF-kappaB activation by preventing IkappaBalpha degradation. J. Virol. 78:3553-3560.
47. Sonnberg, S., S. B. Fleming, and A. A. Mercer. 2009. A truncated two-alphahelix F-box present in poxvirus ankyrin-repeat proteins is sufficient for binding the SCF1 ubiquitin ligase complex. J. Gen. Virol. 90:1224-1228.
48. Stack, J., et al. 2005. Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence. J. Exp. Med. 201:1007-1018.
49. Vallabhapurapu, S., and M. Karin. 2009. Regulation and function of NF-kappaB transcription factors in the immune system. Annu. Rev. Immunol. 27:693-733.
50. Wan, F., and M. J. Lenardo. 2010. The nuclear signaling of NF-kappaB: current knowledge, new insights, and future perspectives. Cell Res. 20:24-33.
51. Weisfelner, M. E., and A. B. Gottlieb. 2003. The role of apoptosis in human epidermal keratinocytes. J. Drugs Dermatol. 2:385-391.
52. Yirrell, D. L., H. W. Reid, M. Norval, G. Entrican, and H. R. Miller. 1991. Response of efferent lymph and popliteal lymph node to epidermal infection of sheep with orf virus. Vet. Immunol. Immunopathol. 28:219-235.