Homocysteine and P wave dispersion in patients with heart transplantation

Clinical Transplantation

Volumn 25, Issue 1, 2011, Pages 119-125

  Acampa, Maurizio ^a   Lazzerini, Pietro Enea ^a   Guideri, Francesca ^a   Rechichi, Serena ^a   Capecchi, Pier Leopoldo ^a   Maccherini, Massimo ^b   Laghi Pasini, Franco ^a  

^a Department of Clinical Medicine and Immunological Sciences ^*  (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

Cardiac arrhythmias; Homocysteine; Orthotopic heart transplantation; P wave dispersion; QT interval

Indexed keywords

HOMOCYSTEINE;

ADULT; ARRHYTHMOGENESIS; ARTICLE; BLOOD LEVEL; CARDIOMYOPATHY; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRIC CONDUCTIVITY; FEMALE; HEART ATRIUM CONDUCTION; HEART DENERVATION; HEART MUSCLE; HEART TRANSPLANTATION; HUMAN; ISCHEMIC CARDIOMYOPATHY; MALE; NON ISCHEMIC CARDIOMYOPATHY; ORTHOTOPIC HEART TRANSPLANTATION; P WAVE; P WAVE DISPERSION; PRIORITY JOURNAL; PROSPECTIVE STUDY; QT DISPERSION; QT INTERVAL;

ARRHYTHMIAS, CARDIAC; CASE-CONTROL STUDIES; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HEART; HEART TRANSPLANTATION; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 79551691878     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2009.01126.x     Document Type: Article

References (35)

1. Malinow MR. Homocysteine and arterial occlusives diseases. J Int Med 1994: 236: 603.
2. Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. J Am Med Assoc 2002: 288: 2015.
3. Bostom AG, Selhub J. Homocysteine and arteriosclerosis: subclinical and clinical disease associations. Circulation 1999: 99: 2361.
4. Wierzbicki AS. Homocysteine and cardiovascular disease: a review of the evidence. Diabetes Vasc Dis Res 2007: 4: 143.
5. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Eng J Med 1998: 338: 1042.
6. Thambyrajah J, Townend JN. Homocysteine and atherothrombosis - mechanisms for injury. Eur Heart J 2000: 21: 967.
7. Perla-Kajan J, Twardowski T, Jakubowski H. Mechanisms of homocysteine toxicity in humans. Amino Acids 2007: 32: 561.
8. Jakubowski H. Molecular basis of homocysteine toxicity in humans. Cell Mol Life Sci 2004: 61: 470.
9. Ambrosi P, Barlatier A, Habib G et al. Hyperhomocysteinaemia in heart transplant recipients. Eur Heart J 1994: 15: 1191.
10. Lazzerini PE, Capecchi PL, Maccherini M et al. Early and delayed increase in plasma homocysteine levels in heart transplanted patients. Transplant Proc 2002: 34: 1275.
11. Kutschka I, Pethig K, Harringer W, Haverich A, Strüber M. Hannover Thoracic Transplant Program. Increased plasma homocysteine concentrations accelerate cardiac allograft vasculopathy. J Heart Lung Transplant 2004: 23: 1260.
12. Potena L, Grigioni F, Magnani G et al. Homocysteine-lowering therapy and early progression of transplant vasculopathy: a prospective, randomized, IVUS-based study. Am J Transplant 2005: 5: 2258.
13. Ahmari SA, Bunch TJ, Chandra A et al. Prevalence, pathophysiology, and clinical significance of post-heart transplant atrial fibrillation and atrial flutter. J Heart Lung Transplant 2006: 25: 53.
14. Vaseghi M, Boyle NG, Kedia R et al. Supraventricular tachycardia after orthotopic cardiac transplantation. J Am Coll Cardiol 2008: 51: 2241.
15. Ali A, Mehra MR, Malik FS, Uber PA, Ventura HO. Insights into ventricular repolarization abnormalities in cardiac allograft vasculopathy. Am J Cardiol 2001: 87: 367.
16. Vrtovec B, Radovancevic R, Thomas CD, Yazdabakhsh AP, Smart FW, Radovancevic B. Prognostic value of the QTc interval after cardiac transplantation. J Heart Lung Transplant 2006: 25: 29.
17. Carroll JF, Tyagi SC. Extracellular matrix remodeling in the heart of the homocysteinemic obese rabbit. Am J Hypertens 2005: 18: 692.
18. Shimano M, Inden Y, Tsuji Y et al. Circulating homocysteine levels in patients with radiofrequency catheter ablation for atrial fibrillation. Europace 2008: 10: 961.
19. Pacher P, Ungvari Z, Kecskemeti V. Electrophysiological effects of homocysteine in isolated rat right ventricular papillary muscles and left atria. Gen Pharmacol 1999: 32: 439.
20. Shontz RD, Xu Z, Patel KP, Rozanski GJ. Inhibition of K+ currents by homocysteine in rat ventricular myocytes. J Cardiovasc Electrophysiol 2001: 12: 175.
21. Cai BZ, Gong DM, Liu Y et al. Homocysteine inhibits potassium channels in human atrial myocytes. Clin Exp Pharmacol Physiol 2007: 34: 851.
22. Cai B, Pan Z, Gong D et al. Homocysteine modulates sodium channel currents in human atrial myocytes. Toxicology 2009, doi:.
23. Michelucci A, Bagliani G, Colella A et al. P wave assessment: state of the art update. Card Electrophysiol Rev 2002: 6: 215.
24. Can I, Aytemir K, Köse S, Oto A. Physiological mechanisms influencing cardiac repolarization and QT interval. Card Electrophysiol Rev 2002: 6: 278.
25. Magnano AR, Holleran S, Ramakrishnan R, Reiffel JA, Bloomfield DM. Autonomic nervous system influences on QT interval in normal subjects. J Am Coll Cardiol 2002: 39: 1820.
26. Cheema AN, Ahmed MW, Kadish AH, Goldberger JJ. Effects of autonomic stimulation and blockade on signal averaged P wave duration. J Am Coll Cardiol 1995: 26: 497.
27. Dilaveris P, Batchvarov V, Gialafos J, Malik M. Comparison of different methods for manual P wave duration measurement in 12-lead electrocardiograms. PACE 1999: 22: 1532.
28. Garson A. How to measure the QT interval-What is normal? Am J Cardiol 1993: 72: 14B.
29. Funck Brentano C, Jailon P. Rate corrected QT interval. Techniques and limitations. Am J Cardiol 1993: 72: 17B.
30. Malik M, Batchvarov N. Measurement, interpretation and clinical potential of QT dispersion. J Am Coll Cardiol 2000: 36: 1749.
31. Marcucci R, Betti I, Cecchi E et al. Hyperhomocysteinemia and vitamin B6 deficiency: new risk markers for nonvalvular atrial fibrillation? Am Heart J 2004: 148: 456.
32. Miller A, Mujumdar V, Palmer L, Bower JD, Tyagi SC. Reversal of endocardial endothelial dysfunction by folic acid in homocysteinemic hypertensive rats. Am J Hypertens 2002: 15: 157.
33. Tyagi N, Moshal KS, Lominadze D, Ovechkin AV, Tyagi SC. Homocysteine-dependent cardiac remodeling and endothelial-myocyte coupling in a 2 kidney, 1 clip Goldblatt hypertension mouse model. Can J Physiol Pharmacol 2005: 83: 583.
34. Van Wagoner DR. Electrophysiological remodelling in human atrial fibrillation. Pacing Clin Electrophysiol 2003: 26: 1572.
35. K1 in action potential shortening associated with atrial fibrillation in humans. Cardiovasc Res 2005: 6: 493.