Physiological mechanisms influencing cardiac repolarization and QT interval

Cardiac Electrophysiology Review

Volumn 6, Issue 3, 2002, Pages 278-281

  Can, Ilknur ^a   Aytemir, Kudret ^a   Köse, Sedat ^a   Oto, Ali ^a  

^a NONE   (Turkey)

Author keywords

QT interval; Repolarization; T wave alternans

Indexed keywords

POTASSIUM ION;

ARTICLE; AUTONOMIC NERVOUS SYSTEM; CONTROLLED STUDY; GENDER; HEART CYCLE; HEART RATE; HEART REPOLARIZATION; HEART VENTRICLE ARRHYTHMIA; HUMAN; NONHUMAN; POTASSIUM CURRENT; PREDICTION; QT INTERVAL; REGULATORY MECHANISM; T WAVE;

ARRHYTHMIA; AUTONOMIC NERVOUS SYSTEM; ELECTROCARDIOGRAPHY; HEART; HUMANS; ION CHANNELS; MEMBRANE POTENTIALS; VENTRICULAR FUNCTION;

EID: 0036754850     PISSN: 13852264     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016341311646     Document Type: Article

References (32)

1. Snyders DJ. Structure and function of cardiac potassium channels. Cardiovasc Res 1999;42:377-390.
2. Litovski SH, Antzelevitch C. Rate dependency of action potential duration and refractoriness in canine ventricular endocardium differs from that of epicardium: Role of transient outward current. J Am Coll Cardiol 1989;14:1053-1066.
3. Näbauer M, Bueckelmann DJ, Überfuhr P, Steinbeck G. Regional differences in current density and rate-dependent properties of the transient outward current in the subepicardial and subendocardial myocytes of human left ventricle. Circulation 1996;93:168-177.
4. Solberg LE, Singer DH, Ten Eick RE, Duffin EG. Glass microelectrode studies on intramural papillary cells. Description of preparation and studies on normal dog papillary muscle. Circ Res 1974;34: 783-797.
5. Antzelevitch C, Sicouri S, Lukas A, et al. Regional differences in the electrophysiology of ventricular cells: Physiological and clinical implications. In: Zipes D, Jalife J (eds). Cardiac Electrophysiology: From Cell to Bedside. Philadelphia: W.B. Saunders Co.: 1995;228-245.
6. Antzelevitch C, Shimizu W, Yan GX, Sicouri S, Weissenburger J, Nesterenko VV, Burashnikov A, Di Diego J, Saffitz J, Thomas GP. The M cell: Its contribution to the ECG and to normal and abnormal electrical function of the heart. J Cardiovasc Electrophysiol 1999;10:1124-1152.
7. Anyukhovsky EP, Sosunov EA, Gainullin RZ, Rosen MR. The contoversial M cell. J Cardiovasc Electrophysiol 1999;10:244-260.
8. Kääb S, Näbauer M. Diversity of ionic channel expression in health and disease. Myocardial repolarisation from gene to bedside 2001;33-56.
9. Shimizu W, Antzelevitch C. Cellular basis for the ECG features of the LQT1 form of the long-QT syndrome. Effects of beta-adrenergic agonists and sodium channel blockers on transmural dispersion of repolarisation and torsade de pointes. Circulation 1998;98:2314-2322.
10. Antzelevitch C, Sicouri S, Litovsky SH, Lukas A, Krishnan SC, Di Diego JM, Gintant GA, Liu DW. Heterogeneity within the ventricular wall-electrophysiology and pharmacology of epicardial, endocardial, and M-cells. Circ Res 1991;69:1427-1449.
11. Anyukhovsky EP, Sosunov EA, Rosen MR. Regional differences in electrophysiological properties of epicardium, midmyocardium, and endocardium. In vitro and in vivo correlations. Circulation 1996;94: 1981-1988.
12. Sosunov EA, Anyukhovsky EP, Rosen MR. Effects of quinidine on repolarisation in canine epicardium, midmyocardium, and endocardium: 1. In vitro study. Circulation 1997;96:4011-4018.
13. Anyukhovsky EP, Sosunov EA, Feinmark SJ, Rosen MR. Effects of quinidine on repolarisation on repolarisation in canine epicardium, midmyocardium, and endocardium: 2. In vivo study. Circulation 1997;96:4019-4026.
14. Lepeschkin E, Surawicz B. The measurement of the duration of the QRS interval. Am Heart J 1953;44:80.
15. Mines GR. On dynamic equilibrium in the heart. J Physiol (Lond) 1913;46:349-383.
16. Lepeschkin E, Modern Electrocardiography, Vol 1. Baltimore: Williams & Wilkins, 1951.
17. Shipler RR, Hallaran WR. The four lead electrocardiogram in two hundred normal men and women. Am Heart J 1936;11:325.
18. Moss AJ. Measurement of the QT interval and the risk associated with QTc interval prolongation: A review. Am J Cardiol 1993;72:23B-25B.
19. Browne KF, Zipes DP, Heger JJ, Pyrstowsky K. Influence of the autonomic nervous system on the QT interval in man. Am J Cardiol 1982;50:1099.
20. Puddu PE, Jouve R, Mariotti S, Giampaoli S, Lanti M, Reale A, Menotti A. Evaluation of 10 QT prediction formulas in 881 middle-aged men from the seven countries study: Emphasis on the cubic root Fridericia's equation. J Electrocardiol 1988;21:219.
21. Sagie A, Larson MG, Goldberg RJ, Bengtson JR, Levy D. An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study). Am J Cardiol 1992;70:797.
22. Rasmussen V, Jensen G, Hansen JF. QT interval in 24-hour ambulatory ECG recordings from 60 healthy adult subjects. J Electrocardiol 1991;24:91.
23. Morganroth J, Brozovich FV, McDonald JT, Jacobs RA. Variability of the QT measurement in healthy men, with implications for selection of an abnormal QT value to predict drug toxicity and proarrhythmia. Am J Cardiol 1991;67:774.
24. Ahnve S. Errors in the visual determination of corrected QT (QTc) interval during acute myocardial infarction. J Am Coll Cardiol 1985;5:699.
25. Boudoulas H, Sohn YH, O'Neill W, Brown R, Weissler AM. The QT > QS2 syndrome: A new mortality risk indicator in coronary artery disease. Am J Cardiol 1982;50:1229.
26. Abilskov JA. The prolonged QT interval. Annu Rev Med 1979;30:171.
27. Murakawa Y, Yamashita T, Ajiki K, Suzuki J, Fukui E, Kasaoka Y, Omata M, Nagai R. Is the QT interval an indicator of autonomic state? Jpn Heart J 2000;41:713-721.
28. Whitsel EA, Boyko EJ, Siscovick DS. Reassesing the role of QTc in the diagnosis of autonomic failure among patients with diabetes: A metanalysis. Diabetes Care 2000;23:241-247.
29. Davey P. QT interval lengthin cardiac disease relates more to left ventricular systolic dysfunction than to autonomic function. Eur J Heart Fail 2000;2:265-271.
30. Adam DR, Smith JM, Akselrod S, Nyberg S, Powell AO, Cohen RJ. Fluctuations in T-wave morphology and susceptibility to ventricular fibrillation. J Electrocardiol 1984;17:209-218.
31. Adam D, Akselrod S, Cohen R. Estimation of ventricular vulnerability to fibrillation through T-wave time series analysis. Comput Cardiol 1981;307-310.
32. Pastore JM, Girouard SD, Laurita KR, Akar FG, Rosenbaum DS. Mechanism linking T wave alternans to the genesis of cardiac fibrillation. Circulation 1999;99:1385-1394.