Homocysteine inhibits potassium channels in human atrial myocytes

Clinical and Experimental Pharmacology and Physiology

Volumn 34, Issue 9, 2007, Pages 851-855

  Cai, Ben Zhi ^a   Gong, Dong Mei ^a   Liu, Yu ^a   Pan, Zhen Wei ^a   Xu, Chao Qian ^a   Bai, Yun Long ^a   Qiao, Guo Fen ^a   Lu, Yan Jie ^a   Yang, Bao Feng ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Atrial fibrillation; Homocysteine; Human atrial myocytes; Potassium current

Indexed keywords

HOMOCYSTEINE; INWARDLY RECTIFYING POTASSIUM CHANNEL; POTASSIUM CHANNEL;

ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HEART ATRIUM FIBRILLATION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; PATCH CLAMP; POTASSIUM CURRENT; RISK FACTOR;

ATRIAL FIBRILLATION; DELAYED RECTIFIER POTASSIUM CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART ATRIA; HOMOCYSTEINE; HUMANS; KINETICS; MEMBRANE POTENTIALS; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, INWARDLY RECTIFYING;

EID: 34447527362     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04671.x     Document Type: Article

References (28)

1. Nowak M, Swietochowska E, Wielkoszynski T et al. Homocysteine, vitamin B12, and folic acid in age-related macular degeneration. Eur. J. Ophthalmol. 2005 15 : 764 7.
2. Majors A, Ehrhart LA, Pezacka EH. Hcy as a risk factor for vascular disease. Arterioscler. Thromb. Vasc. Biol. 1997 17 : 2074 81.
3. Majors AK, Sengupta S, Willard B. Hcy binds to human plasma fibronectin and inhibits its interaction with fibrin. Arterioscler. Thromb. Vasc. Biol. 2002 22 : 1354 9.
4. Fowler B. Homocystein: An independent risk factor for cardiovascular and thrombotic diseases. Ther. Umsch. 2005 62 : 641 6.
5. Sun T, Wang XF. The relationship between Hcy, high sensitive C-reactive protein and atrial fibrillation. Zhejiang Pract. Med. 2006 11 : 145 6.
6. Marcucci R, Betti I, Cecchi E et al. Hyperhomocysteinemia and vitamin B6 deficiency: New risk markers for nonvalvular atrial fibrillation. Am. Heart J. 2004 48 : 456 61.
7. Van Wagoner DR. Electrophysiological remodeling in human atrial fibrillation. Pacing Clin. Electrophysiol. 2003 26 : 1572 5.
8. Bosch RF, Zeng X, Grammer JB, Popovic K, Mewis C, Kuhlkamp V. Ionic mechanisms of electrical remodeling in human atrial fibrillation. Cardiovasc. Res. 1999 44 : 121 31.
9. Zhang H, Garratt CJ, Zhu J, Holden AV. Role of up-regulation of IK1 in action potential shortening associated with atrial fibrillation in humans. Cardiovasc. Res. 2005 6 : 493 502.
10. Feng JL, Wang Z, Li GR, Nattel S. Effects of class III antiarrhythmic drugs on transient outward and ultra-rapid delayed rectifier currents in human atrial myocytes. J. Pharmacol. Exp. Ther. 1997 281 : 384 92.
11. Wang Z, Fermini B, Nattel S. Sustained depolarization-induced outward current in human atrial myocytes. Evidence for a novel delayed rectifier K+ current similar to Kv1.5 cloned channel currents. Circ. Res. 1993 73 : 1061 76.
12. Wang Z, Fermini B, Nattel S. Rapid and slow components of delayed rectifier current in human atrial myocytes. Cardiovasc. Res. 1994 281 : 1540 6.
13. Yang BF, Luo DL, Bao LH, Zhang YC, Wang HZ. Artemisinin blocks activating and slowly activating K+ current in guinea pig ventricular myocytes. Acta Pharmacol. Sin. 1998 19 : 269 72.
14. Dong DL, Liu Y, Zhou YH, Song WH, Wang H, Yang BF. Decreases of voltage-dependent K+ currents densities in ventricular myocytes of guinea pigs by chronic oxidant stress. Acta Pharmacol. Sin. 2004 25 : 751 5.
15. Pacher P, Ungvari Z, Kecskemeti V. Electrophysiological effects of Hcy in isolated rat right ventricular papillary muscles and left atria. Gen. Pharmacol. 1999 32 : 439 43.
16. Shontz RD, Xu Z, Patel KP, Rozanski GJ. Inhibition of K+ currents by homocysteine in rat ventricular myocytes. J. Cardiovasc. Electrophysiol. 2001 12 : 175 82.
17. Gao Z, Sun H, Chiu SW, Lau CP, Li GR. Effects of diltiazem and nifedipine on transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes. Br. J. Pharmacol. 2005 144 : 595 604.
18. Yang BF, Li GR, Xu CQ, Nattel S. Effects of RP58866 on transmembrane K+ currents in mammalian ventricular myocytes. Acta Pharmacol. Sin. 1999 20 : 961 9.
19. Akar FG, Wu RC, Juang GJ et al. Molecular mechanisms underlying K+ current downregulation in canine tachycardia-induced heart failure. Am. J. Physiol. Heart Circ. Physiol. 2005 288 : H2887 96.
20. Cha TJ, Ehrlich JR, Zhang L, Nattel S. Atrial ionic remodeling induced by atrial tachycardia in the presence of congestive heart failure. Circulation 2004 110 : 1520 6.
21. Van Wagoner DR, Pond AL, McCarthy PM, Trimmer JS, Nerbonne JM. Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation. Circ. Res. 1997 80 : 772 81.
22. Grammer JB, Bosch RF, Kuhlkamp V, Seipel L. Molecular remodeling of Kv4.3 potassium channels in human atrial fibrillation. J. Cardiovasc. Electrophysiol. 2000 1 : 626 33.
23. Zygmunt AC, Goodrow RJ, Antzelevitch C. Sodium effects on 4-aminopyridine-sensitive transient outward current in canine ventricular cells. Am. J. Physiol. 1997 272 : H1 11.
24. Zhang ZH, Boutjdir M, el-Sherif N. Ketanserin inhibits depolarization-activated outward potassium current in rat ventricular myocytes. Circ. Res. 1994 75 : 711 21.
25. Dhamoon AS, Jalife J. The inward rectifier current (IK1) controls cardiac excitability and is involved in arrhythmogenesis. Heart Rhythm 2005 2 : 316 24.
26. Li GR, Lau CP, Leung TK, Nattel S. Ionic current abnormalities associated with prolonged action potentials in cardiomyocytes from diseased human right ventricles. Heart Rhythm 2004 1 : 460 8.
27. Li J, McLerie M, Lopatin AN. Transgenic up-regulation of IK1 in the mouse heart leads to multiple abnormalities of cardiac excitability. Am. J. Physiol. Heart Circ. Physiol. 2004 287 : H2790 802.
28. Yang B, Lin H, Xiao J et al. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat. Med. 2007 13 : 486 91.