Preparation of both enantiomers of a synthon for novel nucleoside analogs by enzymatic desymmetrization of a meso-diol with a methylene cyclopropane skeleton

Tetrahedron Letters

Volumn 52, Issue 10, 2011, Pages 1082-1085

  Obame, Germain ^a   Pellissier, Hélne ^a   Vanthuyne, Nicolas ^a   Bongui, Jean Bernard ^b   Audran, Gérard ^a  

^a AIX MARSEILLE UNIVERSITÉ   (France)

^b UNIVERSITÉ DES SCIENCES ET TECHNIQUES DE MASUKU   (Gabon)

Author keywords

Biocatalysis; Carbocyclic nucleosides; Chiral building blocks; Enzymatic desymmetrization; Methylene cyclopropane

Indexed keywords

ACETIC ACID 2 HYDROXYMETHYL 3 METHYLENECYCLOPROPYLMETHYL ESTER; CARBENE; CYCLOPROPANE DERIVATIVE; DIOXEPIN; ESTER DERIVATIVE; HYDROLASE; METHYLCHLOROCARBENE; METHYLENECYCLOPROPANE DIOL; NUCLEOSIDE ANALOG; ORGANIC SOLVENT; OXEPINE DERIVATIVE; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; CYCLOADDITION; DESYMMETRIZATION; ENANTIOMER; ENANTIOSELECTIVITY; OPTICAL ROTATION; RACEMIZATION; STEREOCHEMISTRY; TRANSESTERIFICATION; X RAY ANALYSIS;

EID: 79551689306     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.12.097     Document Type: Article

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