Asymmetrization of 2-methylpropane-1,3-diol by Mucor miehei lipase-catalyzed benzoylation in organic solvent

Tetrahedron Asymmetry

Volumn 15, Issue 20, 2004, Pages 3177-3179

  Santaniello, Enzo ^a   Casati, Silvana ^a   Ciuffreda, Pierangela ^a   Gamberoni, Luca ^a  

^a Dipto Sci Precliniche LITA V   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 PROPANEDIOL; 2 METHYLPROPANE 1,3 DIOL; BENZOIC ACID; ORGANIC SOLVENT; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; VINYL BENZOATE;

ACYLATION; ARTICLE; CATALYSIS; CHEMICAL PROCEDURES; CHIRALITY; ENANTIOMER; MUCOR; MUCOR MEIHEI; PRIORITY JOURNAL;

EID: 5144232962     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetasy.2004.09.005     Document Type: Article

References (23)

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13. D = +4.9 (c 1, MeOH)
14. 3)
15. In Ref. 8 it has been reported that the specific rotation of (S)-(+)-2b prepared by enzymatic resolution of (RS)-2b was +2.1 (c 1, MeOH, 84% ee), whereas for a sample of (R)-(-)-2b it was assumed to be 98% enantiomerically with a specific rotation of -2.5 (c 1, MeOH)
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21. 6
22. 12
23. D = +7.9 (c 1, MeOH). A >98% ee was established by the NMR spectrum of MTPA derivative that showed no signal corresponding to (R)-2b