Bone-marrow-derived macrophages genetically modified to produce IL-10 reduce injury in experimental glomerulonephritis

Molecular Therapy

Volumn 6, Issue 6, 2002, Pages 710-717

  Wilson, Heather M ^a   Stewart, Keith N ^b   Brown, Paul A J ^b   Anegon, Ignacio ^c   Chettibi, Salah ^a   Rees, Andrew J ^a   Kluth, David C ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c Inst Natl de la Recherche   (France)

Author keywords

Adenovirus; Autoimmunity; Contralateral effect; Gene therapy; IL 10; Inflammation; Macrophage; Nephrotoxic nephritis

Indexed keywords

BIOLOGICAL MARKER; GAMMA INTERFERON; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; SIALOADHESIN; TUMOR NECROSIS FACTOR ALPHA;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CELL COUNT; CELL CULTURE; CELL INFILTRATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; DNA MODIFICATION; GENE DELIVERY SYSTEM; GENETIC TRANSDUCTION; GLOMERULONEPHRITIS; IMMUNE COMPLEX NEPHRITIS; INFLAMMATORY DISEASE; KIDNEY FIBROSIS; KIDNEY INJURY; MACROPHAGE; NONHUMAN; NULL ALLELE; PROTEIN EXPRESSION; PROTEINURIA; RAT; RENAL ARTERY; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALIA;

EID: 0036941189     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2002.0802     Document Type: Article

References (35)

1. Moore, K. W., de Waal Malefyt, R., Coffman, R. L., and O'Garra, A. (2001). Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19: 683-765.
2. Fedorak, R. N., et al. (2000). Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group. Gastroenterology 119: 1473-1473.
3. McInnes, I. B., et al. (2001). IL-10 improves skin disease and modulates endothelial activation and leukocyte effector function in patients with psoriatic arthritis. J. Immunol. 167: 4075-4082.
4. Chen, W. F., and Zlotnik, A. (1991). IL-10: A novel cytotoxic T cell differentiation factor. J. Immunol. 147: 528-534.
5. Rousset, F., et al. (1992). Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc. Natl. Acad. Sci. USA 89: 1890-1893.
6. Pennline, K. J., Roque-Gaffney, E., and Monohan, M. (1994). Recombinant human IL-10 prevents the onset of diabetes in the non-obese diabetic mouse. Clin. Immunol. Immunopathol. 71: 161-175.
7. Walmsey, M., et al. (1996). Interleukin-10 inhibition of the progression of established collagen-induced arthritis. Arthritis Rheum. 39: 495-503.
8. Lee, M., Mueller, S. R., Wicker, L. S., Peterson, L. B., and Starvetnick, N. (1996). IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity. J. Exp. Med. 183: 2663-2668.
9. Cohen, S. B., et al. (1995). High level of interleukin-10 production by the activated T cell population within the rheumatoid synovial membrane. Arthritis Rheum. 38: 946-952.
10. Cua, D. J., Hutchins, B., LaFace, D. M., Stohlman, S. A., and Coffman, R. L. (2001). Central nervous system expression of IL-10 inhibits autoimmune encephalomyelitis. J. Immunol. 166: 602-608.
11. Setoguchi, K., et al. (2000). Antigen-specific T cells transduced with IL-10 ameliorate experimentally induced arthritis without impairing the systemic immune response to the antigen. J. Immunol. 165: 5980-5986.
12. Moritani, M., et al. (1996). Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th 1 lymphocytes. A gene therapy model for autoimmune diabetes. J. Clin. Invest. 98: 1851-1859.
13. Kitching, A. R., Tipping, P. G., Timoshanko, J. R., and Holdsworth, S. R. (2000). Endogenous interleukin-10 regulates Th1 responses that induce crescentic glomerulonephritis. Kidney Int. 57: 518-525.
14. Kitching, A. R., Tipping, P. G., Huang X. R., Mutch, D. A., and Holdsworth, S. R. 1997. Interleukin-4 and interleukin-10 attenuate established crescentic glomerulonephritis in mice. Kidney Int. 52: 52-59.
15. Chadban, S. J., Tesch, G. H., Lan, H. Y., Atkins, R. C., and Nikolic-Paterson, D. J. (1997). Effect of interleukin-10 treatment on crescentic glomerulonephritis in rats. Kidney Int. 51: 1809-1817.
16. Huang, X. R., Kitching, A. R., Tipping P. G., and Holdsworth, S. R. (2000). Interleukin-10 inhibits macrophage-induced glomerular injury. J. Am. Soc. Nephrol. 11: 262-269.
17. Kluth, D. C., Erwig, L. P., and Rees, A. J. (2000). Gene transfer into inflamed glomeruli using macrophages transfected with adenovirus. Gene Ther. 7: 263-270.
18. Kluth, D. C., et al. (2001). Macrophages transfected with adenovirus to express IL-4 reduce inflammation in experimental glomerulonephritis. J. Immunol. 166: 4728-4736.
19. Erwig, L. P., Kluth, D. C., Walsh, G. M., and Rees, A. J. (1998). Initial cytokine exposure determines macrophage function and renders them unresponsive to other cytokines. J. Immunol. 161: 1983-1988.
20. Dijkstra, C. D., Dopp, E. A., and Joling, P. (1985). The heterogeneity of mononuclear phagocytes in lymphoid organs: Distinct macrophage subpopulations in the rat recognised by monoclonal antibodies ED1, ED2 and ED3. Immunology 54: 589-599.
21. Lechman, E. R., et al. (1999). Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees. J. Immunol. 163: 2202-2208.
22. Whalen, J. D., et al. (1999). Adenoviral transfer of viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws. J. Immunol. 16: 3625-3632.
23. DiAmico, G., et al. (2000). Uncoupling of inflammatory chemokine receptors by IL-10: Generation of functional decoys. Nat. Immunol. 1: 387-391.
24. Takayama, T. I., et al. (2001). Mammalian and viral IL-10 enhances C-C chemokine receptor 5 but down-regulates C-C chemokine receptor 7 expression by myeloid dendritic cells: Impact on chemotactic responses and in vivo homing ability. J. Immunol. 166: 7136-7143.
25. Dieu-Nosjean, M. C., Massacrier, C., Vanbervliet, B., Fridman, W.-H., and. Caux, C. (2001). IL-10 induces CCR6 expression during Langerhans cell development while IL-4 and IFN-γ suppress it. J. Immunol. 167: 5594-5602.
26. Groux, H., and Powrie, F. (1999). Regulatory T cells and inflammatory bowel disease. Immunol. Today. 20: 442-445.
27. Kim, K. H., Kin, S., Evans, C. H., Ghivizzani, S. C., Oligino, T., and Robbins, P. D. (2001). Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4. J. Immunol. 166: 3505-3505.
28. Morita, Y., et al. (2001). Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. J. Clin. Invest. 107: 1275-1284.
29. Yokoo, T., et al. (2001). Genetically modified bone marrow continuously supplies anti-inflammatory cells and suppresses renal injury in mouse Goodpasture syndrome. Blood 98: 57-64.
30. Yamagishi, H., Yokoo, T., Toshiyuki, I., Mitarai, T., Kawamura, T., and Utsunomiya, Y. (2001). Genetically modified bone marrow-derived vehicle cells site specifically deliver an anti-inflammatory cytokine to inflamed interstitium of obstructive nephropathy. J. Immunol. 166: 609-616.
31. Ghivizzani, S. C., et al. (1998). Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor α soluble receptors to rabbit knees with experimental arthritis has local and distal antiarthritic effects. Proc. Natl. Acad. Sci. USA 95: 4613-4618.
32. Whalen, J. D., Thomson, A. W., Lu, L., Robbins, P. D., and Evans, C. H. (2001). Viral IL-10 gene transfer inhibits DTH responses to soluble antigens: Evidence for involvement of genetically modified dendritic cells and macrophages. Mol. Ther. 6: 543-550.
33. David, A., et al. (1997). Adenovinus-mediated gene transfer in rat liver of interleukin 4 but not interleukin 10 produces severe acute hepatitis. Cytokine 11: 818-829.
34. David, A., et al. (1998). Anti-adenovirus immune responses in rats are enhanced by interleukin 4 but not interleukin 10 produced by recombinant adenoviruses. Hum. Gene Ther. 12: 1755-1768.
35. Graham, F., and Prevec, L. (1991). Manipulation of adenovirus vectors. In Methods in Molecular Biology: Gene Transfer and Expression Protocols (E. J. Murray and N. J. Clifton, Eds.), pp. 109-128. Humana Press, Clifton, NJ.