The effect of fenugreek on the gene expression of arachidonic acid metabolizing enzymes

Phytotherapy Research

Volumn 25, Issue 2, 2011, Pages 221-227

  Varjas, Timea ^a   Nowrasteh, Ghodratollah ^a   Budán, Ferenc ^a   Horváth, Gábor ^a   Cseh, Jõzsef ^b   Gyöngyi, Zoltán ^a   Makai, Sándor ^c   Ember, István ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

^b Szent Gyorgy Hospital   (Hungary)

^c UNIVERSITY OF WEST HUNGARY   (Hungary)

Author keywords

chemoprevention; cyclooxygenase; fenugreek; gene expression; lipoxygenase

Indexed keywords

ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONATE OMEGA 6 LIPOXYGENASE; ARACHIDONIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DIMETHYLBENZ[A]ANTHRACENE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LIPOXYGENASE; MESSENGER RNA; TRIGONELLA FOENUM GRAECUM EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; FENUGREEK; GENE EXPRESSION; KIDNEY PARENCHYMA; LIVER; LUNG PARENCHYMA; MOUSE; NONHUMAN; PLANT SEED; SPLEEN;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ARACHIDONATE LIPOXYGENASES; ARACHIDONIC ACID; CARCINOGENS; CYCLOOXYGENASE 1; FEMALE; GENE EXPRESSION REGULATION; KIDNEY; LIVER; LUNG; MEMBRANE PROTEINS; MICE; MICE, INBRED AKR; PLANT EXTRACTS; SPLEEN; TRIGONELLA;

MUS; TRIGONELLA FOENUM-GRAECUM;

EID: 79551668967     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3231     Document Type: Article

References (27)

1. Aggarwal BB, Shishodia S., 2006. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71: 1397-1421.
2. Amin A, Alkaabi A, Al-Falasi S, Daoud SA., 2005. Chemopreventive activities of Trigonella foenum graecum (Fenugreek) against breast cancer. Cell Biol Int 29: 687-694.
3. Anderson KM, Seed T, Vos M, et al,. 1998. 5-Lipoxygenase inhibitors reduce PC-3 cell proliferation and initiate nonnecrotic cell death. Prostate 37: 161-173.
4. Bengmark S., 2006. Curcumin, an atoxic antioxidant and natural NFÎ?B, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases. J Parenter Enteral Nutr 30: 45-51.
5. Bhatia K, Kaur M, Atif F, et al,. 2006. Aqueous extract of Trigonella foenum-graecum L. ameliorates additive urotoxicity of buthionine sulfoximine and cyclophosphamide in mice. Food Chem Toxicol 44: 1744-1750.
6. Brink C, Dahlén SE, Drazen J, et al,. 2004. International Union of Pharmacology XLIV. Nomenclature for the Oxoeicosanoid Receptor. Pharmacol Rev 56: 149-157.
7. Burnett BP, Jia Q, Zhao Y, Levy RM., 2007. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. J Med Food 10: 442-451.
8. Corbiere C, Liagre B, Bianchi A, et al,. 2003. Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin and tigogenin, on human 1547 osteosarcoma cells. Int J Oncol 22: 899-905.
9. Devasagayam TPA, Sainis KB., 2002. Immune system and antioxidants, especially those derived from Indian medicinal plants. Indian J Exp Biol 40: 639-655.
10. Ghosh J, Myers CE., 1997. Arachidonic acid stimulates prostate cancer cell growth: critical role of 5-lipoxygenase. Biochem Biophys Res Commun 235: 418-423.
11. Glasgow WC, Afshari CA, Barrett JC, Eling TE., 1992. Modulation of the epidermal growth factor mitogenic response by metabolites of linoleic and arachidonic acid in Syrian hamster embryo fibroblasts. Differential effects in tumor suppressor gene (+) and (-) phenotypes. J Biol Chem 267: 10771-10779.
12. Gupta S, Srivastava M, Ahmad N, Sakamoto K, Bostwick DG, Mukhtar H., 2001. Lipoxygenase-5 is overexpressed in prostate adenocarcinoma. Cancer (Phila) 91: 737-743.
13. Hibasami H, Moteki H, Ishikawa K, et al,. 2003. Protodioscin isolated from fenugreek (Trigonella foenum graecum L.) induces cell death and morphological change indicative of apoptosis in leukemic cell line H-60, but not in gastric cancer cell line KATO III. Int J Mol Med 11: 23-26.
14. Janakiram NB, Rao CV., 2008. Molecular markers and targets for colorectal cancer prevention. Acta Pharmacol Sin 29: 1-20.
15. Li N, Sood S, Wang S, et al,. 2005. Overexpression of 5-lipoxygenase and cyclooxygenase 2 in hamster and human oral cancer and chemopreventive effects of zileuton and celecoxib. Clin Cancer Res 11: 2089-2096.
16. Lin JK., 2007. Molecular targets of curcumin. Adv Exp Med Biol 595: 227-243.
17. Moalic S, Liagre B, CorbiÃ?re C, et al,. 2001. A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells. FEBS Lett 506: 225-230.
18. Noor EA., 2008. Comparative study on the corrosion inhibition of mild steel by aqueous extract of fenugreek seeds and leaves in acidic solutions. J Eng Appl Sci 3: 23-30.
19. Norton SA., 1998. Useful plants of dermatology. III. Corticosteroids, strophanthus, and dioscorea. J Am Acad Dermatol 38: 256-259.
20. O'Neill GP, Ford-Hutchinson AW., 1993. Expression of RNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett 330: 156-160.
21. Perjési P, Gyöngyi Z, Bayer Z., 2000. Effect of E-2-(4′-methoxybenzylidene)-1-benzosuberone on the 7,12-dimethylbenz[a] anthracene-induced onco/suppressor gene action in vivo II: A 48-hour experiment. Anticancer Res 20: 1839-1848. (Pubitemid 30628210)
22. Raju J, Patlolla JM, Swamy MV, Rao CV., 2004. Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells. Cancer Epidemiol Biomarkers Prev 13: 1392-1398.
23. Shishodia S, Aggarwal BB., 2006. Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression. Oncogene 25: 1463-1473.
24. Shureiqi I, Lippman SM., 2001. Lipoxygenase modulation to reverse carcinogenesis. Cancer Res 61: 6307-6312.
25. Sur P, Das M, Gomes A, et al,. 2001. Trigonella foenum graecum (Fenugreek) seed extract as an antineoplastic agent. Phytother Res 15: 257-259.
26. Tang K, Honn KV., 1999. 12(S)-HETE in cancer metastasis. Adv Exp Med Biol 447: 181-191.
27. Timar J, Raso E, Dome B, et al,. 2000. Expression, subcellular localization and putative function of platelet type 12-lipoxygenase in human prostate cancer cell lines of different metastatic potential. Int J Cancer 87: 37-43.