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Volumn 8, Issue 1, 2011, Pages 134-144

Syntheses of dehydroaltenusin, a selective inhibitor of mammalian DNA polymerase α

Author keywords

Anti cancer drug; Dehydroaltenusin; DNA polymerase ; Enzyme inhibitor; Structure activity relationship

Indexed keywords


EID: 79551651830     PISSN: 15701794     EISSN: None     Source Type: Journal    
DOI: 10.2174/157017911794407674     Document Type: Article
Times cited : (1)

References (32)
  • 2
    • 0013164970 scopus 로고
    • Metabolites of some Alternaria species. The structures of altenusin and dehydroaltenusin
    • Coombe, R. G.; Jacobs, J. J.; Watson, T. R. Metabolites of some Alternaria species. The structures of altenusin and dehydroaltenusin. Aust. J. Chem. 1970, 23, 2343-2351.
    • (1970) Aust. J. Chem , vol.23 , pp. 2343-2351
    • Coombe, R.G.1    Jacobs, J.J.2    Watson, T.R.3
  • 5
    • 0025633397 scopus 로고
    • The metabolites of Talaromyces flavus: Part 1. Metabolites of the organic extracts
    • Ayer, W. A.; Racok, J. S. The metabolites of Talaromyces flavus: Part 1. Metabolites of the organic extracts. Can. J. Chem. 1990, 68, 2085-2094.
    • (1990) Can. J. Chem. , vol.68 , pp. 2085-2094
    • Ayer, W.A.1    Racok, J.S.2
  • 6
    • 0345650259 scopus 로고
    • An alternative structure for bortrallin a metabolite of Botrytis allii
    • Kameda, K.; Aoki, H.; Namiki, M.; Overeem, J. C. An alternative structure for bortrallin a metabolite of Botrytis allii. Tetrahedron Lett. 1974, 12, 103-106.
    • (1974) Tetrahedron Lett. , vol.12 , pp. 103-106
    • Kameda, K.1    Aoki, H.2    Namiki, M.3    Overeem, J.C.4
  • 7
    • 0029339184 scopus 로고
    • Isolation of myosin light chain kinase inhibitors from microorganisms: Dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur
    • Nakanishi, S.; Toki, S.; Saitoh, Y.; Tsukuda, E.; Kawahara, K.; Ando, K.; Matsuda, Y. Isolation of myosin light chain kinase inhibitors from microorganisms: dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur. Biosci. Biotech. Biochem. 1995, 59, 1333-1335.
    • (1995) Biosci. Biotech. Biochem. , vol.59 , pp. 1333-1335
    • Nakanishi, S.1    Toki, S.2    Saitoh, Y.3    Tsukuda, E.4    Kawahara, K.5    Ando, K.6    Matsuda, Y.7
  • 8
    • 0033388197 scopus 로고    scopus 로고
    • Anti-HIV activity of dehydroaltenusin-a metabolite from a Streptomyces sp
    • Jabbar, A.; Shresta, A. P.; Hasan, C. M.; Rashid, M. A. Anti-HIV activity of dehydroaltenusin-a metabolite from a Streptomyces sp. Nat. Prod. Sci. 1999, 5, 162-164.
    • (1999) Nat. Prod. Sci. , vol.5 , pp. 162-164
    • Jabbar, A.1    Shresta, A.P.2    Hasan, C.M.3    Rashid, M.A.4
  • 12
    • 67650401635 scopus 로고    scopus 로고
    • The in vitro and in vivo inhibitory effect of dehydroaltenusin: A specific inhibitor of mammalian DNA polymerase α
    • Maeda, N.; Kamisuki, S.; Takahashi, S.; Yoshida, H.; Sakaguchi, K.; Sugawara, F.; Mizushina, Y. The in vitro and in vivo inhibitory effect of dehydroaltenusin: A specific inhibitor of mammalian DNA polymerase α. Curr. Bioact. Comp. 2006, 2, 3-11.
    • (2006) Curr. Bioact. Comp. , vol.2 , pp. 3-11
    • Maeda, N.1    Kamisuki, S.2    Takahashi, S.3    Yoshida, H.4    Sakaguchi, K.5    Sugawara, F.6    Mizushina, Y.7
  • 15
    • 41949120825 scopus 로고    scopus 로고
    • A facile method to screen inhibitors of protein-protein interactions including MDM2-p53 displayed on T7 phage
    • Ishi, K.; Sugawara, F. A facile method to screen inhibitors of protein-protein interactions including MDM2-p53 displayed on T7 phage. Biochem. Pharmacol. 2008, 75, 1743-1750.
    • (2008) Biochem. Pharmacol. , vol.75 , pp. 1743-1750
    • Ishi, K.1    Sugawara, F.2
  • 16
    • 70349388071 scopus 로고    scopus 로고
    • Chemistry and biology of mycotoxins and related fungal metabolites
    • Bräse, S.; Encinas, A.; Keck, J.; Nising, C. F. Chemistry and biology of mycotoxins and related fungal metabolites. Chem. Rev. 2009, 109, 3903-3990.
    • (2009) Chem. Rev. , vol.109 , pp. 3903-3990
    • Bräse, S.1    Encinas, A.2    Keck, J.3    Nising, C.F.4
  • 17
    • 77957017414 scopus 로고
    • An approach to biogenesis of dehydroaltenusin by enzymic oxidation
    • Kameda, K.; Namiki, M. An approach to biogenesis of dehydroaltenusin by enzymic oxidation. Chem. Lett. 1974, 265-266.
    • (1974) Chem. Lett. , pp. 265-266
    • Kameda, K.1    Namiki, M.2
  • 18
    • 37049079220 scopus 로고
    • Synthesis based on cyclohexadienes: Part 4. Novel synthesis of the 6-aryl-2,4-dimethoxybenzoates. Alternariol and methyl trimethylaltenusin
    • Kanakam, C. C.; Mani, N. S.; Subba Rao, G. S. R. Synthesis based on cyclohexadienes: Part 4. Novel synthesis of the 6-aryl-2,4-dimethoxybenzoates. Alternariol and methyl trimethylaltenusin. J. Chem. Soc. Perkin Trans. I 1990, 2233-2237.
    • (1990) J. Chem. Soc. Perkin Trans. , vol.1 , pp. 2233-2237
    • Kanakam, C.C.1    Mani, N.S.2    Subba Rao, G.S.R.3
  • 20
    • 0026548419 scopus 로고
    • Total syntheses of KS-501, KS-502, and their enantiomers
    • Dushin, R. G.; Danishefski, S. J. Total syntheses of KS-501, KS-502, and their enantiomers. J. Am. Chem. Soc. 1992, 114, 655-659.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 655-659
    • Dushin, R.G.1    Danishefski, S.J.2
  • 23
    • 0028262311 scopus 로고
    • Practical, large-scale synthesis of 2,2-dimethyl-5-hydroxy-4-oxo-benzo-1,4-dioxin
    • Hadfield, A.; Schweitzer, H.; Trova, M. P.; Green, K. Practical, large-scale synthesis of 2,2-dimethyl-5-hydroxy-4-oxo-benzo-1,4-dioxin. Synth. Commun. 1994, 24, 1025-1028.
    • (1994) Synth. Commun , vol.24 , pp. 1025-1028
    • Hadfield, A.1    Schweitzer, H.2    Trova, M.P.3    Green, K.4
  • 24
    • 0347052793 scopus 로고    scopus 로고
    • Palladium-catalyzed sequential alkylationalkenylation reactions: New three-component coupling leading to oxacycles
    • Pache, S.; Lautens, M. Palladium-catalyzed sequential alkylationalkenylation reactions: new three-component coupling leading to oxacycles. Org. Lett. 2003, 5, 4827-4830.
    • (2003) Org. Lett. , vol.5 , pp. 4827-4830
    • Pache, S.1    Lautens, M.2
  • 25
    • 68049142868 scopus 로고    scopus 로고
    • Total synthesis of dehydroaltenuene A. revision of the structure and total synthesis of dihydroaltenuene B
    • Altemöller, M.; Podlech, J. Total synthesis of dehydroaltenuene A. revision of the structure and total synthesis of dihydroaltenuene B. J. Nat. Prod. 2009, 72, 1288-1290.
    • (2009) J. Nat. Prod. , vol.72 , pp. 1288-1290
    • Altemöller, M.1    Podlech, J.2
  • 26
    • 0041350398 scopus 로고    scopus 로고
    • Stereoselective reactions of a (-)-quinic acid-derived enone: Application to the synthesis of the core of scyphostatin
    • Murray, L. M.; O'brien, P.; Taylor, R. J. K. Stereoselective reactions of a (-)-quinic acid-derived enone: Application to the synthesis of the core of scyphostatin. Org. Lett. 2003, 5, 1943-1946.
    • (2003) Org. Lett. , vol.5 , pp. 1943-1946
    • Murray, L.M.1    O'brien, P.2    Taylor, R.J.K.3
  • 29
    • 16844367937 scopus 로고    scopus 로고
    • Catalysts for SuzukiαMiyaura coupling processes: Scope and studies of the effect of ligand structure
    • Barder, T. E.; Walker, S. D.; Martinelli, J. R.; Buchwald, S. L. Catalysts for SuzukiαMiyaura coupling processes: Scope and studies of the effect of ligand structure. J. Am. Chem. Soc. 2005, 127, 4685-4696.
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 4685-4696
    • Barder, T.E.1    Walker, S.D.2    Martinelli, J.R.3    Buchwald, S.L.4
  • 30


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.