A facile method to screen inhibitors of protein-protein interactions including MDM2-p53 displayed on T7 phage

Biochemical Pharmacology

Volumn 75, Issue 9, 2008, Pages 1743-1750

  Ishi, Kazutomo ^a   Sugawara, Fumio ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Dehydroaltenusin; MDM2; Nutlin 3; p53; Phage display; Protein protein interaction

Indexed keywords

NUTLIN 3; PROTEIN MDM2; PROTEIN P53;

APOPTOSIS; ARTICLE; BACTERIOPHAGE T7; CELL CYCLE; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

BACTERIOPHAGE T7; CELL LINE, TUMOR; ESCHERICHIA COLI; HUMANS; IMIDAZOLES; PEPTIDE LIBRARY; PIPERAZINES; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTO-ONCOGENE PROTEINS C-MDM2; SMALL MOLECULE LIBRARIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 41949120825     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.01.020     Document Type: Article

References (23)

1. Rual J.F., Venkatesan K., Hao T., Hirozane-Kishikawa T., Dricot A., Li N., et al. Towards a proteome-scale map of the human protein-protein interaction network. Nature 437 (2005) 1173-1178
2. Legrain P., Wojcik J., and Gauthier J.M. Protein-protein interaction maps: a lead towards cellular functions. Trends Genet 17 (2001) 346-352
3. Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F.H., Goehler H., et al. A human protein-protein interaction network, a resource for annotating the proteome. Cell 122 (2005) 957-968
4. Legrain P., and Selig L. Genome-wide protein interaction maps using two-hybrid systems. FEBS Lett 480 (2000) 32-36
5. Sun Y. p53 and its downstream proteins as molecular targets of cancer. Mol Carcinog 45 (2006) 409-415
6. Vassilev L.T. p53 activation by small molecules: application in oncology. J Med Chem 48 (2005) 4491-4499
7. Lu Y., Coleska Z.N., Fang X., Gao W., Shangary S., Qiu S., et al. Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy. J Med Chem 49 (2006) 3759-3762
8. Kritzer J.A., Zutshi R., Cheah M., Ran F.A., Webman R., Wongjirad T.M., et al. Miniature protein inhibitors of the p53-hDM2 interaction. Chembiochem 7 (2006) 29-31
9. Vassilev L.T., Vu B.T., Graves B., Carvajal D., Podlaski F., Filipovic Z., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 (2004) 844-848
10. Moerke N.J., Aktas H., Chen H., Cantel S., Reibarkh M.Y., Fahmy A., et al. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell 128 (2007) 257-267
11. Smith G.P., and Petrenko V.A. Phage display. Chem Rev 97 (1997) 391-410
12. Rosenbaerg A., Griffin K., Studier F.W., McCormick M., Berg J., Novy R., and Mirendorf R. inNovations 6 (1996) 1-6
13. Krumpe L.R., Atkinson A.J., Smythers G.W., Kandel A., Schumacher K.M., McMahon J.B., et al. T7 lytic phage-displayed peptide libraries exhibit less sequence bias than M13 filamentous phage-displayed peptide libraries. Proteomics 6 (2006) 4210-4222
14. Jung S.O., Ro H.S., Kho B.H., Shin Y.B., Kim M.G., and Chung B.H. Surface plasmon resonance imaging-based protein arrays for high-throughput screening of protein-protein interaction inhibitors. Proteomics 5 (2005) 4427-4431
15. Morohashi K., Arai T., Saito S., Watanabe M., Sakaguchi K., and Sugawara F. A high-throughput phage display screening method using a combination of real-time PCR and affinity chromatography. Comb Chem High Throughput Screen 9 (2006) 55-61
16. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
17. Xie B., Tassi E., Swift M.R., McDonnell K., Bowden E.T., Wang S., et al. Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. J Biol Chem 281 (2005) 1137-1144
18. Morohashi K., Yoshino A., Yoshimori A., Saito S., Tanuma S., Sakaguchi K., et al. Identification of a drug target motif: an anti-tumor drug NK109 interacts with a PNxxxxP. Biochem Pharmacol 70 (2005) 37-46
19. Zondlo S.C., Lee A.E., and Aondlo N.J. Determinants of specificity of MDM2 for the activation domains of p53 and p65 proline27 disrupts the MDM-binding motif of p53. Biochemistry 45 (2006) 11945-11957
20. Murakami-Nakai C., Maeda N., Yonezawa Y., Kuriyama I., Kamisuki S., Takahashi S., et al. The effects of dehydroaltenusin, a novel mammalian DNA polymerase alpha inhibitor, on cell proliferation and cell cycle progression. Biochim Biophys Acta 1674 (2004) 193-199
21. Maeda N., Kokai Y., Ohtani S., Sahara H., Kuriyama I., Kamisuki S., et al. Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha. Biochem Biophys Res Commun 352 (2007) 390-396
22. Mizushina Y., Kamisuki S., Mizuno T., Takemura M., Asahara H., Linn S., et al. Dehydroaltenusin, a mammalian DNA polymerase alpha inhibitor. J Biol Chem 275 (2000) 33957-33961
23. Nakanishi S., Toki S., Saitoh Y., Tsukuda E., Kawahara K., Ando K., et al. Isolation of myosin light chain kinase inhibitors from microorganisms: dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur. Biosci Biotechnol Biochem 59 (1995) 1333-1335