Gene expression of growth signaling pathways is up-regulated in CD133-positive medulloblastoma cells

Oncology Letters

Volumn 2, Issue 2, 2011, Pages 357-361

  Gu, Chunyu ^a   Yokota, Naoki ^a,b   Gao, Yun ^a   Yamamoto, Junkoh ^a   Tokuyama, Tsutomu ^a   Namba, Hiroki ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Yokohama CyberKnife Center   (Japan)

Author keywords

Cancer initiating cells; Medulloblastoma; Prominin 1 antigen; Transcript analysis

Indexed keywords

CD133 ANTIGEN; CYCLIN D1; CYCLIN DEPENDENT KINASE 6; INHIBIN B; MYC PROTEIN; NEU DIFFERENTIATION FACTOR; PROMYELOCYTIC LEUKEMIA PROTEIN; TRANSCRIPTION FACTOR HES 1; VASCULOTROPIN;

ARTICLE; CANCER GROWTH; CANCER STEM CELL; CARCINOGENESIS; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION; HUMAN; HUMAN CELL; MEDULLOBLASTOMA; NUCLEOTIDE SEQUENCE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UNINDEXED SEQUENCE;

EID: 79551651124     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2011.235     Document Type: Article

References (37)

1. Louis DN, Ohgaki H, Wiestler OD and Cavenee WK (eds): WHO Classification of Tumours of the Central Nervous System. 4th edition. International Agency for Research on Cancer, Lyon, 2007.
2. Crawford JR, MacDonald TJ and Packer RJ: Medulloblastoma in childhood: new biological advances. Lancet Neurol 6: 1073-1085, 2007.
3. Clarke MF and Fuller M: Stem cells and cancer: two faces of eve. Cell 124: 1111-1115, 2006.
4. Singh SK, Hawkins C, Clarke ID, et al: Identification of human brain tumour initiating cells. Nature 432: 396-401, 2004.
5. Hemmati HD, Nakano I, Lazareff JA, et al: Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci USA 100: 15178-15183, 2003.
6. Miraglia S, Godfrey W, Yin AH, et al: A novel five-transmem- brane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning. Blood 90: 5013-5021, 1997.
7. Yu Y, Flint A, Dvorin EL and Bischoff J: AC133-2, a novel isoform of human AC133 stem cell antigen. J Biol Chem 277: 20711-20716, 2002.
8. Fargeas CA, Corbeil D and Huttner WB: AC133 antigen, CD133, prominin-1, prominin-2, etc.: prominin family gene products in need of a rational nomenclature. Stem Cells 21: 506-508, 2003.
9. Mizrak D, Brittan M and Alison MR: CD133: molecule of the moment. J Pathol 214: 3-9, 2008.
10. -metastatic colon cancer cells initiate tumors. J Clin Invest 118: 2111-2120, 2008.
11. + sector is enlarged by hypoxia. Int J Radiat Oncol Biol Phys 67: 1-5, 2007.
12. Srivastava VK and Nalbantoglu J: Flow cytometric characterization of the DAOY medulloblastoma cell line for the cancer stem-like phenotype. Cytometry A 73: 940-948, 2008.
13. Buckbinder L, velasco-Miguel S, Chen Y, et al: The p53 tumor suppressor targets a novel regulator of G protein signaling. Proc Natl Acad Sci USA 94: 7868-7872, 1997.
14. Guarnaccia C, Pintar A and Pongor S: Exon 6 of human Jagged-1 encodes an autonomously folding unit. FEBS Lett 574: 156-160, 2004.
15. Gilbertson RJ, Clifford SC, MacMeekin W, et al: Expression of the ErbB-neuregulin signaling network during human cerebellar development: implications for the biology of medulloblastoma. Cancer Res 58: 3932-3941, 1998.
16. Takahashi K, Tanabe K, Ohnuki M, et al: Induction of pluri- potent stem cells from adult human fibroblasts by defined factors. Cell 131: 861-872, 2007.
17. Reya T and Clevers H: Wnt signalling in stem cells and cancer. Nature 434: 843-850, 2005.
18. Ruiz i Altaba A, Sanchez P and Dahmane N: Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat Rev Cancer 2: 361-372, 2002.
19. Gilbertson RJ: Medulloblastoma: signalling a change in treatment. Lancet Oncol 5: 209-218, 2004.
20. Brown CW, Houston-Hawkins DE, Woodruff TK and Matzuk MM: Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions. Nat Genet 25: 453-457, 2000.
21. Holash J, Maisonpierre PC, Compton D, et al: vessel cooption, regression, and growth in tumors mediated by angiopoietins and vEGF. Science 284: 1994-1998, 1999.
22. Garner CC, Tucker RP and Matus A: Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites. Nature 336: 674-677, 1988.
23. Julien JP, Grosveld F, Yazdanbaksh K, Flavell D, Meijer D and Mushynski W: The structure of a human neurofilament gene (NF-L): a unique exon-intron organization in the intermediate filament gene family Biochim Biophys Acta 909: 10-20, 1987.
24. Ango F, di Cristo G, Higashiyama H, Bennett V, Wu P and Huang ZJ: Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innerva- tion at purkinje axon initial segment. Cell 119: 257-272, 2004.
25. Wingate RJ: The rhombic lip and early cerebellar development. Curr Opin Neurobiol 11: 82-88, 2001.
26. Yuan W, Zhou L, Chen JH, Wu JY, Rao Y and Ornitz DM: The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Dev Biol 212: 290-306, 1999.
27. Lafarga M, Crespo P, Berciano MT, Andres MA and Leon J: Apolipoprotein E expression in the cerebellum of normal and hypercholesterolemic rabbits. Brain Res Mol Brain Res 21: 115-123, 1994.
28. Hallahan AR, Pritchard JI, Chandraratna RA, et al: BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. Nat Med 9: 1033-1038, 2003.
29. Gumireddy K, Sutton LN, Phillips PC and Reddy CD: All-trans- retinoic acid-induced apoptosis in human medulloblastoma: activation of caspase-3/poly(ADP-ribose) polymerase 1 pathway. Clin Cancer Res 9: 4052-4059, 2003.
30. Goodrich Lv, Milenkovic L, Higgins KM and Scott MP: Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277: 1109-1113, 1997.
31. Wechsler-Reya R and Scott MP: The developmental biology of brain tumors. Annu Rev Neurosci 24: 385-428, 2001.
32. Yokota N, Nishizawa S, Ohta S, et al: Role of Wnt pathway in medulloblastoma oncogenesis. Int J Cancer 101: 198-201, 2002.
33. Yokota N, Mainprize TG, Taylor MD, et al: Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization. Oncogene 23: 3444-3453, 2004.
34. Fan X, Matsui W, Khaki L, et al: Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res 66: 7445-7452, 2006.
35. Gilbertson R, Wickramasinghe C, Hernan R, et al: Clinical and molecular stratification of disease risk in medulloblastoma. Br J Cancer 85: 705-712, 2001.
36. MacDonald TJ, Brown KM, LaFleur B, et al: Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease. Nat Genet 29: 143-152, 2001.
37. Gilbertson RJ and Clifford SC: PDGFRB is overexpressed in metastatic medulloblastoma. Nat Genet 35: 197-198, 2003.