Lentiviral-mediated RNAi targeting p38MAPK ameliorates high glucose-induced apoptosis in osteoblast MC3T3-E1 cell line

Indian Journal of Experimental Biology

Volumn 49, Issue 2, 2011, Pages 94-104

  Feng, Zhengping ^a   Deng, Huacong ^a   Du, Jia ^a   Chen, Danyan ^a   Jiang, Rong ^a   Liang, Xiaoyan ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; High glucose; Lentivirus; Mc3t3 e1 cell line; P38mapk; Rna interference

Indexed keywords

GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE P38; SMALL INTERFERING RNA;

ANIMAL; APOPTOSIS; ARTICLE; CELL LINE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; EVALUATION; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; LENTIVIRINAE; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PHYSIOLOGY;

ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENETIC VECTORS; GLUCOSE; LENTIVIRUS; MICE; MOLECULAR SEQUENCE DATA; OSTEOBLASTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RNA, SMALL INTERFERING; TRANSFECTION;

LENTIVIRUS;

EID: 79551645941     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, March 7-29, 2000: Highlights of the conference, South Med J, 94 (2001) 569.
2. Raisz L G, Pathogenesis of osteoporosis: Concepts, conflicts, and prospects, J Clin Invest, 115 (2005) 3318.
3. Shaw J E, Sicree R A & Zimmet P Z, Global estimates of the prevalence of diabetes for 2010 and 2030, Diabetes Res Clin Pract, 87 (2010) 4.
4. Wild S, Roglic G, Green A, Sicree R & King H, Global prevalence of diabetes: estimates for the year 2000 and projections for 2030, Diabetes Care, 27 (2004) 1047.
5. Brown Sue A, Sharpless & Julie L, Osteoporosis: An underappreciated complication of Diabetes. Clinin diabetes 22 (2004)
6. Brigg Turner R, Mary Vagula & Sachin S Devi osteoporosis: An Understated complication of diabetes, US Pharm, 34 (2009) 14.
7. Angela M. Inzerillo & Solomon, Epstein, Osteoporosis and diabetes mellitus, Rev Endocr Metab Disord, 5 (2004) 261
8. Hofbauer L C, Brueck C C, Singh S K & Dobnig H, J Bone Miner Res, 22 (2007) 1317.
9. Vestergaard P, Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes-a meta-analysis, Osteoporos Int, 18 (2007) 427.
10. Nicodemus K K & Folsom A R, Iowa Women's Health Study, Type 1 and type 2 diabetes and incident hip fractures in postmenopausal women, Diabetes Care, 24 (2001) 1192.
11. Schwartz A V, Sellmeyer D E, Ensrud K E, Cauley J A, Tabor H K, Schreiner P J, Jamal S A, Black D M & Cummings S R, Study of osteoporotic features research group: Older women with diabetes have an increased risk of fracture: A prospective study J Clin Endocrinol Metab, 86 (2001) 32.
12. H, Liu R, Desta T, Leone C, Gerstenfeld L C & Graves D T, Diabetes causes decreased osteoclastogenesis, reduced bone formation, and enhanced apoptosis of osteoblastic cells in bacteria stimulated bone loss, Endocrinology,145 (2004) 447.
13. Alikhani M, Alikhani Z, Boyd C, MacLellan C M, Raptis M, Liu R, Pischon N, Trackman P C, Gerstenfeld L & Graves D T, Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways, Bone, 40 (2007) 345.
14. Gangoiti M V, Cortizo A M, Arnol V, Felice J I & McCarthy A D, Opposing effects of bisphosphonates and advanced glycation end-products on osteoblastic cells, Eur J Pharmacol, 600 (2008) 140.
15. Li Y M, Schilling T, Benisch P, Zeck S, Meissner-Weigl J, Schneider D, Limbert C, Seufert J, Kassem M, Schütze N, Jakob F & Ebert R, Effects of high glucose on mesenchymal stem cell proliferation and differentiation, Biochem Biophys Res Commun, 363 (2007) 209.
16. Zhen D, Chen Y & Tang X, Metformin reverses the deleterious effects of high glucose on osteoblast function, J Diabetes Complicat, 24 (2010) 334
17. Chae H J, Kim S C, Han K S, Chae S W, An N H, Kim H M, Kim H H, Lee Z H & Kim H R, Hypoxia induces apoptosis by caspase activation accompanying cytochrome C release from mitochondria in MC3T3E1 osteoblasts, p38MAPK is related in hypoxia-induced apoptosis, Immunopharmacol Immunotoxicol, 23 (2001) 133.
18. Yoon J H, Jeong A J, Kang K H & Kim S C, Role of p-38 MAP Kinase in apoptosis of hypoxia-induced osteoblasts, Korean J Orthod, 33 (2003) 169
19. Yun S I, Yoon H Y, Jeong S Y & Chung Y S, Glucocorticoid induces apoptosis of osteoblast cells through the activation of glycogen synthase kinase 3beta, J Bone Miner Metab, 27 (2009) 140.
20. Hsu S S, Huang C J, Cheng H H, Chou C T, Lee H Y, Wang J L, Chen I S, Liu S I, Lu Y C, Chang H T, Huang J K, Chen J S & Jan C R, Anandamide-induced Ca2+ elevation leading to p38 MAPK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells, Toxicology, 231 (2007) 21.
21. Chou C T, He S & Jan C R, Paroxetine-induced apoptosis in human osteosarcoma cells: activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca2+]ielevation, Toxicol Appl Pharmacol, 218 (2007) 265.
22. Igarashi M, Wakasaki H, Takahara N, Ishii H, Jiang Z Y, Yamauchi T, Kuboki K, Meier M, Rhodes C J & King G L, Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways, J Clin Invest,103 (1999) 185.
23. Du Y, Tang J, Li G, Berti-Mattera L, Lee C A, Bartkowski D, Gale D, Monahan J, Niesman M R, Alton G & Kern T S, Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function, Invest Ophthalmol Vis Sci, 51 (2010) 2158.
24. Nakagami H, Morishita R, Yamamoto K, Yoshimura S I, Taniyama Y, Aoki M, Matsubara H, Kim S, Kaneda Y & Ogihara T, Phosphorylation of p38 mitogen-activated protein kinase downstream of bax-caspase-3 pathway leads to cell death induced by high D-glucose in human endothelial cells, Diabetes, 50 (2001) 1472.
25. Kuki S, Imanishi T, Kobayashi K, Matsuo Y, Obana M & Akasaka T, Hyperglycemia accelerated endothelial progenitor cell senescence via the activation of p38 mitogenactivated protein kinase, Circ J, 70 (2006) 1076.
26. Larsen K I, Falany M L, Ponomareva L V, Wang W & Williams J P, Glucose-dependent regulation of osteoclast H(+)-ATPase expression: Potential role of p38 MAP-kinase, J Cell Biochem, 87 (2002) 75.
27. Zayzafoon M, Botolin S & McCabe LR, P38 and activating transcription factor-2 involvement in osteoblast osmotic response to elevated extracellular glucose, J Biol Chem, 277 (2002) 37212.
28. Brixen K T, Christensen P M, Ejersted C & Langdahl B L, Teriparatide (biosynthetic human parathyroid hormone 1-34): A new paradigm in the treatment of osteoporosis, Basic Clin Pharmacol Toxicol, 94 (2004) 260.
29. Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Yano S & Sugimoto T, Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes, Calcif Tissue Int, 85 (2009) 228.
30. Rane M J, Song Y, Jin S, Barati M T, Wu R, Kausar H, Tan Y, Wang Y, Zhou G, Klein J B, Li X & Cai L, Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy, Am J Physiol Renal Physiol, 298 (2010) F49.
31. Riad A, Unger D, Du J, Westermann D, Mohr Z, Sobirey M, Dorenkamp M, Schultheiss HP & Tschöpe C, Chronic inhibition of p38MAPK improves cardiac and endothelial function in experimental diabetes mellitus, Eur J Pharmacol, 554 (2007) 40.
32. Julia V Busik, L Karl Olson, Maria B Grant, & Douglas N Henry, Glucose-Induced Activation of Glucose Uptake in from the Inner and Outer Blood-Retinal Barrier, Invest Ophthalmol Vis Sci, 43 (2002) 2356.
33. Wiren K M, Toombs A R, Semirale A A & Zhang X, Osteoblast and osteocyte apoptosis associated with androgen action in bone: requirement of increased Bax/Bcl-2 ratio, Bone, 38 (2006) 637.
34. Haÿ E, Lemonnier J, Fromigué O & Marie P J Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad-independent, protein kinase C-dependent signaling pathway, J Biol Chem, 276 (2001) 29028.
35. Gronowicz G A, McCarthy M B, Zhang H & Zhang W, Insulin-like growth factor II induces apoptosis in osteoblasts, Bone, 35 (2004) 621.
36. Cércilie Dufour,Xavier Holy & Pierre J Marie Transforming growth factor-_ prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling, Am J Physiol Endocrinol Metab, 294 (2008) E794.
37. Qi J S, Li Y N, Zhang B S, Niu T & Liang J H, Peroxynitrite mediates high glucose-induced osteoblast apoptosis, J Endocrinol Invest, 31 (2008) 314.