Studies in drug albumin binding using hsa and rsa affinity methods

Journal of Liquid Chromatography and Related Technologies

Volumn 34, Issue 4, 2011, Pages 317-327

  Reilly, John ^a   Etheridge, Donnya ^a   Everatt, Brian ^a   Jiang, Zhengjin ^a   Aldcroft, Clive ^a   Wright, Penny ^a   Clemens, Ian ^a   Cox, Brian ^a   Press, Neil J ^a   Watson, Simon ^a   Porter, David ^a   Springer, Clayton ^b   Fairhurst, Robin A ^c  

^a NOVARTIS   (United Kingdom)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

gradient; high performance liquid chromatography; human serum albumin; plasma protein binding; rat serum albumin

Indexed keywords

GRADIENT; HIGH-THROUGHPUT APPROACHES; HUMAN SERUM ALBUMIN; HUMAN SERUM ALBUMINS; PLASMA PROTEIN BINDING; PROTEIN BINDING; QSAR MODEL; RANK ORDER; RAT SERUM; RAT SERUM ALBUMIN; STOCK SOLUTIONS; TREND ANALYSIS;

BIOCHEMISTRY; CHROMATOGRAPHY; COMPUTATIONAL CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; MOLECULAR GRAPHICS; PROTEINS;

BODY FLUIDS;

ALBUMINOID; BUDESONIDE; CARBAMAZEPINE; DICLOFENAC; DILTIAZEM; DIPHENHYDRAMINE; DOXEPIN; HUMAN SERUM ALBUMIN; IMIPRAMINE; KETOPROFEN; LABETALOL; NICARDIPINE; NORTRIPTYLINE; PROPRANOLOL; RAT SERUM ALBUMIN; UNCLASSIFIED DRUG; WARFARIN;

ARTICLE; BINDING AFFINITY; DRUG PROTEIN BINDING; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STEREOCHEMISTRY;

RATTUS;

EID: 79551637147     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826076.2011.548299     Document Type: Article

References (18)

1. Benez, L. Z.; Kroetz, D. L.; Sheiner, L. B. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed.; McGraw-Hill: NewYork, 1996, p 10.
2. Talbert, A.; Tranter, G. E.; Holmes, E.; Francis, P. L. Determination of Drug-Plasma Protein Binding Kinetics and Equilibria by Chromatographic Profiling: Exemplification of the Method Using L-Tryptophan and Albumin. Anal. Chem. 2002, 74, 446-452.
3. Trainor, G. L. The Importance of Plasma Protein Binding in Drug Discovery. Expert Opin. Drug Discov. 2007, 2 (1), 51-64.
4. Naranjo, C. A.; Sellers, E. M. Drug-Protein Binding, Paeger: New York, 1986; pp 233-251.
5. Takahashi, H.; Ogata, H.; Kanno, S.; Takeuchi, H. Plasma Protein Binding ofPropranolol Enantio-mers as a Major Determinant of Their Stereoselective Tissue Distribution in Rats. J. Pharm. Experim. Therapeut. Chem. 1990, 252 (1), 272-278.
6. Fitos, I.; Visy, J.; Kardos, J. Stereoselective Kinetics of Warfarin Binding to Human Serum Albumion: Effect of an Allosteric Interaction. Chirality 2002, 14, 442-448.
7. Chuang, V. T. G.; Otagiri, M. Stereoslective Binding of Human Serum Albumin. Chirality. 2006, 18, 159-166.
8. Pistolozzi, M.; Bertucci, C. Species-Dependant Steroselective Drug Binding to Albumin: A Circular Dichroism Study. Chirality. 2008, 20, 552-558.
9. Lin, J. H.; Deluna, F.; Ulm, E. H.; Tocco, D. J. Species-Dependant Enatioselective Plasma Protein Binding of MK-571, A Potent Leukotriene D4 Anatgonist. Drug Metabol. Disposit. 1990, 18 (4), 484-487.
10. Endo, H.; Yoshida, H.; Hasegawa, M.; Ohmi, N.; Horiuchi, N.; Hamada, Y; Higuchi, S. BiolPharm Bull. 2001, 24 (7), 800-805.
11. Noctor, T. G.; Diaz-Perez, M. J.; Wainer, I. W. Use of a Human Serum Albumin-based Stationary Phase for High-performance Liquid Chromatography as a Tool for the Rapid Determination of Drug-plasma Protein Binding. J. Pharma. Sci. 1993, 82 (6), 675-676.
12. Massolini, G.; DeLorenzi, E. D.; Ponci, M. C; Caccialanza, G. Comparison of Drug Binding Sites on Rat and Human Serum Albumins Using Immobilized-Protein Stationary Phases as a Toll for the Selection of Suitable Animal Models in Pharmacological Studies. Bolettino Chimico Farmaceutico. 1996, 135 (6), 382-386.
13. Singh, S. S.; Mehta, J. Measurement of Drug-Protein Binding by Immobilized Human Serum Albumin-HPLC and Comparison with Ultracentrifugation. J. Chromatogr. B 2005, 834, 108-116.
14. Valko, K; Nunhuck, S.; Bevan, C; Abraham, M. H.; Reynolds, D. P. Fast gradient HPLC Method to Determine Compounds Binding to Human Serum Albumin. Relationships with Octanol/Water and ImmobilizedArtificial Membrane Lipophilicity. J. Pharm. Sci. 2003, 92 (11), 2236-2248.
15. Kiyomi, I.; Houston, B. Comparison of the use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Datafrom Hepatic Microsomes and Isolated Hepatocytes. Pharma. Res. 2001, 21 (5), 785-792.
16. Jiang, Z.; Reilly, J.; Everatt, B. A Method for Rapidly Predicting Drug Tissue Distribution Using Surfactant Vesicle Chromatography. Electrophoresis 2008, 29, 3674-3684.
17. Goodman Gilman, A.; Hardman,J. G.; Limbard, L. E., eds. ThePharmacological Basis of Therapeutics, 10th ed.; McGraw-Hill: NewYork, pp 1924-2023.
18. Zhao, Y; Woo, G.; Thomas, S.; Semin, D.; Sandra, P. Rapid Method Development for Chiral Separation in Drug Discovery Using Sample Pooling and Supercritical Fluid Chromatography-Mass Spectrometry. J. Chromatogr. A 2003, 1003 (1-2), 157-166.